Výsledky vyhledávání - "Leo A. J. M. Sliedregt"

Synthesis of Polyaryl Rigid-Core Carbosilane Dendrimers for Supported Organic Synthesis

Autor: Peter J. C. Hausoul, B. J. Van Steen, Leo A. J. M. Sliedregt, G. van Koten, M. Wander, R.J.M. Klein Gebbink

Publikováno v: Organometallics. 28:4406-4415

Carbosilane dendrimers can be used as soluble supports for organic synthesis, since their structure allows separation of excess reagents from the supported products, eventually yielding products of high purity and in high yield, as in solid-phase org

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a22283ee65449816d3bffe9b37ef055
https://doi.org/10.1021/om900265v

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Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation

Autor: B. J. Van Steen, Marinus B. Groen, Rob F. Schmitz, Edith Gelens, Leo A. J. M. Sliedregt, Rob Leurs, F. J. J. De Kanter, Chris G. Kruse, Romano V. A. Orru

Publikováno v: Gelens, E, De Kanter, F J J, Schmitz, R F, Sliedregt, L A, Van Steen, B J, Kruse, C G, Leurs, R, Groen, M B & Orru, R V A 2006, ' Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation ', Molecular Diversity, vol. 10, no. 1, pp. 17-22 . https://doi.org/10.1007/s11030-006-8695-3
Molecular Diversity, 10(1), 17-22. Springer Netherlands

Optimization of Radziszewski's four-component reaction employing a microwave-assisted protocol, led to a small library of 48 imidazoles with a success rate of 65% (conversion > 45%). All three diversity points of the four-component reaction were vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f66f6b6debfb36ee72f9b4c191100c
https://doi.org/10.1007/s11030-006-8695-3

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An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves

Autor: Edith Gelens, Bart J. van Steen, Luc Smeets, Rob Leurs, Chris G. Kruse, Romano V. A. Orru, Leo A. J. M. Sliedregt

Publikováno v: Gelens, E, Smeets, L, Sliedregt, L A, van Steen, B J, Kruse, C G, Leurs, R & Orru, R V A 2005, ' An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves ', Tetrahedron Letters, vol. 46, no. 21, pp. 3751-3754 . https://doi.org/10.1016/j.tetlet.2005.03.146
Tetrahedron Letters, 46(21), 3751-3754. Elsevier Limited

An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c8705cb7f7b5d737e1e12d5171b151
https://doi.org/10.1016/j.tetlet.2005.03.146

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Determination of the Upper Size Limit for Uptake and Processing of Ligands by the Asialoglycoprotein Receptor on Hepatocytesin Vitro and in Vivo

Autor: Erik A.L. Biessen, Sabine M.W. van Rossenberg, Erwin Kieviet, Leo A. J. M. Sliedregt, Theo J.C. Van Berkel, Patrick C.N. Rensen, Steven H. van Leeuwen, Michiel Ferns

Publikováno v: Journal of Biological Chemistry. 276:37577-37584

The asialoglycoprotein receptor (ASGPr) on hepatocytes plays a role in the clearance of desialylated proteins from the serum. Although its sugar preference (N-acetylgalactosamine (GalNAc) >> galactose) and the effects of ligand valency (tetraantennar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22753ecf56e18132c6f541e6babd1a7
https://doi.org/10.1074/jbc.m101786200

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Design and synthesis of a multivalent homing device for targeting to murine CD22

Autor: Sabine M.W. van Rossenberg, P. Anton van der Merwe, Christina Piperi, Gijs A. van der Marel, Theo J.C. Van Berkel, A. Rob P. M. Valentijn, Johan Kuiper, Leo A. J. M. Sliedregt, Reshma Autar, Erik A.L. Biessen, Jacques H. van Boom

Publikováno v: Bioorganic & Medicinal Chemistry. 9:85-97

CD22 is a cell-surface glycoprotein uniquely located on mature B-cells and B-cell derived tumour cells. Current evidence suggests that binding of endogenous ligands to CD22 leads to modulation of B-cell activation by antigen. Incidentally, however, B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accc09fbac93cf881f13f2dadd26d50d
https://doi.org/10.1016/s0968-0896(00)00224-8

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Design and Synthesis of Novel Amphiphilic Dendritic Galactosides for Selective Targeting of Liposomes to the Hepatic Asialoglycoprotein Receptor

Autor: P.J. van Santbrink, G. A. Van Der Marel, Martin K. Bijsterbosch, Erik T. Rump, T. J. C. Van Berkel, Patrick C.N. Rensen, A. R. P. M. Valentijn, J. H. Van Boom, Leo A. J. M. Sliedregt, E.A.L. Biessen

Publikováno v: Journal of Medicinal Chemistry. 42:609-618

A series of glycolipids have been prepared which contain a cluster galactoside moiety with high affinity for the hepatic asialoglycoprotein receptor and a bile acid ester moiety which mediates stable incorporation into liposomes. Loading of liposomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6c163da16ef24320754d141a73e16d
https://doi.org/10.1021/jm981078h

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[Untitled]

Autor: Leo A. J. M. Sliedregt, Martin K. Bijsterbosch, Theo J.C. Van Berkel, Erik A.L. Biessen, Remco L. A. de Vrueh, Erik T. Rump

Publikováno v: Pharmaceutical Research. 16:1179-1185

Purpose. 9-(2-Phosphonylmethoxyethyl)adenine (PMEA), a potent inhibitor of Hepatitis B virus replication, is in vivo hardly taken up by parenchymal liver cells (the site of infection). Our aim is to examine whether lactosylated reconstituted HDL (Lac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3f76c0b0dd06e04107d587b524b08d9
https://doi.org/10.1023/a:1018933126885

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Solid-phase synthesis of lysine-based cluster galactosides with high affinity for the asialoglycoprotein Receptor

Autor: Gijgs A. van der Marel, Leo A. J. M. Sliedregt, A. Rob P. M. Valentijn, Erik A.L. Biessen, Theo J.C. Van Berkel, Jacques H. van Boom

Publikováno v: Tetrahedron. 53:759-770

Structurally well defined di- and tri-antennary lysine-based galactose- and N-acetylgalactosamine-containing ligands for the hepatic asialoglycoprotein receptor (ASGP-R) could be assembled on a solid support, using a combined Fmoc/Alloc protecting gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13516a31a340811c155d7dd7da359684
https://doi.org/10.1016/s0040-4020(96)01018-6

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Potential usefulness of 4-nitrophenylthio- β-D-glycosides in the chemoselective synthesis of oligosaccharides

Autor: Leo A. J. M. Sliedregt, J. H. Van Boom, G. A. Van Der Marel

Publikováno v: Proceedings / Indian Academy of Sciences. 106:1213-1224

Condensation of 4-nitrophenylthioD-glycosyl acceptors with ethylthioD-glycosyl donors in the presence of thiophilic promoters IDCP and NIS/TfOH, according to the “latent-active” principle proposed by Royet al, did not proceed in all cases as expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::308106366d54330880920c99700c51d8
https://doi.org/10.1007/bf02841928

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Trimethylsilyl triflate mediated chemoselective condensation of arylsulfenyl glycosides

Autor: Leo A. J. M. Sliedregt, J. H. Van Boom, G. A. Van Der Marel

Publikováno v: Tetrahedron Letters. 35:4015-4018

Condensation of a fully benzoylated phenylsulfenyl glycoside with either benzylated or benzoylated phenylthio glycosyl acceptors under the agency of trimethylsilyl triflate proceeds with a good degree of chemoselectivity in the presence of the scaven

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https://doi.org/10.1016/s0040-4039(00)76728-1

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