Výsledky vyhledávání - "Lentini Laura"

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Akademický článek

Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells

Autor: Barra Viviana, Schillaci Tiziana, Lentini Laura, Costa Giuseppe, Di Leonardo Aldo

Publikováno v: Cell Division, Vol 7, Iss 1, p 2 (2012)

Abstract Background Aneuploidy has been acknowledged as a major source of genomic instability in cancer, and it is often considered the result of chromosome segregation errors including those caused by defects in genes controlling the mitotic spindle

Externí odkaz: https://doaj.org/article/5d380bd94d024b3b88f4097ccc4f709b

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Akademický článek

CENPA overexpression promotes genome instability in pRb-depleted human cells

Autor: Lentini Laura, Schillaci Tiziana, Amato Angela, Di Leonardo Aldo

Publikováno v: Molecular Cancer, Vol 8, Iss 1, p 119 (2009)

Abstract Background Aneuploidy is a hallmark of most human cancers that arises as a consequence of chromosomal instability and it is frequently associated with centrosome amplification. Functional inactivation of the Retinoblastoma protein (pRb) has

Externí odkaz: https://doaj.org/article/6768fe3f707440309b1f968bba10125d

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Akademický článek

RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation

Autor: Iovino Flora, Schillaci Tiziana, Lentini Laura, Amato Angela, Di Leonardo Aldo

Publikováno v: BMC Cell Biology, Vol 10, Iss 1, p 79 (2009)

Abstract Background Changes in chromosome number or structure as well as supernumerary centrosomes and multipolar mitoses are commonly observed in human tumors. Thus, centrosome amplification and mitotic checkpoint dysfunctions are believed possible

Externí odkaz: https://doaj.org/article/3074ec328d9b40f7aa4af95d9723df56

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Akademický článek

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

Autor: Schillaci Tiziana, Amato Angela, Lentini Laura, Di Leonardo Aldo

Publikováno v: BMC Cancer, Vol 7, Iss 1, p 212 (2007)

Abstract Background Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberrations, gains or losses o

Externí odkaz: https://doaj.org/article/b014b13a0bd9434bb4707de074018a8d

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Akademický článek

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts

Autor: Amato Angela, Lentini Laura, Iovino Flora, Di Leonardo Aldo

Publikováno v: Molecular Cancer, Vol 5, Iss 1, p 38 (2006)

Abstract Background Incorrect segregation of whole chromosomes or parts of chromosome leads to aneuploidy commonly observed in cancer. The correct centrosome duplication, assuring assembly of a bipolar mitotic spindle, is essential for chromosome seg

Externí odkaz: https://doaj.org/article/a64e28142aae4af79382c1e245be0b4b

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