Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Lentivirus/*genetics"'
Autor:
Alexia Boizot, Sylvain Moser, Virginie Zimmer, Nicole Déglon, Mélanie Sipion, Sara Regio, Maria Rey, Morgane Humbel, Ludiwine Aeby, Mergim Ramosaj
Publikováno v:
Gene Therapy
Gene therapy, vol. 28, no. 1-2, pp. 75-88
Gene therapy, vol. 28, no. 1-2, pp. 75-88
Gene transfer is a widely developed technique for studying and treating genetic diseases. However, the development of therapeutic strategies is challenging, due to the cellular and functional complexity of the central nervous system (CNS), its large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0caf98d1e7ad605f836975aa1ada83fb
https://doi.org/10.1038/s41434-020-0172-6
https://doi.org/10.1038/s41434-020-0172-6
Autor:
Magnani, A., Semeraro, M., Adam, F., Booth, C., Dupré, L., Morris, E. C., Gabrion, A., Roudaut, C., Borgel, D., Toubert, A., Clave, E., Abdo, C., Gorochov, G., Petermann, R., Guiot, M., Miyara, M., Moshous, D., Magrin, E., Denis, A., Suarez, F., Lagresle, C., Roche, A. M., Everett, J., Trinquand, A., Guisset, M., Bayford, J. Xu, Hacein-Bey-Abina, S., Kauskot, A., Elfeky, R., Rivat, C., Abbas, S., Gaspar, H. B., Macintyre, E., Picard, C., Bushman, F. D., Galy, A., Fischer, A., Six, E., Thrasher, A. J., Cavazzana, M.
Publikováno v:
NATURE MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Universidad de las Islas Baleares
Nature Medicine
Nature Medicine, 2022, 28 (1), pp.71-80. ⟨10.1038/s41591-021-01641-x⟩
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Universidad de las Islas Baleares
Nature Medicine
Nature Medicine, 2022, 28 (1), pp.71-80. ⟨10.1038/s41591-021-01641-x⟩
Patients with Wiskott–Aldrich syndrome (WAS) lacking a human leukocyte antigen-matched donor may benefit from gene therapy through the provision of gene-corrected, autologous hematopoietic stem/progenitor cells. Here, we present comprehensive, long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3f98b89d4b68a773ab2a2e9643726a
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21058
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21058
Autor:
Sara Zanivan, Eduardo Nagore, Katharina Roeck, Victor Traves, Patricia A.J. Muller, Angeliki Malliri, Emily J. Kay, Luisa Motta, Andrew P. Porter, Amaya Viros, Simon J Furney, Caroline Gaudy-Marqueste, Shilpa Gurung, Charles H. Earnshaw, Jean Krutmann, Sarah Craig, Timothy Budden
Publikováno v:
Budden, T, Gaudy-Marqueste, C, Porter, A, Kay, E, Gurung, S, Earnshaw, C H, Roeck, K, Craig, S, Traves, V, Krutmann, J, Muller, P, Motta, L, Zanivan, S, Malliri, A, Furney, S J, Nagore, E & Virós, A 2021, ' Ultraviolet light-induced collagen degradation inhibits melanoma invasion ', Nature Communications, vol. 12, no. 1, 2742 . https://doi.org/10.1038/s41467-021-22953-z
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Ultraviolet radiation (UVR) increases the incidence of cutaneous melanoma1–4. The ageing, sun-exposed dermis accumulates UVR damage5, and older patients develop more melanomas at UVR-exposed sites4,6,7. As fibroblasts are functionally heterogeneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071297cecab6a5af770da7b7117ab089
https://eprints.gla.ac.uk/241457/1/241457.pdf
https://eprints.gla.ac.uk/241457/1/241457.pdf
Autor:
Deschamps, Marina, Decot, Véronique, Giverne, Camille, Pinturaud, Marine, Vaissié, Alix, Parquet, Nathalie, Olivero, Sylvain, Mamez, Anne-Claire, Bay, Jacques-Olivier, Yakoub-Agha, Ibrahim, Ferrand, Christophe
Publikováno v:
Bulletin du cancer, Vol. 107, No 1S (2020) pp. S85-S93
The extraordinary and unexpected success of cellular immunotherapy using genetically engineered T-cells to express a chimeric antigen receptor (CAR) targeting CD19, in the treatment of refractory or relapsing B-hematological malignancies, has provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1400::fc3930c51bdf3f23532771b56c7ef998
https://archive-ouverte.unige.ch/unige:154738
https://archive-ouverte.unige.ch/unige:154738
Autor:
Alexandre Matet, Knut Stieger, Corinne Kostic, Samia Martin, Vazrik Amirjanians, Alexis-Pierre Bemelmans, Serge G. Rosolen, Alexandre Moulin, Francine Behar-Cohen, Birgit Lorenz, Yvan Arsenijevic, Fulvio Mavilio
Publikováno v:
Transl Res
Transl Res, 2017, 188, pp.40-57 e4. ⟨10.1016/j.trsl.2017.06.012⟩
Translational research, vol. 188, pp. 40-57.e4
Transl Res, 2017, 188, pp.40-57 e4. ⟨10.1016/j.trsl.2017.06.012⟩
Translational research, vol. 188, pp. 40-57.e4
International audience; Several approaches have been developed for gene therapy in RPE65-related Leber congenital amaurosis. To date, strategies that have reached the clinical stages rely on adeno-associated viral vectors and two of them documented l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d57b50d90d4de0b26f4e86782c9074
https://hdl.handle.net/11380/1199456
https://hdl.handle.net/11380/1199456
Autor:
Pamela S. Ohashi, Karl S. Lang, C Ehlting, Philipp A. Lang, Aleksandra A. Pandyra, Carsten J. Kirschning, Albert Zimmermann, Haifeng C. Xu, Tak W. Mak, Dieter Häussinger, Dirk Brenner, Jun Huang, John Hiscott, Vitaly I. Pozdeev, Ira R. Kim, Hartmut Hengel, David R. McIlwain, Sathish Kumar Maney, Renan Aguilar-Valenzuela, Johannes G. Bode
Publikováno v:
Maney, S K, Xu, H C, Huang, J, Pandyra, A A, Ehlting, C, Aguilar-Valenzuela, R, Pozdeev, V I, McIlwain, D R, Zimmermann, A, Bode, J G, Hengel, H, Kirschning, C J, Kim, I R, Hiscott, J, Brenner, D, Häussinger, D, Ohashi, P S, Mak, T W, Lang, K S & Lang, P A 2016, ' RAIDD Mediates TLR3 and IRF7 Driven Type i Interferon Production ', Cellular Physiology and Biochemistry, vol. 39, no. 4, pp. 1271-1280 . https://doi.org/10.1159/000447832
Cellular Physiology and Biochemistry, Vol 39, Iss 4, Pp 1271-1280 (2016)
Cellular Physiology and Biochemistry, Vol 39, Iss 4, Pp 1271-1280 (2016)
Background/Aims: Viral infections represent a global health problem with the need for new viral therapies and better understanding of the immune response during infection. The most immediate and potent anti-viral defense mechanism is the production o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0327c40686133a6f9e17f51926c4434
https://doi.org/10.1159/000447832
https://doi.org/10.1159/000447832
Autor:
Parinda A. Mehta, Julián Sevilla, Maria Roser Pujol, José A. Casado, Anne Galy, Sabine Charrier, María L. Lamana, Rebeca Sanchez-Dominguez, Cristina Díaz de Heredia, Jordi Surrallés, Rosa Yañez, Guillermo Guenechea, José C. Segovia, Susana Navarro, Juan A. Bueren, Paula Río
Publikováno v:
Blood
Blood, 2017, 130 (13), pp.1535-1542. ⟨10.1182/blood-2017-03-774174⟩
Blood, American Society of Hematology, 2017, 130 (13), pp.1535-1542. ⟨10.1182/blood-2017-03-774174⟩
BLOOD
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Blood, 2017, 130 (13), pp.1535-1542. ⟨10.1182/blood-2017-03-774174⟩
Blood, American Society of Hematology, 2017, 130 (13), pp.1535-1542. ⟨10.1182/blood-2017-03-774174⟩
BLOOD
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
International audience; Previous Fanconi anemia (FA) gene therapy studies have failed to demonstrate engraftment of gene-corrected hematopoietic stem and progenitor cells (HSPCs) from FA patients, either after autologous transplantation or infusion i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf37e2a2bf00b94877944883f51001b
https://hal.science/hal-02881013
https://hal.science/hal-02881013
Autor:
Laszlo Vutskits, Patrick Salmon, Alexandre Dayer, Gael Potter, Inge Roman, Michael Boitard, Eloisa Zgraggen, Michiko Kanemitsu, Jozsef Zoltan Kiss
Publikováno v:
Cerebral Cortex, Vol. 22, No 1 (2012) pp. 144-57
Cerebral Cortex
Cerebral Cortex
The cingulate and retrosplenial regions are major components of the dorsomedial (dm) limbic cortex and have been implicated in a range of cognitive functions such as emotion, attention, and spatial memory. While the structure and connectivity of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b976b299c5c5057dc7daad13a8d929a
http://doc.rero.ch/record/302203/files/bhr097.pdf
http://doc.rero.ch/record/302203/files/bhr097.pdf
Autor:
Cleo Goyvaerts, Geert Raes, Y. De Vlaeminck, D. Escors, Karine Breckpot, Marleen Keyaerts, Stefan Lienenklaus
Targeting transgene expression specifically to antigen-presenting cells (APCs) has been put forward as a promising strategy to direct the immune system towards immunity. We developed the nanobody-display technology to restrict the tropism of lentivir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22104bd6b0670509017ffe2ba8532fd3
https://hdl.handle.net/20.500.14017/587016b2-7b18-456e-bc03-713f7b59bcb3
https://hdl.handle.net/20.500.14017/587016b2-7b18-456e-bc03-713f7b59bcb3
Autor:
Maria Prat, Piercarla Schinco, Thierry VandenDriessche, Marinee Chuah, Valder R. Arruda, Warut Tulalamba, Valentina Bruscaggin, Antonia Follenzi, Elvira S. Cannizzo, Guido Valente, Ester Borroni, Simone Merlin
Publikováno v:
Molecular therapy, 25 (8
Hemophilia A (HA) is an X-linked bleeding disease caused by factor VIII (FVIII) deficiency. We previously demonstrated that FVIII is produced specifically in liver sinusoid endothelial cells (LSECs) and to some degree in myeloid cells, and thus, in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb3f71e0df8b8a80c36239de7acbe4e
https://europepmc.org/articles/PMC5542771/
https://europepmc.org/articles/PMC5542771/