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pro vyhledávání: '"Leny Dias"'
Autor:
Daniel Blackler, Martin R. Pollak, Leny Dias, Herbert Lannon, David J. Friedman, Seth L. Alper, Shrijal S Shah
Publikováno v:
Kidney Int
The apolipoprotein L1 (APOL1) risk variants G1 and G2 are associated with high rates of kidney disease in African Americans in genetic studies. However, our understanding of APOL1 biology has lagged far behind. Here we report that engineering G1 and
Autor:
David J. Friedman, Martin R. Pollak, Shrijal S Shah, Seth L. Alper, Herbert Lannon, Leny Dias, Jia-Yue Zhang
Publikováno v:
Journal of the American Society of Nephrology. 30:2355-2368
Background Genetic Variants in Apolipoprotein L1 (APOL1) are associated with large increases in CKD rates among African Americans. Experiments in cell and mouse models suggest that these risk-related polymorphisms are toxic gain-of-function variants
Autor:
Shrijal S, Shah, Herbert, Lannon, Leny, Dias, Jia-Yue, Zhang, Seth L, Alper, Martin R, Pollak, David J, Friedman
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Genetic Variants in Apolipoprotein L1 (APOL1) are associated with large increases in CKD rates among African Americans. Experiments in cell and mouse models suggest that these risk-related polymorphisms are toxic gain-of-function variants