A New Class of Tunable Acid-Sensitive Linkers for Native Drug Release Based on the Trityl Protecting Group.

Autor: Timmers M; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands.; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CG, The Netherlands., Weterings J; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands., van Geijn M; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands., Bell R; Symeres, Nijmegen 6546 BB, The Netherlands., Lenting PE; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, U.K., Rijcken CJF; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands., Vermonden T; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CG, The Netherlands., Hennink WE; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CG, The Netherlands., Liskamp RMJ; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands.; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, U.K.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, The Netherlands.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2022 Sep 21; Vol. 33 (9), pp. 1707-1715. Date of Electronic Publication: 2022 Aug 18.