Zobrazeno 1 - 10
of 5 667
pro vyhledávání: '"Leo C"'
Autor:
Shanna S. Leventhal, Thomas Bisom, Dean Clift, Deepashri Rao, Kimberly Meade-White, Carl Shaia, Justin Murray, Evan A. Mihalakakos, Troy Hinkley, Steven J. Reynolds, Sonja M. Best, Jesse H. Erasmus, Leo C. James, Heinz Feldmann, David W. Hawman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a negative-sense RNA virus spread by Hyalomma genus ticks across Europe, Asia, and Africa. CCHF disease begins as a non-specific febrile illness which may progress into a severe hemorrhagic di
Externí odkaz:
https://doaj.org/article/a6d956186c9942bda98b2bc1f3d16cfd
Autor:
Alex Kleinpeter, Donna L. Mallery, Nadine Renner, Anna Albecka, J. Ole Klarhof, Eric O. Freed, Leo C. James
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions ar
Externí odkaz:
https://doaj.org/article/146fe9a36e924c2a89d4ea1eeb9173fc
Autor:
Peiming Chen, Mimi M. Y Tse, Shamay S.M. Ng, Leo C. M. Ho, Anthony T. C. Kwok, Sam C. Y. Lam, Tai Wa Liu, Thomson W. L. Wong, Billy C. L. So, Cynthia Y. Y. Lai
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
ObjectiveTo investigate the psychometric properties of the Lift and Carry Test (LCT) time in people with stroke.DesignCross-sectional design.SettingUniversity based neurorehabilitation laboratory.ParticipantsTwenty-four people with stroke and 24 heal
Externí odkaz:
https://doaj.org/article/ed38405eaf8f4c4388cf2be23ffc7226
Autor:
Shilin Zhao, Kris Y. W. Lok, Zhen Y. Sin, Ye Peng, Heidi S. L. Fan, Nitya Nagesh, Martha S. L. Choi, Jojo Y. Y. Kwok, Edmond P. H. Choi, Xi Zhang, Hogan Kok-Fung Wai, Leo C. H. Tsang, Samuel S. M. Cheng, Matthew K. L. Wong, Jie Zhu, Chris K. P. Mok, Siew C. Ng, Francis K. L. Chan, Malik Peiris, Leo L. M. Poon, Hein M. Tun
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Newborns can acquire immunological protection to SARS-CoV-2 through vaccine-conferred antibodies in human breast milk. However, there are some concerns around lactating mothers with regards to potential short- and long-term adverse events an
Externí odkaz:
https://doaj.org/article/97c98fea7c374c10952279eef846a51e
Autor:
Qichao Wu, Xiang Cui, Leo C. Guan, Chi Zhang, Jing Liu, Neil C. Ford, Shaoqiu He, Xueming Chen, Xu Cao, Lei Zang, Yun Guan
Publikováno v:
Journal of Orthopaedic Translation, Vol 42, Iss , Pp 147-159 (2023)
Chronic pain after spine surgery (CPSS) is often characterized by intractable low back pain and/or radiating leg pain, and has been reported in 8–40% of patients that received lumbar spine surgery. We conducted a literature search of PubMed, MEDLIN
Externí odkaz:
https://doaj.org/article/5704d83fd0844018a832a16dad6762e6
Autor:
Katherine U. Gaynor, Marina Vaysburd, Maximilian A. J. Harman, Anna Albecka, Phillip Jeffrey, Paul Beswick, Guido Papa, Liuhong Chen, Donna Mallery, Brian McGuinness, Katerine Van Rietschoten, Steven Stanway, Paul Brear, Aleksei Lulla, Katarzyna Ciazynska, Veronica T. Chang, Jo Sharp, Megan Neary, Helen Box, Jo Herriott, Edyta Kijak, Lee Tatham, Eleanor G. Bentley, Parul Sharma, Adam Kirby, Ximeng Han, James P. Stewart, Andrew Owen, John A. G. Briggs, Marko Hyvönen, Michael J. Skynner, Leo C. James
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of both. Bicycles are entropica
Externí odkaz:
https://doaj.org/article/83eee9acaa674188b99a7694be9c0c15
Autor:
KM Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Böcking
Publikováno v:
eLife, Vol 13 (2024)
The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stabil
Externí odkaz:
https://doaj.org/article/08ba42401fe84baebde255dedc84b832
Autor:
George A. Alba, Iris Y. Zhou, Molly Mascia, Michael Magaletta, Jehan W. Alladina, Francesca L. Giacona, Leo C. Ginns, Peter Caravan, Bradley A. Maron, Sydney B. Montesi
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Compared to healthy volunteers, participants with post‐acute sequelae of SARS‐CoV‐2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular
Externí odkaz:
https://doaj.org/article/12422b0881fd4dc08ae772bf641eb802
Autor:
Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F. Dickson, Jonas Weidenhausen, Shannon Smyly, Ji-Chun Yang, Sarah L. Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C. James
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating targeted protein degradation during Trim-Away. Despite their importance, the ubiquitin
Externí odkaz:
https://doaj.org/article/9847497c03534f53b81f80ff92484d91
Autor:
Arinze Duke George Nwosu, Leo C Chukwu, Okechukwu Onwuasoigwe, Sylvester O Nweze, Kenneth Nwadike
Publikováno v:
Indian Journal of Pain, Vol 37, Iss 2, Pp 65-73 (2023)
Conventional analgesics have traditionally been the mainstay of pain management, but unsatisfactory pain relief and troubling side effects have led to continuing search for more efficacious and safer remedies. Adjuvant analgesics are drugs with benef
Externí odkaz:
https://doaj.org/article/4ae705f352794121974052a581d99763