Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

Autor: Yulia Kargapolova, Rizwan Rehimi, Hülya Kayserili, Joanna Brühl, Konstantinos Sofiadis, Anne Zirkel, Spiros Palikyras, Athanasia Mizi, Yun Li, Gökhan Yigit, Alexander Hoischen, Stefan Frank, Nicole Russ, Jonathan Trautwein, Bregje van Bon, Christian Gilissen, Magdalena Laugsch, Eduardo Gade Gusmao, Natasa Josipovic, Janine Altmüller, Peter Nürnberg, Gernot Längst, Frank J. Kaiser, Erwan Watrin, Han Brunner, Alvaro Rada-Iglesias, Leo Kurian, Bernd Wollnik, Karim Bouazoune, Argyris Papantonis

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Members of the CHD chromatin remodeler family are implicated in human pathologies, however CHD6 remained poorly studied. Here, the authors show that CHD6 binds to and regulates autophagy and stress response genes across cell types. They identify a cl

Externí odkaz: https://doaj.org/article/3a21a85edc97413aa5f192b307a93267

circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner

Autor: Natasa Josipovic, Karoline K. Ebbesen, Anne Zirkel, Adi Danieli-Mackay, Christoph Dieterich, Leo Kurian, Thomas B. Hansen, Argyris Papantonis

Publikováno v: Josipovic, N, Ebbesen, K K, Zirkel, A, Danieli-Mackay, A, Dieterich, C, Kurian, L, Hansen, T B & Papantonis, A 2022, ' circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner ', RNA (New York, N.Y.), vol. 28, no. 11, pp. 1481-1495 . https://doi.org/10.1261/rna.079195.122

Circular RNAs are endogenous long-lived and abundant non-coding species. Despite their prevalence, only few circRNAs have been dissected mechanistically to date. Here, we catalogued nascent RNA-enriched circRNAs from primary human cells and functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab553f15e13cc5a0819cea5271ed38db
https://doi.org/10.1261/rna.079195.122

Supplementary Data from Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma

Autor: Chandrasekhar Kanduri, Tanmoy Mondal, John Inge Johnsen, Matthias Fischer, Per Kogner, Maite Huarte, Leo Kurian, Ivan Raimondi, Santhilal Subhash, Daniel Jachimowicz, Silke Reischl, Subazini Thankaswamy Kosalai, Prasanna Kumar Juvvuna, Mirco Di Marco, Somsundar Veppil Muralidharan, Sanhita Mitra

Supplementary Text, Supplementary Table Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008277634027dcc784f8bc3001f50e37
https://doi.org/10.1158/0008-5472.22425708.v1

Data from Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma

Autor: Chandrasekhar Kanduri, Tanmoy Mondal, John Inge Johnsen, Matthias Fischer, Per Kogner, Maite Huarte, Leo Kurian, Ivan Raimondi, Santhilal Subhash, Daniel Jachimowicz, Silke Reischl, Subazini Thankaswamy Kosalai, Prasanna Kumar Juvvuna, Mirco Di Marco, Somsundar Veppil Muralidharan, Sanhita Mitra

Neuroblastoma has a low mutation rate for the p53 gene. Alternative ways of p53 inactivation have been proposed in neuroblastoma, such as abnormal cytoplasmic accumulation of wild-type p53. However, mechanisms leading to p53 inactivation via cytoplas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23078e939f7b0d29d05e56d567d1d7b8
https://doi.org/10.1158/0008-5472.c.6512115

The Human Induced Pluripotent Stem Cell Test as an Alternative Method for Embryotoxicity Testing

Autor: Saskia Galanjuk, Etta Zühr, Arif Dönmez, Deniz Bartsch, Leo Kurian, Julia Tigges, Ellen Fritsche

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 3295

The evaluation of substances for their potency to induce embryotoxicity is controlled by safety regulations. Test guidelines for reproductive and developmental toxicity rely mainly on animal studies, which make up the majority of animal usage in regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b44d823aee5618fd17907d01d014e11
https://pubmed.ncbi.nlm.nih.gov/35328717