Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Leo E, Otterbein"'
Autor:
Rodrigo W. Alves de Souza, Vanessa Voltarelli, David Gallo, Sidharth Shankar, Michael S. Tift, Mark Young, Edward Gomperts, Andrew Gomperts, Leo E. Otterbein
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Doxorubicin and other anthracyclines are crucial cancer treatment drugs. However, they are associated with significant cardiotoxicity, severely affecting patient care and limiting dosage and usage. Previous studies have shown that low carb
Externí odkaz:
https://doaj.org/article/c052d993bf7c44808e7eb723bc64da75
Autor:
Jianling Bi, Emily Witt, Megan K. McGovern, Arielle B. Cafi, Lauren L. Rosenstock, Anna B. Pearson, Timothy J. Brown, Thomas B. Karasic, Lucas C. Absler, Srija Machkanti, Hannah Boyce, David Gallo, Sarah L. Becker, Keiko Ishida, Joshua Jenkins, Alison Hayward, Alexandra Scheiflinger, Kellie L. Bodeker, Ritesh Kumar, Scott K. Shaw, Salma K. Jabbour, Vitor A. Lira, Michael D. Henry, Michael S. Tift, Leo E. Otterbein, Giovanni Traverso, James D. Byrne
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract Modulation of autophagy, specifically its inhibition, stands to transform the capacity to effectively treat a broad range of cancers. However, the clinical efficacy of autophagy inhibitors has been inconsistent. To delineate clinical and epi
Externí odkaz:
https://doaj.org/article/f858b9587aa7486a8b205a415ae94226
Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors
Autor:
Jianling Bi, Emily Witt, Vanessa A. Voltarelli, Vivian R. Feig, Veena Venkatachalam, Hannah Boyce, Megan McGovern, Wade R. Gutierrez, Jeffrey D. Rytlewski, Kate R. Bowman, Ashley C. Rhodes, Austin N. Cook, Benjamin N. Muller, Matthew G. Smith, Alexis Rebecca Ramos, Heena Panchal, Rebecca D. Dodd, Michael D. Henry, Adam Mailloux, Giovanni Traverso, Leo E. Otterbein, James D. Byrne
Publikováno v:
Advanced Science, Vol 10, Iss 10, Pp n/a-n/a (2023)
Abstract Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the response
Externí odkaz:
https://doaj.org/article/8033b7f9c53848e996896b38f139de6d
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102183- (2021)
The relationship between carbon monoxide and the heart has been extensively studied in both clinical and preclinical settings. The Food and Drug Administration (FDA) is keenly focused on the ill effects of carbon monoxide on the heart when presented
Externí odkaz:
https://doaj.org/article/8c97861a33494d5f9c5114ddc0caee9a
Autor:
Ghee Rye Lee, David Gallo, Rodrigo W. Alves de Souza, Shilpa Tiwari-Heckler, Eva Csizmadia, James D. Harbison, Sidharth Shankar, Valerie Banner-Goodspeed, Michael B. Yaffe, Maria Serena Longhi, Carl J. Hauser, Leo E. Otterbein
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
Infection is a common complication of major trauma that causes significantly increased morbidity and mortality. The mechanisms, however, linking tissue injury to increased susceptibility to infection remain poorly understood. To study this relationsh
Externí odkaz:
https://doaj.org/article/e7c9bf0316e4446796b2509b0694bf31
Autor:
Rodrigo W. Alves de Souza, David Gallo, Ghee Rye Lee, Eri Katsuyama, Alexa Schaufler, Janick Weber, Eva Csizmadia, George C. Tsokos, Lauren G. Koch, Steven L. Britton, Ulrik Wisløff, Patricia C. Brum, Leo E. Otterbein
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109018- (2021)
Summary: Physical exercise has profound effects on quality of life and susceptibility to chronic disease; however, the regulation of skeletal muscle function at the molecular level after exercise remains unclear. We tested the hypothesis that the ben
Externí odkaz:
https://doaj.org/article/6b7b353c78914a5ea96007141e2a3be5
Autor:
Michael S. Tift, Rodrigo W. Alves de Souza, Janick Weber, Erica C. Heinrich, Francisco C. Villafuerte, Atul Malhotra, Leo E. Otterbein, Tatum S. Simonson
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-rep
Externí odkaz:
https://doaj.org/article/faa39b6162fa4b2c9ad35d48e6a632cf
Autor:
Shahzad Shaefi, Edward R. Marcantonio, Ariel Mueller, Valerie Banner-Goodspeed, Simon C. Robson, Kyle Spear, Leo E. Otterbein, Brian P. O’Gara, Daniel S. Talmor, Balachundhar Subramaniam
Publikováno v:
Trials, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract Background Postoperative cognitive dysfunction (POCD) is a common complication of cardiac surgery. Studies have identified potentially injurious roles for cardiopulmonary bypass (CPB) and subsequent reperfusion injury. Cognitive dysfunction
Externí odkaz:
https://doaj.org/article/775c6378fbb7473e82c5f0226794148f
Autor:
Ingred Goretti Riça, Brian A. Joughin, Martha E. Teke, Tiffany R. Emmons, Alec M. Griffith, Laura A. Cahill, Valerie M. Banner-Goodspeed, Simon C. Robson, Jonathan M. Hernandez, Brahm H. Segal, Leo E. Otterbein, Carl J. Hauser, James A. Lederer, Michael B. Yaffe
Publikováno v:
Journal of Trauma and Acute Care Surgery. 94:187-196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d961ab205c579d972756070151c9bcfa
https://doi.org/10.1097/ta.0000000000003823
https://doi.org/10.1097/ta.0000000000003823
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cellular protective mechanisms exist to ensure survival of the cells and are a fundamental feature of all cells that is necessary for adapting to changes in the environment. Indeed, evolution has ensured that each cell is equipped with multiple overl
Externí odkaz:
https://doaj.org/article/02373636929e4c97aa3e4ec7552f4396