Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Leo E Gerweck"'
Autor:
Wende Li, Sen Li, Ivy X. Chen, Yujiao Liu, Rakesh R. Ramjiawan, Chi-Ho Leung, Leo E. Gerweck, Dai Fukumura, Jay S. Loeffler, Rakesh K. Jain, Dan G. Duda, Peigen Huang
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-12 (2021)
Abstract Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/neu + BC to prevent met
Externí odkaz:
https://doaj.org/article/72ed3803e97d40d080480ecd872ff483
Autor:
Qixian Zhang, Leo E. Gerweck, Ethan Cascio, Liqun Gu, Qingyuan Yang, Xinyue Dong, Peigen Huang, Alejandro Bertolet, Konrad Pawel Nesteruk, Wonmo Sung, Aimee L. McNamara, Jan Schuemann
Publikováno v:
Cancers; Volume 15; Issue 8; Pages: 2269
Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0c53b42deb622821d64e9f308f804a
Autor:
Leo E. Gerweck
Publikováno v:
Thermal Effects on Cells and Tissues ISBN: 9780429070365
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dee853c34ff252c6a5b6dabf8763e14
https://doi.org/10.1201/9780429070365-4
https://doi.org/10.1201/9780429070365-4
Publikováno v:
Biomedicines, Vol 3, Iss 2, Pp 182-200 (2015)
Accumulating evidence suggests that ubiquitin E3 ligases are involved in cancer development as their mutations correlate with genomic instability and genetic susceptibility to cancer. Despite significant findings of cancer-driving mutations in the BR
Externí odkaz:
https://doaj.org/article/0b41513df50a4700a4096b992161c9dc
Publikováno v:
Precision Clinical Medicine. 3:272-283
Cancer has become a leading cause of death and constitutes an enormous burden worldwide. Radiation is a principle treatment modality used alone or in combination with other forms of therapy, with 50%–70% of cancer patients receiving radiotherapy at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7295241c473069e304d3a152e7069f9e
https://doi.org/10.1093/pcmedi/pbaa038
https://doi.org/10.1093/pcmedi/pbaa038
FLASH radiation has been reported to efficiently suppress tumor growth while sparing normal tissue, however, the mechanism of the differential tissue sparing effect is still not known. Oxygen has long been known to profoundly impact radiobiological r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d248cc9ab17db046f26357f07b5f73d
http://arxiv.org/abs/2201.02278
http://arxiv.org/abs/2201.02278
Autor:
Qixian Zhang, Leo E Gerweck, Ethan Cascio, Qingyuan Yang, Peigen Huang, Andrzej Niemierko, Alejandro Bertolet, Konrad Pawel Nesteruk, Aimee McNamara, Jan Schuemann
Publikováno v:
Physics in Medicine & Biology. 68:055010
Objective. Irradiation at FLASH dose rates (>40 Gy s−1) has received great attention due to its reported normal tissue sparing effect. The FLASH effect was originally observed in electron irradiations but has since been shown to also occur with bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e73c18220a16aace302cd1310c3c18
https://doi.org/10.1088/1361-6560/acb888
https://doi.org/10.1088/1361-6560/acb888
Autor:
Chi-Ho Leung, Jay S. Loeffler, Ivy X. Chen, Rakesh K. Jain, Yujiao Liu, Sen Li, Dan G. Duda, Rakesh R. Ramjiawan, Peigen Huang, Wende Li, Dai Fukumura, Leo E. Gerweck
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-12 (2021)
Radiation Oncology (London, England)
Radiation Oncology (London, England)
Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/neu + BC to prevent metastatic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934fa9bdd31df795a07177affefe0806
https://doi.org/10.1186/s13014-021-01775-9
https://doi.org/10.1186/s13014-021-01775-9
Autor:
Chengming Li, Qixian Zhang, J Flanz, Jan Schuemann, Qingyuan Yang, Bernard Gottschalk, Leo E. Gerweck, Peigen Huang, E Cascio
Publikováno v:
Radiation Research. 194
Extremely high-dose-rate irradiation, referred to as FLASH, has been shown to be less damaging to normal tissues than the same dose administrated at conventional dose rates. These results, typically seen at dose rates exceeding 40 Gy/s (or 2,400 Gy/m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496d2c2778c4693343850237181b81b2
https://doi.org/10.1667/rade-20-00068.1
https://doi.org/10.1667/rade-20-00068.1
Autor:
Ming Fang Lin, Chia Wei Li, Chia Yuen Chen, Hao Wang, Leo E. Gerweck, Wing P. Chan, Yuan Hao Lee
Publikováno v:
Acta Radiologica. 60:61-67
Background Multiple rounds of head computed tomography (CT) scans increase the risk of radiation-induced lens opacification. Purpose To investigate the effects of CT eye shielding and topogram-based tube current modulation (TCM) on the radiation dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b1b97b7445e8f6a031fe0c2df93ef7
https://doi.org/10.1177/0284185118770894
https://doi.org/10.1177/0284185118770894