Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Leo Barnes"'
Autor:
Judith A. Varner, Mark Ginsberg, David Cheresh, Sarah L. Blair, Andrew Lowy, Thalia Papayannopoulou, Chloe Feral, Leo Barnes, Lesley G. Ellies, Philippe Foubert, Michael C. Schmid, Christie J. Avraamides, Barbara Garmy-Susini
Supplementary Figures 1-10 from Integrin α4β1 Signaling Is Required for Lymphangiogenesis and Tumor Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8a0b5bc769810531c17b4fa07f4a74
https://doi.org/10.1158/0008-5472.22387031
https://doi.org/10.1158/0008-5472.22387031
Autor:
Shuichan Xu, Ning Jiang, Rama K. Narla, Jennifer Riggs, Tao Shi, Sophie X. Peng, Yuhong Ning, Heather Raymon, Dan Zhu, Gordafaried Deyanat-Yazdi, David Mikolon, John F. Boylan, Leo Barnes, Tam Tran
Publikováno v:
Molecular Cancer Therapeutics. 17:1727-1738
Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered using a phenotypic screen for compounds that preferentially induced apoptosis in triple-negative brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273b7f2034f8d7318e39b7bd2a91e6af
https://doi.org/10.1158/1535-7163.mct-17-1084
https://doi.org/10.1158/1535-7163.mct-17-1084
Autor:
Paul J. Pockros, Sara M. Weis, Richard Aspinall, David A. Cheresh, Leo Barnes, Kimberly Lutu-Fuga, David J. Bylund
Publikováno v:
Liver International. 31:1222-1230
Background and aims: Acute liver failure (ALF) is frequently complicated by cerebral oedema, systemic inflammation and multiorgan dysfunction. Vascular endothelial growth factor (VEGF) may stimulate liver regeneration but it can also be pro-inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a24c67c18695ce405d90f089a260fe1
https://doi.org/10.1111/j.1478-3231.2011.02554.x
https://doi.org/10.1111/j.1478-3231.2011.02554.x
Autor:
Jay S. Desgrosellier, Miller Huang, Sanford J. Shattil, David Tarin, Leo Barnes, Steven K. M. Lau, Nicolas Prévost, David J. Shields, David A. Cheresh
Publikováno v:
Nature medicine
Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin alpha(v)beta(3) is associated with progression of a variety of human tumors. Here we reveal a previously undescribed adhesion-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7896fbb9d9360fa630638d449f8ed2
https://doi.org/10.1038/nm.2009
https://doi.org/10.1038/nm.2009
Autor:
Sara M. Weis, Kimberly Lutu-Fuga, Leo Barnes, Bharat Majeti, Eric A. Murphy, David A. Cheresh, Milan Makale, Wolfgang Wrasidlo
Publikováno v:
Proceedings of the National Academy of Sciences. 105:9343-9348
Integrin alphanubeta3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an alphanubeta3-targeted nanoparticle (NP) encapsulating the cytotoxic drug doxorubicin (Dox) for targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0e6b3c14da11c9c3fff82cadd42260
https://doi.org/10.1073/pnas.0803728105
https://doi.org/10.1073/pnas.0803728105
Autor:
Patrick Hagner, Jolanta Kosek, Michael Pourdehnad, Jian Kang, Hon-Wah Man, Peter H. Schafer, Courtney G. Havens, Rama K. Narla, Anita Gandhi, Emily Rychak, Anjan Thakurta, Anke Klippel, Celia Fontanillo, Antonia Lopez-Girona, Leo Barnes, Hsiling Chiu, Gang Lu, Matthew Trotter, Michelle Waldman, Chad C. Bjorklund, Heather Raymon, Michael D. Amantangelo, Rajesh Chopra, Thomas O. Daniel, Gody Khambatta, Ti Cai, Suzana Couto, Maria Wang, Mike Breider
Publikováno v:
Blood. 126(6)
Cereblon (CRBN), a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex, is the target of the immunomodulatory drugs lenalidomide and pomalidomide. Recently, it was demonstrated that binding of these drugs to CRBN promotes the ubiquiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59febe5218f33d889fbd52a12fe1517c
https://pubmed.ncbi.nlm.nih.gov/26251224
https://pubmed.ncbi.nlm.nih.gov/26251224
Autor:
Jianhua Cui, Sara M. Weis, David A. Cheresh, Kimberly Lutu-Fuga, Leo Barnes, Malcolm R. Wood, Jeffrey N. Lindquist
Publikováno v:
Blood. 109:1962-1970
In the developing myocardium, vascular endothelial growth factor (VEGF)–dependent neovascularization occurs by division of existing vessels, a process that persists for several weeks following birth. During this remodeling phase, mRNA expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf929a198ca60fa1013ecf840a1f2ea
https://doi.org/10.1182/blood-2005-10-038893
https://doi.org/10.1182/blood-2005-10-038893
Publikováno v:
The Journal of Cell Biology
VEGF is unique among angiogenic growth factors because it disrupts endothelial barrier function. Therefore, we considered whether this property of VEGF might contribute to tumor cell extravasation and metastasis. To test this, mice lacking the Src fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba67ef83f02334ec0629bf1006205c0
https://doi.org/10.1083/jcb.200408130
https://doi.org/10.1083/jcb.200408130
Autor:
Alice Yam, Ryan Stafford, Maureen Fitch Bruhns, Millicent Embry, Stuart Bussell, Arturo Molina, Trevor J. Hallam, Mark Lupher, Toni Kline, Adam Galan, Shannon Matheny, Michael Brown, Venita DeAlmeida, John F. Boylan, Eric Schwartz, Cristina Abrahams, Jason Kahana, Alexander Steiner, Abigail Yu, Aaron K. Sato, James Zawada, Heather Stephenson, Leo Barnes, Henry Heinsohn, Nicki Vasquez, Rama K. Narla, Heidi Hoffmann, Xiaofan Li
Publikováno v:
Blood. 128:464-464
CD74 is a type II transmembrane glycoprotein involved in the formation and transport of MHC class II protein. High expression of CD74 has been confirmed in follicular lymphoma, diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008142baec3e3dfb7c79e2e10baf02fb
https://doi.org/10.1182/blood.v128.22.464.464
https://doi.org/10.1182/blood.v128.22.464.464
Autor:
Bharat Majeti, Lisette M. Acevedo, David A. Cheresh, Rajesh Mukthavaram, Leo Barnes, Eric A. Murphy
Publikováno v:
Molecular cancer therapeutics. 10(6)
Although nanoparticle-based drug delivery formulations can improve the effectiveness and safety of certain anticancer drugs, many drugs, due to their chemical composition, are unsuitable for nanoparticle loading. Here, we describe a targeted nanogel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478fc70edc245dbc8dcfe82c937a210b
https://pubmed.ncbi.nlm.nih.gov/21518727
https://pubmed.ncbi.nlm.nih.gov/21518727