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A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

Autor: Maher, Steven P, Bakowski, Malina A, Vantaux, Amelie, Flannery, Erika L, Andolina, Chiara, Gupta, Mohit, Antonova-Koch, Yevgeniya, Argomaniz, Magdalena, Monica, Cabrera-Mora, Brice, Campo, Chao, Alexander T, Chatterjee, Arnab K, Cheng, Wayne T, Cooper, Caitlin A, Karissa, Cottier, Galinski, Mary R, Harupa-Chung, Anke, Ji, Hana, Joseph, Sean B, Lenz, Todd, Lonardi, Stefano, Matheson, Jessica, Mikolajczak, Sebastian A, Padin-Irizarry, Vivian, Pan, Kastin, Peneau, Julie, Prudhomme, Jacques, Roesch, Camille, Ruberto, Anthony A, Sabnis, Saniya S, Saney, Celia L, Sattabongkot, Jetsumon, Sereshki, Saleh, Suriyakan, Sangrawee, Timothy, Moeller, Ubalee, Ratawan, Wang, Yinsheng, Wasisakun, Praphan, Yin, Jiekai, McNamara, Case W, Joyner, Chester J, Nosten, Francois, Witkowski, Benoit, Le Roch, Karine G, Kyle, Dennis E

Publikováno v: bioRxiv, vol 4, iss 02-10

Radical cure of Plasmodium vivax malaria must include elimination of quiescent "hypnozoite" forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug targets, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::441b5fbf9fbed4515faf0e35703b5388
https://escholarship.org/uc/item/5xg122bt

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Insights into the evolution, virulence and speciation of Babesia MO1 and Babesia divergens through multiomics analyses.

Autor: Singh P; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Vydyam P; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Fang T; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Estrada K; Unidad Universitaria de Secuenciacion Masiva y Bioinformatica, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico., Gonzalez LM; Laboratorio de Referencia e Investigación en Parasitología, National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain., Grande R; Unidad Universitaria de Secuenciacion Masiva y Bioinformatica, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico., Kumar M; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Chakravarty S; Department of Computer Science and Engineering, University of California, Riverside, CA, USA., Berry V; LIRMM - Université de Montpellier, CNRS, Montpellier, France., Ranwez V; AGAP Institut, Université de Montpellier, CIRAD, INRAE, Institut Agro, Montpellier, France., Carcy B; MIVEGEC, Univ. Montpellier, CNRS, IRD, CHU, Montpellier, France., Depoix D; Unité Molécules de Communication et Adaptation des Microorganismes (MCAM, UMR7245), Muséum National d'Histoire Naturelle, CNRS, Paris, France., Sánchez S; Laboratorio de Referencia e Investigación en Infecciones Bacterianas Transmitidas por Agua y Alimentos, National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain., Cornillot E; Institut de Biologie Computationnelle (IBC), and Institut de Recherche en Cancérologie de Montpellier (IRCM - INSERM U1194), Institut régional du Cancer Montpellier (ICM) & Université de Montpellier, Montpellier, France., Abel S; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA., Ciampossin L; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA., Lenz T; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA., Harb O; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA., Sanchez-Flores A; Unidad Universitaria de Secuenciacion Masiva y Bioinformatica, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico., Montero E; Laboratorio de Referencia e Investigación en Parasitología, National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain., Le Roch KG; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA., Lonardi S; Department of Computer Science and Engineering, University of California, Riverside, CA, USA., Mamoun CB; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.

Publikováno v: Emerging microbes & infections [Emerg Microbes Infect] 2024 Dec; Vol. 13 (1), pp. 2386136. Date of Electronic Publication: 2024 Sep 01.

Multiomics analysis reveals B. MO1 as a distinct Babesia species and provides insights into its evolution and virulence.

Autor: Singh P, Vydyam P, Fang T, Estrada K, Gonzalez LM, Grande R, Kumar M, Chakravarty S, Berry V, Ranwez V, Carcy B, Depoix D, Sánchez S, Cornillot E, Abel S, Ciampossin L, Lenz T, Harb O, Sanchez-Flores A, Montero E, Le Roch KG, Lonardi S, Ben Mamoun C

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 18. Date of Electronic Publication: 2024 Jan 18.