Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Leo Beigelman"'
Autor:
Paul C Jordan, Cheng Liu, Pauline Raynaud, Michael K Lo, Christina F Spiropoulou, Julian A Symons, Leo Beigelman, Jerome Deval
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006889 (2018)
Paramyxoviruses represent a family of RNA viruses causing significant human diseases. These include measles virus, the most infectious virus ever reported, in addition to parainfluenza virus, and other emerging viruses. Paramyxoviruses likely share c
Externí odkaz:
https://doaj.org/article/dea86e2bd0344eeb9640ba04bd6ec5f4
Autor:
Jerome Deval, Amy Fung, Sarah K Stevens, Paul C Jordan, Tatiana Gromova, Joshua S Taylor, Jin Hong, Jia Meng, Guangyi Wang, Natalia Dyatkina, Marija Prhavc, Julian A Symons, Leo Beigelman
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154097 (2016)
ALS-8112 is the parent molecule of ALS-8176, a first-in-class nucleoside analog prodrug effective in the clinic against respiratory syncytial virus (RSV) infection. The antiviral activity of ALS-8112 is mediated by its 5'-triphosphate metabolite (ALS
Externí odkaz:
https://doaj.org/article/eb54ace55dde433abdc2bb3f2b3bb609
Autor:
Jerome Deval, Jin Hong, Guangyi Wang, Josh Taylor, Lucas K Smith, Amy Fung, Sarah K Stevens, Hong Liu, Zhinan Jin, Natalia Dyatkina, Marija Prhavc, Antitsa D Stoycheva, Vladimir Serebryany, Jyanwei Liu, David B Smith, Yuen Tam, Qingling Zhang, Martin L Moore, Rachel Fearns, Sushmita M Chanda, Lawrence M Blatt, Julian A Symons, Leo Beigelman
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004995 (2015)
Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a first-in-class nucleoside analog prodrug effective in RSV-infected adult volunteers, and curren
Externí odkaz:
https://doaj.org/article/2d5adaa211d8415eabca3c2fc3171ff6
Autor:
Sushmita Chanda, Keith Nieforth, Dymphy Huntjens, Matthew McClure, John P. DeVincenzo, Patrick F. Smith, Kashyap Patel, Leo Beigelman, Lawrence M. Blatt, Carl M. J. Kirkpatrick, Qingling Zhang, Julian Symons, John Fry
Publikováno v:
Journal of Antimicrobial Chemotherapy. 74:442-452
Background Respiratory syncytial virus (RSV) causes high morbidity, with mortality rates approaching or exceeding that of influenza in adult and infant patient populations, respectively. Lumicitabine (ALS-008176 or JNJ-64041575) is an oral nucleoside
Autor:
Zhinan Jin, Andreas Jekle, Natalia B. Dyatkina, April Kinkade, Leo Beigelman, Shuvam Chaudhuri, Vivek K. Rajwanshi, Jerome Deval, Ishani Behera, Julian A. Symons, Kathryn Tucker, Guangyi Wang, David B. Smith
Publikováno v:
Antiviral Research. 143:151-161
Recent cases of severe toxicity during clinical trials have been associated with antiviral ribonucleoside analogs (e.g. INX-08189 and balapiravir). Some have hypothesized that the active metabolites of toxic ribonucleoside analogs, the triphosphate f
Autor:
Guangyi Wang, Yuen Tam, Antitsa Dimitrova Stoycheva, Jerome Deval, Sarah K. Stevens, Leo Beigelman, Ryan P. Pemberton, Julian A. Symons, Shuvam Chaudhuri, Paul C. Jordan, Natalia B. Dyatkina
Publikováno v:
ACS Chemical Biology. 12:83-91
Human respiratory syncytial virus (RSV) is a negative-sense RNA virus and a significant cause of respiratory infection in infants and the elderly. No effective vaccines or antiviral therapies are available for the treatment of RSV. ALS-8176 is a firs
Autor:
C. Cheng Kao, Leo Beigelman, Zhinan Jin, Natalia B. Dyatkina, Jerome Deval, Ken Shaw, Hua Tan, Ishani Behera, Julian Symons, Kathryn Tucker, Vivek K. Rajwanshi, Guangyi Wang, Xiaoyan Lin
Publikováno v:
Antimicrobial Agents and Chemotherapy
Norovirus (NoV) is a positive-sense single-stranded RNA virus that causes acute gastroenteritis and is responsible for 200,000 deaths per year worldwide. No effective vaccine or treatment is available. Recent studies have shown that the nucleoside an
Autor:
David Smith, Joshua S. Taylor, Jyanwei Liu, Guangyi Wang, Yuen Tam, Marija Prhavc, Julian Symons, Qingling Zhang, Vladimir Serebryany, Natalia B. Dyatkina, Leo Beigelman, Sarah K. Stevens, Jin Hong, Lawrence M. Blatt, Jerome Deval, Sushmita Chanda, Zhinan Jin, Amy Fung
Publikováno v:
Journal of Medicinal Chemistry. 58:1862-1878
Respiratory syncytial virus (RSV) is a leading pathogen of childhood and is associated with significant morbidity and mortality. To date, ribavirin is the only approved small molecule drug, which has limited use. The only other RSV drug is palivizuma
Publikováno v:
Current Opinion in Virology
Highlights • New therapies for infections caused by positive-strand RNA viruses are needed. • Novel nucleoside and nucleotide analogs that inhibit HCV have been developed. • Some of these molecules also inhibit other positive-strand RNA viruses
Autor:
H. Masur, M. Grimley, S. Kottilil, John Fry, J. Hickok, Leo Beigelman, M. Gluck, A. R. Bellamy, S. Edupuganti, C. Richards, M. J. Bonten, Matthew W. McClure, Q. Zhang, P. Winokur, S. Kabbani, M. Bolkenbaas, S. S. Huang, Lisa Harrison, H.-Y. Chiang, P. Sears, C. Scaglioni-Weinlich, Sushmita Chanda, E. J. Anderson, H. Hill, Rob Lambkin-Williams, W. Drews, A. Kohli, John P. DeVincenzo, S. Okubo, A. S. Ross, A. Nelson, D. Jacobsohn, J. Moody, Hosnieh Fathi, E. Perencevich, M. J. Mulligan, J. Duchin, B. Braun, M. Berrey, M. Schweizer, W. C. Gruber, N. Rouphael, S. Flanagan, D. Ince, Lawrence M. Blatt, C. Westland, J. Perlin, C. Webber, S. Klish, K. Wendorf, Z. Sims, T. Brundage, Julian Symons, D. Bernstein, K. Nieforth, E. Meissner, M. O'gorman, L. A. Herwaldt, S. Weissman, M. Zahn, D. E. Grobbee, G. Maron, S. K. Gohil, M. Michaels, Patrick F. Smith, E. Septimus, S. L. Kaplan, D. L. Noah, P. Verma, J. G. Mchutchison, L. Lai, R. Rupp, D. J. Diekema, S. M. Huijts, J.-A. Young, D. A. Scott, M. Dickey, S. D. Patterson, M. Kay, C. Baliga, P. W. Spearman, J. T. Stapleton, G. Chittick, M. Ward, C. S. Team, H. Mommeja-Marin, J. Hafner
Publikováno v:
Open Forum Infectious Diseases. 1:S66-S69