Association of the X-Chromosomal GenesTIMP1andIL9Rwith Rheumatoid Arthritis

Autor: Elisabeth Petit-Teixeira, Alejandro Balsa, Grit Wolfram, Timothy R D J Radstake, Thomas Bardin, Peter Ahnert, Ulrike Buchegger-Podbielski, Pilar Barrera, Rene Westhovens, Helena Alves, Bernard Prum, Paola Migliorini, Sandra Ruehle, Sophie Garnier, Dora Pascual-Salcedo, Inga Melchers, Markus Scholz, Frank Emmrich, Jana Burkhardt, Christian Oeser, Holger Kirsten, Piet L. C. M. van Riel, Leo B A van de Putte, Jan Dequeker, François Cornelis, Stefano Bombardieri, Vitor H. Teixeira

Publikováno v: Journal of Rheumatology
Journal of Rheumatology, 2009, 36 (10), pp.2149--2157. ⟨10.3899/jrheum.090059⟩
Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2009, 36 (10), pp.2149--2157. ⟨10.3899/jrheum.090059⟩
The Journal of Rheumatology, 36, 10, pp. 2149-57
The Journal of Rheumatology, 36, 2149-57

Objective.Rheumatoid arthritis (RA) is an inflammatory joint disease with features of an autoimmune disease with female predominance. Candidate genes located on the X-chromosome were selected for a family trio-based association study.Methods.A total

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038f57b4676212ffbf7549fd9522c85b
https://doi.org/10.3899/jrheum.090059

Citrulline is an Essential Constituent of Antigenic Determinants Recognized by Rheumatoid Arthritis-specific Autoantibodies. 1998

Autor: Gerard A, Schellekens, Ben A W, de Jong, Frank H J, van den Hoogen, Leo B A, van de Putte, Walther J, van Venrooij

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 195(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ffb43699e998e51114b9e4c26dee76d3
https://pubmed.ncbi.nlm.nih.gov/26092811

The C677T mutation in the methylenetetrahydrofolate reductase gene: A genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients

Autor: Cees J. Haagsma, Annelies E. van Ede, Roland Laan, Belinda A. J. Giesendorf, Theo de Boo, Henk J. Blom, Leo B A van de Putte, Tom W J Huizinga

Publikováno v: Arthritis & Rheumatism. 44:2525-2530

Objective To study the possible relationship between the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and the toxicity and efficacy of treatment with methotrexate (MTX) in patients with rheumatoid arthritis (RA). Methods Gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ac3df3f5c61e68f8eadb035bc83c6f
https://doi.org/10.1002/1529-0131(200111)44:11<2525::aid-art432>3.0.co

Basic biology and clinical application of specific cyclooxygenase-2 inhibitors

Autor: Leslie J. Crofford, Lee S. Simon, Peter Brooks, Steven B. Abramson, Leo B A van de Putte, Peter E. Lipsky

Publikováno v: Arthritis & Rheumatism. 43:4-13

In summary, COX-2 is a highly regulated gene product that catalyzes the local production of PGs in pathologic and physiologic situations (Figure 1). It is clear that COX-2 is the isoform responsible for production of the PGs that mediate inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45e4dbe04253cfccdd116983eb4ba9ec
https://doi.org/10.1002/1529-0131(200001)43:1<4::aid-anr2>3.0.co

Effects of antirheumatic agents on cytokines

Autor: Pilar Barrera, Boerbooms Am, Jos W. M. van der Meer, Leo B A van de Putte

Publikováno v: Seminars in Arthritis and Rheumatism, 25, pp. 234-253
Seminars in Arthritis and Rheumatism, 25, 234-253

A review of the literature concerning the effects of traditional antirheumaticdrugs on cytokines and the cytokine and anticytokine approaches already used in the therapy of rheumatoid arthritis (RA) is presented. Many antirheumatic drugs are capable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08885917a2e3458f796f74c1f49b12d8
https://doi.org/10.1016/s0049-0172(96)80035-7