Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Leo, Goodstadt"'
Autor:
Mona Hosseini, Leo Goodstadt, Jim R Hughes, Monika S Kowalczyk, Marco de Gobbi, Georg W Otto, Richard R Copley, Richard Mott, Douglas R Higgs, Jonathan Flint
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003570 (2013)
Variation at regulatory elements, identified through hypersensitivity to digestion by DNase I, is believed to contribute to variation in complex traits, but the extent and consequences of this variation are poorly characterized. Analysis of terminall
Externí odkaz:
https://doaj.org/article/15b7bbf556e64a6e8f69b4f366fa1d44
Autor:
Peter L Oliver, Leo Goodstadt, Joshua J Bayes, Zoë Birtle, Kevin C Roach, Nitin Phadnis, Scott A Beatson, Gerton Lunter, Harmit S Malik, Chris P Ponting
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000753 (2009)
The onset of prezygotic and postzygotic barriers to gene flow between populations is a hallmark of speciation. One of the earliest postzygotic isolating barriers to arise between incipient species is the sterility of the heterogametic sex in interspe
Externí odkaz:
https://doaj.org/article/d0a4fc2093fa4318a431d787b4e10899
Autor:
Deanna M Church, Leo Goodstadt, Ladeana W Hillier, Michael C Zody, Steve Goldstein, Xinwe She, Carol J Bult, Richa Agarwala, Joshua L Cherry, Michael DiCuccio, Wratko Hlavina, Yuri Kapustin, Peter Meric, Donna Maglott, Zoë Birtle, Ana C Marques, Tina Graves, Shiguo Zhou, Brian Teague, Konstantinos Potamousis, Christopher Churas, Michael Place, Jill Herschleb, Ron Runnheim, Daniel Forrest, James Amos-Landgraf, David C Schwartz, Ze Cheng, Kerstin Lindblad-Toh, Evan E Eichler, Chris P Ponting, Mouse Genome Sequencing Consortium
Publikováno v:
PLoS Biology, Vol 7, Iss 5, p e1000112 (2009)
The mouse (Mus musculus) is the premier animal model for understanding human disease and development. Here we show that a comprehensive understanding of mouse biology is only possible with the availability of a finished, high-quality genome assembly.
Externí odkaz:
https://doaj.org/article/a202294c2cc6477980c4641703f4b0a7
Autor:
Leo Goodstadt, Chris P Ponting
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 9, p e133 (2006)
Accurate predictions of orthology and paralogy relationships are necessary to infer human molecular function from experiments in model organisms. Previous genome-scale approaches to predicting these relationships have been limited by their use of pro
Externí odkaz:
https://doaj.org/article/befeeabf2bbe4ad6bd2c4f3cea93238f
Autor:
Jérôme Nicod, Joseph Wood, Jean-Marie Launay, Benjamin K Yee, Arimantas Lionikas, Connie R. Bezzina, Amarjit Bhomra, Jacques Callebert, Robert W. Davies, Martin Fray, Tertius Hough, Cormac Cosgrove, Barbara Nell, Leo Goodstadt, Elisabeth M. Lodder, Richard Mott, Hayley Phelps, Jonathan Flint, Paul Klenerman, Vikte Lionikaite, Paul Franken, Steve D. M. Brown, Paul Potter, Carl Hassett, Yigal M. Pinto, Sara Wells, Alison Walling, Richard M. Aspden, Nasrin Bopp, Russell Joynson, David J. Adams, Jennifer S. Gregory, Rebecca E. McIntyre, Nick P. Talbot, Tom Weaver, Na Cai, David A. Blizard, Mark Harrison, Polinka Hernandez-Pliego, Carol Ann Remme, Peter A. Robbins, Clare Rowe
Publikováno v:
Nature genetics, 48(8), 912-918. Nature Publishing Group
Nature genetics
Nature Genetics
Nature Genetics, vol. 48, no. 8, pp. 912-918
Nature genetics
Nature Genetics
Nature Genetics, vol. 48, no. 8, pp. 912-918
Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c43f733d0e02d16156ca7a0f9e4be1
https://doi.org/10.1038/ng.3595
https://doi.org/10.1038/ng.3595
Autor:
Kerstin Howe, Thomas M. Keane, Paul Flicek, David Thybert, Bronwen Aken, David Martín-Gálvez, Golbahar Yazdanifar, Christine Feig, Cristina Sisu, Duncan T. Odom, Son Pham, Stefanie Nachtweide, Laura Clarke, Ian Streeter, Carla Cummins, Varshith Chakrapani, Lilue Jingtao, Cock van Oosterhout, Ian T. Fiddes, Alvis Brazma, David J. Adams, William Chow, Frédéric Veyrunes, Maša Roller, Mikhail Kolmogorov, Christina M. Laukaitis, Ambre Aurore Josselin, Matthew Howell, Fergal J. Martin, Klara Stefflova, Benedict Paten, Mario Stanke, Matthieu Muffato, Mark Gerstein, Leo Goodstadt, Fengtang Yang, Michael A. Quail, Anthony G. Doran, Václav Janoušek, Ben J. Ward, Sarah Aldridge, Amonida Zadissa, Fabio C. P. Navarro, Robert C. Karn, Matthew Dunn, Wasiu Akanni
Publikováno v:
Genome Research
Genome Research, Cold Spring Harbor Laboratory Press, 2018, 28 (4), pp.448-459. ⟨10.1101/gr.234096.117⟩
Genome Research, 2018, 28 (4), pp.448-459. ⟨10.1101/gr.234096.117⟩
Genome Research, Cold Spring Harbor Laboratory Press, 2018, 28 (4), pp.448-459. ⟨10.1101/gr.234096.117⟩
Genome Research, 2018, 28 (4), pp.448-459. ⟨10.1101/gr.234096.117⟩
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609fd04d943fa94511f96a605cf6355f
https://www.repository.cam.ac.uk/handle/1810/279898
https://www.repository.cam.ac.uk/handle/1810/279898
Autor:
Dent Earl, Monica Abrudan, Benedict Paten, Adam Frankish, Lesley Shirley, Cristina Sisu, Ian T. Fiddes, Mark Gerstein, James G. R. Gilbert, Mark G. Thomas, Anne Czechanski, Duncan T. Odom, William Chow, Stephan C. Collins, Clayton E. Mathews, Mark Diekhans, Ruth Bennett, Jane E. Loveland, David J. Adams, Jingtao Lilue, Beiyuan Fu, Dirk-Dominic Dolle, Fengtang Yang, Laura G. Reinholdt, Glen Threadgold, Anne C. Ferguson-Smith, Jonathan Wood, Kim Wong, Leo Goodstadt, Paul R. Muir, Thomas M. Keane, Phan Sk, Jonathan Flint, Naomi R Park, Richard Mott, Joel Armstrong, Thybert D, Jen Harrow, Petr Danecek, Marcela K. Sjoberg-Herrera, Sarah Pelan, Anthony G. Doran, Kerstin Howe, Charles A. Steward, Mario Stanke, Binnaz Yalcin, Joanna Collins, Lelliott C, Matthew Dunn, Fabio C. P. Navarro, Michael A. Quail, Paul Flicek, James Torrance, Richard Durbin, Köenig S, Lars Romoth, Mikhail Kolmogorov
The most commonly employed mammalian model organism is the laboratory mouse. A wide variety of genetically diverse inbred mouse strains, representing distinct physiological states, disease susceptibilities, and biological mechanisms have been develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71500bb485bfaa2d484c7df8a7e4cb83
https://doi.org/10.1101/235838
https://doi.org/10.1101/235838
Autor:
Leo Goodstadt, Mark Gerstein, Mark G. Thomas, Jingtao Lilue, Glen Threadgold, Fengtang Yang, Sarah Pelan, Jane E. Loveland, Kim Wong, Fabio C. P. Navarro, Jennifer Harrow, Ruth Bennett, Richard Durbin, Dent Earl, Monica Abrudan, Mario Stanke, David J. Adams, Adam Frankish, Son Pham, Anne Czechanski, Charles A. Steward, Jonathan Flint, Beiyuan Fu, Ian T. Fiddes, William Chow, Duncan T. Odom, Marcela K. Sjoberg-Herrera, Naomi Park, Paul Flicek, Anne C. Ferguson-Smith, James G. R. Gilbert, Lelliott C, Mikhail Kolmogorov, Mark Diekhans, Laura G. Reinholdt, Stefanie Nachtweide, Cristina Sisu, Thomas M. Keane, James Torrance, Richard Mott, Benedict Paten, Petr Danecek, Dirk-Dominik Dolle, Paul R. Muir, Ximena Ibarra-Soria, Stephan C. Collins, Binnaz Yalcin, Darren W. Logan, Lars Romoth, Matthew Dunn, Lesley Shirley, Kerstin Howe, David Thybert, Michael A. Quail, Clayton E. Mathews, Jonathan Wood, Anthony G. Doran, Joanna Collins, Joel Armstrong
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, 2018, 50 (11), pp.1574-1583. ⟨10.1038/s41588-018-0223-8⟩
Nature Genetics, 2018, 50 (11), pp.1574-1583. ⟨10.1038/s41588-018-0223-8⟩
Nature genetics
Nature Genetics, Nature Publishing Group, 2018, 50 (11), pp.1574-1583. ⟨10.1038/s41588-018-0223-8⟩
Nature Genetics, 2018, 50 (11), pp.1574-1583. ⟨10.1038/s41588-018-0223-8⟩
Nature genetics
We report full-length draft de novo genome assemblies for 16 widely used inbred mouse strains and find extensive strain-specific haplotype variation. We identify and characterize 2,567 regions on the current mouse reference genome exhibiting the grea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc230ec19054ff114163ced9d381919
http://bura.brunel.ac.uk/handle/2438/16930
http://bura.brunel.ac.uk/handle/2438/16930
Autor:
David, Thybert, Maša, Roller, Fábio C P, Navarro, Ian, Fiddes, Ian, Streeter, Christine, Feig, David, Martin-Galvez, Mikhail, Kolmogorov, Václav, Janoušek, Wasiu, Akanni, Bronwen, Aken, Sarah, Aldridge, Varshith, Chakrapani, William, Chow, Laura, Clarke, Carla, Cummins, Anthony, Doran, Matthew, Dunn, Leo, Goodstadt, Kerstin, Howe, Matthew, Howell, Ambre-Aurore, Josselin, Robert C, Karn, Christina M, Laukaitis, Lilue, Jingtao, Fergal, Martin, Matthieu, Muffato, Stefanie, Nachtweide, Michael A, Quail, Cristina, Sisu, Mario, Stanke, Klara, Stefflova, Cock, Van Oosterhout, Frederic, Veyrunes, Ben, Ward, Fengtang, Yang, Golbahar, Yazdanifar, Amonida, Zadissa, David J, Adams, Alvis, Brazma, Mark, Gerstein, Benedict, Paten, Son, Pham, Thomas M, Keane, Duncan T, Odom, Paul, Flicek
Publikováno v:
Genome research. 28(4)
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::622afc0c0d9bfd569cb3fcfbc1ed723a
https://pubmed.ncbi.nlm.nih.gov/29853203
https://pubmed.ncbi.nlm.nih.gov/29853203
Autor:
Anthony G. Doran, Václav Janoušek, David Martín-Gálvez, Robert C. Karn, Fengtang Yang, Fergal J. Martin, Klara Stefflova, Mario Stanke, Duncan T. Odom, William Chow, Ian T. Fiddes, Paul Flicek, Mark Gerstein, Golbahar Yazdanifar, Christine Feig, Ian Streeter, Ben J. Ward, Wasiu Akanni, Varshith Chakrapani, Cock van Oosterhout, David Thybert, Sarah Aldridge, Amonida Zadissa, Laura Clarke, David J. Adams, Christina M. Laukaitis, Alvis Brazma, Maša Roller, Thomas M. Keane, Michael A. Quail, Lilue Jingtao, Cristina Sisu, Carla Cummins, Bronwen Aken, Matthieu Muffato, Leo Goodstadt, Frédéric Veyrunes, Matthew Howell, Fabio C. P. Navarro, Son Pham, Mikhail Kolmogorov, Matthew Dunn, Ambre Aurore Josselin, Benedict Paten, Kerstin Howe
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2986e9e3db033fccd34237ec60a2b55
https://doi.org/10.1101/158659
https://doi.org/10.1101/158659