Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold

Autor: Nela Bibire, Florentina Lupașcu, Sylvain Routier, Frédéric Buron, Sandra Constantin, Alexandru Sava, Alin Viorel Focșa, Lenuţa Profire, Alina Panainte

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7079, p 7079 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 13

Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing indomethacin derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs, 8a–p) have been developed as a saf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1543a93fb6927e9886f070b2c3fd81
https://www.mdpi.com/1422-0067/22/13/7079

New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies

Autor: Frédéric Buron, Sylvain Routier, Lenuţa Profire, Alina Panainte, Nela Bibire, Alexandru Sava

Publikováno v: Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111678-(2021)

In this study we present design and synthesis of nineteen new nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold (NO-IND-TZDs) (6a-s), as a new safer and efficient multi-targets strategy for inflammatory diseases. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9b0bdd5cdd4d081e540728c2a04888
https://doi.org/10.1016/j.biopha.2021.111678

List of Contributors

Autor: Mihaela Cristina Baican, Matej Bračič, Catalina Natalia Cheaburu-Yilmaz, Aurica P. Chiriac, Sandra Madalina Constantin, Andreia Corciova, Alina Diaconu, Hatice Yesim Karasulu, Neli Koseva, Anca Margineanu, Violeta Mitova, Bogdanel Silvestru Munteanu, Iordana Neamtu, Manuela Tatiana Nistor, Loredana Elena Nita, Daniela Pamfil, Zdenka Peršin, Lenuţa Profire, Tijana Ristić, Alina Gabriela Rusu, Olivera Šauperl, Elena Stoleru, Simona Strnad, Zornica Todorova, Ivelina Tsacheva, Cornelia Vasile, Ali Yorgancioglu, Onur Yilmaz, Lidija Fras Zemljič

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11e3b70eb2d59e4b59c40d653d1140e6
https://doi.org/10.1016/b978-0-12-813932-5.00023-6

Biological Evaluation of Azetidine-2-One Derivatives of Ferulic Acid as Promising Anti-Inflammatory Agents

Autor: Andreea Teodora Iacob, Lenuţa Profire, Catalina Elena Lupusoru, Oana Maria Dragostin, Maria Drăgan, Carmen Lăcrămioara Zamfir, Catalina Stan, Mihaela Boanca

Publikováno v: Processes, Vol 8, Iss 1401, p 1401 (2020)
Processes
Volume 8
Issue 11

The purpose of this study was to evaluate the in vivo biological potential of new azetidine-2-one derivatives of ferulic acid (6a&ndash
f). First, the in vivo acute toxicity of azetidine-2-one derivatives of ferulic acid on Swiss white mice was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdd8e7625e21814c8c7406686006a5a
https://doi.org/10.3390/pr8111401

EVALUATION OF ANTIOXIDANT ACTIVITY OF SOME IMINES DERIVATIVES OF L-ARGININE

Autor: Andreea-Teodora, Iacob, Maria, Drăgan, Sandra, Constantin, Florentina, Lupaşcu, Luminiţa, Confederat, F, Buron, S, Routier, Lenuţa, Profire

Publikováno v: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 120(2)

L-Arginine is an a-amino acid which plays important roles in different diseases or processes, such as Alzheimer disease, inflammatory process, healing and tissue regeneration and it also could be useful as an anti-atherosclerotic agent.Considering th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1789646e44c0d17926a1396342445a8a
https://pubmed.ncbi.nlm.nih.gov/27483732