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Akademický článek

Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting

Publikováno v: JCI Insight, Vol 8, Iss 6 (2023)

Glioblastoma is the most malignant primary brain tumor, the prognosis of which remains dismal even with aggressive surgical, medical, and radiation therapies. Glioblastoma stem cells (GSCs) promote therapeutic resistance and cellular heterogeneity du

Externí odkaz: https://doaj.org/article/ec0fd42d418349639d81160bf89146e0

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Akademický článek

Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis

Autor: Santiago Delgado-Tirado, MD, Lucia Gonzalez-Buendia, MD, Miranda An, BA, Dhanesh Amarnani, MS, Daniela Isaacs-Bernal, BSc, Hannah Whitmore, PhD, Said Arevalo-Alquichire, PhD, David Leyton-Cifuentes, BME, Jose M. Ruiz-Moreno, MD, PhD, Joseph F. Arboleda-Velasquez, MD, PhD, Leo A. Kim, MD, PhD

Publikováno v: Ophthalmology Science, Vol 2, Iss 3, Pp 100163- (2022)

Purpose: To test the efficacy of runt-related transcription factor 1 (RUNX1) inhibition with topical nanoemulsion containing Ro5-3335 (eNano-Ro5) in experimental ocular neovascularization. Design: Preclinical experimental study. Participants: In vitr

Externí odkaz: https://doaj.org/article/1d0498c427cb4c969e1ab719fee26a5c

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Akademický článek

Dimethyl Fumarate Blocks Tumor Necrosis Factor-Alpha-Driven Inflammation and Metabolic Rewiring in the Retinal Pigment Epithelium

Autor: Daisy Y. Shu, Scott I. Frank, Tessa C. Fitch, Margarete M. Karg, Erik R. Butcher, Emmanuella Nnuji-John, Leo A. Kim, Magali Saint-Geniez

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

The retinal pigment epithelium (RPE) acts as a metabolic gatekeeper between photoreceptors and the choroidal vasculature to maintain retinal function. RPE dysfunction is a key feature of age-related macular degeneration (AMD), the leading cause of bl

Externí odkaz: https://doaj.org/article/3648d0b4c0e048b698aee8e295c6130e

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Akademický článek

Nonperfusion Area and Other Vascular Metrics by Wider Field Swept-Source OCT Angiography as Biomarkers of Diabetic Retinopathy Severity

Autor: Itika Garg, MD, Chibuike Uwakwe, Rongrong Le, MD, PhD, Edward S. Lu, BA, Ying Cui, MD, Karen M. Wai, MD, Raviv Katz, MS, Ying Zhu, MD, Jade Y. Moon, BA, Chloe Y. Li, MD, Inês Laíns, MD, PhD, Dean Eliott, MD, Tobias Elze, PhD, Leo A. Kim, MD, PhD, David M. Wu, MD, PhD, Joan W. Miller, MD, Deeba Husain, MD, Demetrios G. Vavvas, MD, PhD, John B. Miller, MD

Publikováno v: Ophthalmology Science, Vol 2, Iss 2, Pp 100144- (2022)

Purpose: To study the wider field (WF) swept-source OCT angiography (SS-OCTA) metrics, especially the nonperfusion area (NPA), in the diagnosing and staging of diabetic retinopathy (DR). Design: Cross-sectional observational study (November 2018 to S

Externí odkaz: https://doaj.org/article/836c78b855d243e284dc5a91269030d3

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Akademický článek

ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance

Autor: Li Jiang, Yajing Hao, Changwei Shao, Qiulian Wu, Briana C. Prager, Ryan C. Gimple, Gabriele Sulli, Leo J.Y. Kim, Guoxin Zhang, Zhixin Qiu, Zhe Zhu, Xiang-Dong Fu, Jeremy N. Rich

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)

Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor, containing GBM stem cells (GSCs) that contribute to therapeutic resistance and relapse. Exposing potential GSC vulnerabilities may provide therapeutic strategies against

Externí odkaz: https://doaj.org/article/9e343997925d42dba86e8ff866779674

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Akademický článek

Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition

Autor: Pei Qin Ng, Magali Saint-Geniez, Leo A. Kim, Daisy Y. Shu

Publikováno v: Metabolites, Vol 13, Iss 2, p 213 (2023)

Epithelial-mesenchymal transition (EMT) is a dedifferentiation program in which polarized, differentiated epithelial cells lose their cell-cell adhesions and transform into matrix-producing mesenchymal cells. EMT of retinal pigment epithelial (RPE) c

Externí odkaz: https://doaj.org/article/94a8d54f68b74f5b8c62b9496afaed19

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Akademický článek

Inter-device reliability of swept source and spectral domain optical coherence tomography and retinal layer differences in schizophrenia

Autor: Swetha Gandu, Deepthi Bannai, Iniya Adhan, Megan Kasetty, Raviv Katz, Rebecca Zang, Olivia Lutz, Leo A. Kim, Matcheri Keshavan, John B. Miller, Paulo Lizano

Publikováno v: Biomarkers in Neuropsychiatry, Vol 5, Iss , Pp 100036- (2021)

Introduction: Optical coherence tomography (OCT) is used to study retinal structure in schizophrenia. Changes in retinal structure, especially the retinal nerve fiber layer (RNFL) has been correlated with psychotic disorders. Measurement variability

Externí odkaz: https://doaj.org/article/1102448a38794241aaf249441db0507f

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Association Between Contrast Sensitivity and Central Subfield Thickness in Center-Involving Diabetic Macular Edema

Autor: Grace Baldwin, Filippos Vingopoulos, Rebecca Zeng, Hannah Wescott, Augustine Bannerman, Thomas Koch, Kira Wang, Itika Garg, Raviv Katz, Leo A. Kim, John B. Miller

Publikováno v: Journal of VitreoRetinal Diseases. 7:232-238

Purpose: To evaluate the association between contrast sensitivity (CS) and central subfield thickness (CST) in diabetic macular edema (DME). Methods: This prospectively recruited, cross-sectional study included eyes with DME evaluated from November 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0efb7154ce67ff630d93c39be9875748
https://doi.org/10.1177/24741264231165611

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