Disentangling the genetics of lean mass.

Autor: Karasik D; Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA.; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel., Zillikens MC; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands., Hsu YH; Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA., Aghdassi A; Department of Medicine A, University of Greifswald, Greifswald, Germany., Akesson K; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Department of Orthopedics, Skåne University Hospital, Malmö, Sweden., Amin N; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Barroso I; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.; NIHR Cambridge Biomedical Research Centre.; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL., Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany., Bochud M; University Institute for Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland., Borecki IB; Division of Statistical Genomics, Department of Genetics.; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO., Broer L; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Buchman AS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL., Byberg L; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Campbell H; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom., Campos-Obando N; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Cauley JA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA., Cawthon PM; California Pacific Medical Center Research Institute, San Francisco, CA., Chambers JC; Cardiology, Ealing Hospital NHS Trust, London, United Kingdom.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Imperial College Healthcare NHS Trust, London, United Kingdom.; NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, United Kingdom., Chen Z; Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ., Cho NH; Department of Preventive Medicine, Ajou University School of Medicine, Youngtong-Gu, Suwon, Korea., Choi HJ; Department of Internal Medicine.; Department of Anatomy and Cell Biology, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Korea.; Wide River Institute of Immunology, Seoul National University, Hongcheon, Korea., Chou WC; Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA.; Broad Institute, Cambridge, MA., Cummings SR; California Pacific Medical Center Research Institute, San Francisco, CA., de Groot LCPGM; Division of Human Nutrition, Wageningen University, AFSG, Wageningen, The Netherlands., De Jager PL; Center for Translational and Computational Neuroimmunology, Neurology, Columbia University Medical Center, New York, NY.; Cell Circuits Program, Broad Institute, Cambridge, MA., Demuth I; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany., Diatchenko L; Regional Center for Neurosensory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada., Econs MJ; Department of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN., Eiriksdottir G; Icelandic Heart Association Holtasmari, Kopavogur, Iceland., Enneman AW; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Eriksson J; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Eriksson JG; National Institute for Health and Welfare, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.; Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.; Folkhalsan Research Centre, Helsinki, Finland., Estrada K; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Translational Biology, Biogen, Cambridge, MA., Evans DS; California Pacific Medical Center Research Institute, San Francisco, CA., Feitosa MF; Division of Statistical Genomics, Department of Genetics., Fu M; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD., Gieger C; Research Unit of Molecular Epidemiology.; Institute of Epidemiology II.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Grallert H; Research Unit of Molecular Epidemiology.; Institute of Epidemiology II.; CCG Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany.; CCG Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany., Gudnason V; Icelandic Heart Association Holtasmari, Kopavogur, Iceland.; University of Iceland, Faculty of Medicine, Reykjavik, Iceland., Lenore LJ; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, NIA, Bethesda, MD., Hayward C; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, United Kingdom., Hofman A; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany., Huffman KM; Duke Molecular Physiology Institute and Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, NC., Husted LB; Aarhus University Hospital, Endocrinology and Internal Medicine, Aarhus, Denmark., Illig T; Research Unit of Molecular Epidemiology.; Department of Human Genetics, Hannover Medical School, Hanover, Germany., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA., Ittermann T; Institute for Community Medicine, University of Greifswald, Greifswald, Germany., Jansson JO; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Johnson T; University Institute for Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Biffar R; Centre of Oral Health, Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University of Greifswald, Greifswald, Germany., Jordan JM; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., Jula A; National Institute for Health and Welfare, Helsinki, Finland., Karlsson M; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Department of Orthopedics, Skåne University Hospital, Malmö, Sweden., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Kilpeläinen TO; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY., Klopp N; Research Unit of Molecular Epidemiology.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany., Kloth JSL; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Koller DL; Department of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN., Kooner JS; Cardiology, Ealing Hospital NHS Trust, London, United Kingdom.; Imperial College Healthcare NHS Trust, London, United Kingdom.; Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Campus, Hammersmith Hospital, Imperial College London, United Kingdom., Kraus WE; Duke Molecular Physiology Institute and Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC., Kritchevsky S; Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, NC., Kutalik Z; University Institute for Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Kuulasmaa T; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lahti J; Helsinki Collegium Advanced Studies, University of Helsinki, Helsinki, Finland., Lang T; Department of Radiology and Biomedical Imaging, and School of Dentistry, UC San Francisco, San Francisco, CA., Langdahl BL; Aarhus University Hospital, Endocrinology and Internal Medicine, Aarhus, Denmark., Lerch MM; Department of Medicine A, University of Greifswald, Greifswald, Germany., Lewis JR; School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.; Centre for Kidney Research, Children's Hospital at Westmead, School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia., Lill C; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany., Lind L; Department. of Medical Sciences, Uppsala University, Uppsala, Sweden., Lindgren C; Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom., Liu Y; Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC., Livshits G; Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, London, United Kingdom., Ljunggren Ö; Department. of Medical Sciences, Uppsala University, Uppsala, Sweden., Loos RJF; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY.; The Charles Bronfman Institute of Personalized Medicine.; Institute of Child Health and Development.; The Genetics of Obesity and Related Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY., Lorentzon M; Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Luan J; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY., Luben RN; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Malkin I; Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., McGuigan FE; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Medina-Gomez C; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Meitinger T; Institute of Human Genetics, MRI, Technische Universität München, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Melhus H; Department. of Medical Sciences, Uppsala University, Uppsala, Sweden., Mellström D; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Michaëlsson K; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Mitchell BD; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD.; Geriatric Research and Education Clinical Center-Veterans Administration Medical Center, Baltimore, MD., Morris AP; Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom.; Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom., Mosekilde L; Aarhus University Hospital, Endocrinology and Internal Medicine, Aarhus, Denmark., Nethander M; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Newman AB; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA., O'Connell JR; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD., Oostra BA; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.; Centre for Medical Systems Biology & Netherlands Consortium on Healthy Aging, Leiden, The Netherlands., Orwoll ES; Oregon Health & Science University, Portland, OR., Palotie A; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland., Peacock M; Department of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN., Perola M; National Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki, Institute for Molecular Medicine, Finland and Diabetes and Obesity Research Program, Helsinki, Finland.; University of Tartu, Estonian Genome Center, Tartu, Estonia., Peters A; Research Unit of Molecular Epidemiology.; Institute of Epidemiology II., Prince RL; School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.; Department of Endocrinology and Diabetes, Sir Charles Gardiner Hospital, Perth, Australia., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA., Räikkönen K; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Ralston SH; Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom., Ripatti S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Hjelt Institute, University of Helsinki, Helsinki, Finland., Rivadeneira F; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Robbins JA; Department of Medicine, University California at Davis, Sacramento, CA., Rotter JI; Institute for Translational Genomic and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA., Rudan I; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Satterfield S; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN., Schipf S; Institute for Community Medicine, University of Greifswald, Greifswald, Germany., Shin CS; Department of Internal Medicine., Smith AV; Icelandic Heart Association Holtasmari, Kopavogur, Iceland.; University of Iceland, Faculty of Medicine, Reykjavik, Iceland., Smith SB; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC., Soranzo N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, London, United Kingdom., Stancáková A; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Stefansson K; University of Iceland, Faculty of Medicine, Reykjavik, Iceland.; deCODE Genetics, Reykjavik, Iceland., Steinhagen-Thiessen E; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Stolk L; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands., Streeten EA; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD.; Geriatric Research and Education Clinical Center-Veterans Administration Medical Center, Baltimore, MD., Styrkarsdottir U; deCODE Genetics, Reykjavik, Iceland., Swart KMA; Department of Epidemiology and Biostatistics, and the EMGO+ Institute; VU University Medical Center, Amsterdam, The Netherlands., Thompson P; Department of Pathology, Stony Brook University, Stony Brook, NY., Thomson CA; Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Thorsteinsdottir U; University of Iceland, Faculty of Medicine, Reykjavik, Iceland.; deCODE Genetics, Reykjavik, Iceland., Tikkanen E; National Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Tranah GJ; California Pacific Medical Center Research Institute, San Francisco, CA., Uitterlinden AG; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Centre for Medical Systems Biology & Netherlands Consortium on Healthy Aging, Leiden, The Netherlands., van Schoor NM; Department of Epidemiology and Biostatistics, and the EMGO+ Institute; VU University Medical Center, Amsterdam, The Netherlands., Vandenput L; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland., Völzke H; Institute for Community Medicine, University of Greifswald, Greifswald, Germany., Wactawski-Wende J; Department of Epidemiology and Environmental Health, University at Buffalo, SUNY, Buffalo, NY., Walker M; Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, United Kingdom., J Wareham N; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Waterworth D; Genetics, GlaxoSmithKline, King of Prussia, PA., Weedon MN; Genetics of Complex Traits, Royal Devon & Exeter Hospital, University of Exeter Medical School, Exeter, United Kingdom., Wichmann HE; Institute of Epidemiology II.; Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Neuherberg/Munich, Germany.; Institute of Medical Statistics and Epidemiology, Technical University, Munich, Germany., Widen E; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Williams FMK; Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, London, United Kingdom., Wilson JF; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom., Wright NC; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL., Yerges-Armstrong LM; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD.; Genetics, GlaxoSmithKline, King of Prussia, PA., Yu L; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL., Zhang W; Cardiology, Ealing Hospital NHS Trust, London, United Kingdom.; Imperial College Healthcare NHS Trust, London, United Kingdom., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Zhou Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Nielson CM; Oregon Health & Science University, Portland, OR., Harris TB; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, NIA, Bethesda, MD., Demissie S; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Kiel DP; Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Ohlsson C; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Publikováno v: The American journal of clinical nutrition [Am J Clin Nutr] 2019 Feb 01; Vol. 109 (2), pp. 276-287.