Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Lens fiber cell differentiation"'
Autor:
Stephanie L. Padula, Elaine P. Sidler, Frank J. Lovicu, Courtney J. Manz, Michael L. Robinson, Brad D. Wagner
Publikováno v:
Dev Biol
Fibroblast growth factor receptor (FGFR) signaling patterns multiple tissues in both vertebrates and invertebrates, largely through the activation of intracellular kinases. Recent studies have demonstrated that the phosphatase, PTEN negatively regula
Autor:
Chun Liang, Salil A. Lachke, Michael L. Robinson, Thanh Hoang, Blake R. Chaffee, Deepti Anand, Lin Liu, Stephanie L. Padula
Publikováno v:
Hum Genet
FGFR signaling is critical to development and disease pathogenesis, initiating phosphorylation-driven signaling cascades, notably the RAS-RAF-MEK-ERK and PI3 K-AKT cascades. PTEN antagonizes FGFR signaling by reducing AKT and ERK activation. Mouse le
Publikováno v:
Biochemical and Biophysical Research Communications. 512:927-933
Mammals possess four Sall transcription factors that play various roles in organogenesis. Previously, we found that Sall1 is expressed in microglia in the central nervous system, and it plays pivotal roles in microglia maturation. In the eye, Sall1 w
Publikováno v:
Experimental eye research. 209
A hallmark feature of lens development and differentiation is the complete elimination of organelles from the center of the eye lens. A long unanswered question in lens biology is what are the mechanisms that control the elimination of organelles dur
A Functional Map of Genomic HIF1α-DNA Complexes in The Eye Lens Revealed Through Multiomics Analysis
Autor:
Marc Kantorow, Daniel Chauss, Jason Kantorow, Joshua Disatham, Behdad Afzali, Lisa A. Brennan
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-20 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-20 (2021)
Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5937a6873de8395a2efdd5f1e143bfa1
https://doi.org/10.21203/rs.3.rs-247248/v1
https://doi.org/10.21203/rs.3.rs-247248/v1
Autor:
Melissa Lopez-Jones, Robert A. Coleman, Robert H. Singer, Peng Guo, Adrien Senecal, Saima Limi, Ales Cvekl, Christina Polumbo, Arthur I. Skoultchi
Publikováno v:
Journal of Biological Chemistry. 293:13176-13190
Genes are transcribed in irregular pulses of activity termed transcriptional bursts. Cellular differentiation requires coordinated gene expression; however, it is unknown whether the burst fraction (i.e. the number of active phases of transcription)
Publikováno v:
Human Genetics. 137:315-328
The Forkhead box E3 (FOXE3) gene encodes a transcription factor with a forkhead/winged helix domain that is critical for development of the lens and anterior segment of the eye. Monoallelic and biallelic deleterious sequence variants in FOXE3 cause a
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1867:165998
The molecular and cellular basis for cataract development in mice lacking dystrophin, a scaffolding protein that links the cytoskeleton to the extracellular matrix, is poorly understood. In this study, we characterized lenses derived from the dystrop
Publikováno v:
Differentiation. 92:133-147
Integrins are heterodimeric cell surface molecules that mediate cell-extracellular matrix (ECM) adhesion, ECM assembly, and regulation of both ECM and growth factor induced signaling. However, the developmental context of these diverse functions is n
Autor:
Kevin L. Schey, Kurt O. Gilliland, M. Joseph Costello, Marc Kantorow, Sönke Johnsen, Lisa A. Brennan, Ashik Mohamed
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0241631 (2020)
PLoS ONE, Vol 15, Iss 11, p e0241631 (2020)
The unique cellular organization and transparent function of the ocular lens depend on the continuous differentiation of immature epithelial cells on the lens anterior surface into mature elongated fiber cells within the lens core. A ubiquitous event