Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Leo C James"'
Autor:
KM Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Böcking
Publikováno v:
eLife, Vol 13 (2024)
The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stabil
Externí odkaz:
https://doaj.org/article/08ba42401fe84baebde255dedc84b832
Autor:
Nadine Renner, Donna L Mallery, K M Rifat Faysal, Wang Peng, David A Jacques, Till Böcking, Leo C James
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009164 (2021)
The HIV capsid self-assembles a protective conical shell that simultaneously prevents host sensing whilst permitting the import of nucleotides to drive DNA synthesis. This is accomplished through the construction of dynamic, highly charged pores at t
Externí odkaz:
https://doaj.org/article/a8eba9633dfb4fecbe34fc3f141ac79b
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion.
Autor:
Guido Papa, Donna L Mallery, Anna Albecka, Lawrence G Welch, Jérôme Cattin-Ortolá, Jakub Luptak, David Paul, Harvey T McMahon, Ian G Goodfellow, Andrew Carter, Sean Munro, Leo C James
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009246 (2021)
Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the host cell receptor ACE2 and undergoing virus-host membrane fusion. Fusion is triggered by the protease TMPRSS2, which processes the viral Spike (S) protein t
Externí odkaz:
https://doaj.org/article/e7f61576d1094208b86f915b6e68af06
Autor:
Sarah L Caddy, Marina Vaysburd, Mark Wing, Stian Foss, Jan Terje Andersen, Kevin O'Connell, Keith Mayes, Katie Higginson, Miren Iturriza-Gómara, Ulrich Desselberger, Leo C James
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008732 (2020)
Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high levels of protective antibodies. Antibodies targeting the middle capsid protein VP6 are particularly abundant, and as VP6 is only exposed inside cells,
Externí odkaz:
https://doaj.org/article/c6b9aa3d13534f2291fb97316d6e6156
Autor:
Jingwei Zeng, Leo C James
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008657 (2020)
Externí odkaz:
https://doaj.org/article/c8d234302bbd45efb77430754b5165a9
Publikováno v:
eLife, Vol 8 (2019)
The genetic basis of most human disease cannot be explained by common variants. One solution to this ‘missing heritability problem’ may be rare missense variants, which are individually scarce but collectively abundant. However, the phenotypic im
Externí odkaz:
https://doaj.org/article/65a9c35cc176438198232cb7754fa9fb
Autor:
Donna L Mallery, Chantal L Márquez, William A McEwan, Claire F Dickson, David A Jacques, Madhanagopal Anandapadamanaban, Katsiaryna Bichel, Gregory J Towers, Adolfo Saiardi, Till Böcking, Leo C James
Publikováno v:
eLife, Vol 7 (2018)
The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP6, transforming viral stability from minutes to hours
Externí odkaz:
https://doaj.org/article/7c6859948eca463995437484988a1476
Autor:
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James
Publikováno v:
eLife, Vol 7 (2018)
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknow
Externí odkaz:
https://doaj.org/article/5202b947b0ec499ebb78db70bf28d54e
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein.
Autor:
Kseniya Khamina, Alexander Lercher, Michael Caldera, Christopher Schliehe, Bojan Vilagos, Mehmet Sahin, Lindsay Kosack, Anannya Bhattacharya, Peter Májek, Alexey Stukalov, Roberto Sacco, Leo C James, Daniel D Pinschewer, Keiryn L Bennett, Jörg Menche, Andreas Bergthaler
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006758 (2017)
RNA-dependent RNA polymerases (RdRps) play a key role in the life cycle of RNA viruses and impact their immunobiology. The arenavirus lymphocytic choriomeningitis virus (LCMV) strain Clone 13 provides a benchmark model for studying chronic infection.
Externí odkaz:
https://doaj.org/article/61f6526a55ef46658467aab0a567e0fd
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005253 (2015)
Encapsidation is a strategy almost universally employed by viruses to protect their genomes from degradation and from innate immune sensors. We show that TRIM21, which targets antibody-opsonized virions for proteasomal destruction, circumvents this p
Externí odkaz:
https://doaj.org/article/b86ace7174324237b3feeb9bbf05ff47