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Akademický článek

Microstructural development from 9 to 14 years: Evidence from the ABCD Study

Autor: Clare E. Palmer, Diliana Pecheva, John R. Iversen, Donald J. Hagler, Jr, Leo Sugrue, Pierre Nedelec, Chun Chieh Fan, Wesley K. Thompson, Terry L. Jernigan, Anders M. Dale

Publikováno v: Developmental Cognitive Neuroscience, Vol 53, Iss , Pp 101044- (2022)

During late childhood behavioral changes, such as increased risk-taking and emotional reactivity, have been associated with the maturation of cortico-cortico and cortico-subcortical circuits. Understanding microstructural changes in both white matter

Externí odkaz: https://doaj.org/article/f913e7f198b148fe8340c627e417aa09

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Akademický článek

Multi-Disease Segmentation of Gliomas and White Matter Hyperintensities in the BraTS Data Using a 3D Convolutional Neural Network

Autor: Jeffrey D. Rudie, David A. Weiss, Rachit Saluja, Andreas M. Rauschecker, Jiancong Wang, Leo Sugrue, Spyridon Bakas, John B. Colby

Publikováno v: Frontiers in Computational Neuroscience, Vol 13 (2019)

An important challenge in segmenting real-world biomedical imaging data is the presence of multiple disease processes within individual subjects. Most adults above age 60 exhibit a variable degree of small vessel ischemic disease, as well as chronic

Externí odkaz: https://doaj.org/article/651c0143c4fe4aeaad458c0373bcc6a1

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Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 43, iss 2

Hexanucleotide repeat expansion (HRE) within C9orf72 is the most common genetic cause of frontotemporal dementia (FTD). Thalamic atrophy occurs in both sporadic and familial FTD but is thought to distinctly affect HRE carriers. Separately, emerging e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26db290663368430e8978af72589564d
https://escholarship.org/uc/item/7jr289cm

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Polygenic architecture of a novel MRI endophenotype: the 'hemochromatosis brain'

Autor: Robert Loughnan, Jonathan Ahern, Mary Boyle, Terry L. Jernigan, Donald J. Hagler, John R. Iversen, Oleksandr Frei, Diana M. Smith, Ole Andreassen, Leo Sugrue, Wesley K. Thompson, Anders Dale, Andrew J. Schork, Chun Chieh Fan

Iron is an important element required for the body to function properly; however, hemochromatosis, an excess of iron in healthy tissue, can lead to cell damage. C282Y is a genetic variant prevalent in European populations, which is known to increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f196d5ab18c886cd6ac25a082c035c9
https://doi.org/10.1101/2022.10.22.22281386

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Association of Genetic Variant Linked to Hemochromatosis With Brain Magnetic Resonance Imaging Measures of Iron and Movement Disorders

Autor: Robert Loughnan, Jonathan Ahern, Cherisse Tompkins, Clare E. Palmer, John Iversen, Wesley K. Thompson, Ole Andreassen, Terry Jernigan, Leo Sugrue, Anders Dale, Mary E. T. Boyle, Chun Chieh Fan

Publikováno v: JAMA neurology, vol 79, iss 9

ImportanceHereditary hemochromatosis (HH) is an autosomal recessive genetic disorder that leads to iron overload. Conflicting results from previous research has led some to believe the brain is spared the toxic effects of iron in HH.ObjectiveTo test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ba482097d374f429b397b057fac904
https://escholarship.org/uc/item/9gt7484s

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