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Akademický článek

A versatile system to record cell-cell interactions

Autor: Rui Tang, Christopher W Murray, Ian L Linde, Nicholas J Kramer, Zhonglin Lyu, Min K Tsai, Leo C Chen, Hongchen Cai, Aaron D Gitler, Edgar Engleman, Wonjae Lee, Monte M Winslow

Publikováno v: eLife, Vol 9 (2020)

Cell-cell interactions influence all aspects of development, homeostasis, and disease. In cancer, interactions between cancer cells and stromal cells play a major role in nearly every step of carcinogenesis. Thus, the ability to record cell-cell inte

Externí odkaz: https://doaj.org/article/13a418d59ffc4122921111ddb10c3638

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Akademický článek

Deep Learning for Automated Delineation of Pediatric Cerebral Arteries on Pre-operative Brain Magnetic Resonance Imaging

Autor: Jennifer L. Quon, Leo C. Chen, Lily Kim, Gerald A. Grant, Michael S. B. Edwards, Samuel H. Cheshier, Kristen W. Yeom

Publikováno v: Frontiers in Surgery, Vol 7 (2020)

Introduction: Surgical resection of brain tumors is often limited by adjacent critical structures such as blood vessels. Current intraoperative navigations systems are limited; most are based on two-dimensional (2D) guidance systems that require manu

Externí odkaz: https://doaj.org/article/27953ec460bf41a888fbd0f737f6ddc6

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Figure S1-S17, Table S3 from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer

(Updated, with minor text changes and rearrangements.) Figure S1-S4 (related to Figure 1) provide details on the selected genes and method. Figure S5 (related to Figure 2) shows the percentiles of all sgRNAs. Figure S6-S8 (related to Figure 3) presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb999fe9b53b0a94ffbad60dec52b16e
https://doi.org/10.1158/2159-8290.22540429

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Data from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer

Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis is a multistep process, but the importance and specific roles of many of these genes during tumor initiation, growth, and progression remain unknown. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b404e969247084e511f71eff4ac10a
https://doi.org/10.1158/2159-8290.c.6549376

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Table S2 from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer

Table S2. The information of sgRNA vectors in the high content Lenti-sgTS102/Cre pool.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd3cce0b27516cffd3dcfa9479b7b40
https://doi.org/10.1158/2159-8290.22540423

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Improved Electrophile Design for Exquisite Covalent Molecule Selectivity

Autor: José L. Montaño, Brian J. Wang, Regan F. Volk, Sara E. Warrington, Virginia G. Garda, Katherine L. Hofmann, Leo C. Chen, Balyn W. Zaro

Publikováno v: ACS Chemical Biology. 17:1440-1449

Covalent inhibitors are viable therapeutics. However, off-target reactivity challenges the field. Chemists have attempted to solve this issue by varying the reactivity attributes of electrophilic warheads. Here, we report the development of an approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364ace47f942fd01162d93a41146c42c
https://doi.org/10.1021/acschembio.1c00980

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Registration of presurgical MRI and histopathology images from radical prostatectomy via RAPSODI

Autor: Richard E. Fan, Mirabela Rusu, Rewa Sood, Wei Shao, Simon John Christoph Soerensen, Geoffrey A. Sonn, Leo C Chen, Nikola C. Teslovich, Jeffrey B. Wang, Pejman Ghanouni, James D. Brooks, Christian A. Kunder

Publikováno v: Rusu, M, Shao, W, Kunder, C A, Wang, J B, Soerensen, S J C, Teslovich, N C, Sood, R R, Chen, L C, Fan, R E, Ghanouni, P, Brooks, J D & Sonn, G A 2020, ' Registration of presurgical MRI and histopathology images from radical prostatectomy via RAPSODI ', Medical Physics, vol. 47, no. 9, pp. 4177-4188 . https://doi.org/10.1002/mp.14337
Medical Physics

Purpose: Magnetic resonance imaging (MRI) has great potential to improve prostate cancer diagnosis; however, subtle differences between cancer and confounding conditions render prostate MRI interpretation challenging. The tissue collected from patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589fd02ea656e1b3f71966296670f842
https://doi.org/10.1002/mp.14337

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