Interindividual Differences in Human Intestinal Microbial Conversion of (-)-Epicatechin to Bioactive Phenolic Compounds

Autor: Chen Liu, Marta Baccaro, Jacques Vervoort, Karsten Beekmann, Sebas Wesseling, Ivonne M.C.M. Rietjens, Lenny Kamelia

Publikováno v: Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry 68 (2020) 48
Journal of Agricultural and Food Chemistry, 68(48), 14168-14181

To quantify interindividual differences in the human intestinal microbial metabolism of (-)-epicatechin (EC), in vitro anaerobic incubations with fecal inocula from 24 healthy donors were conducted. EC-derived colonic microbial metabolites were quali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af32500d0921bd5be396114d23adb70
https://doi.org/10.1021/acs.jafc.0c05890

Developmental toxicity testing of unsubstituted and methylated 4- and 5-ring polycyclic aromatic hydrocarbons using the zebrafish embryotoxicity test

Autor: Jing Fang, Shutong Dong, Peter J. Boogaard, Ivonne M.C.M. Rietjens, Lenny Kamelia

Publikováno v: Toxicology in Vitro 80 (2022)
Toxicology in Vitro, 80

The present study evaluates the in vitro developmental toxicity of 4- and 5-ring polycyclic aromatic hydrocarbons (PAHs) including benz[a]anthracene (BaA) and benzo[a]pyrene (BaP) and six of their monomethylated congeners, and dibenz[a,h]anthracene (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4a069b5e891b51242c42ae37770a4d
https://pubmed.ncbi.nlm.nih.gov/35033653

Comparison of PAC and MOAH for understanding the carcinogenic and developmental toxicity potential of mineral oils

Autor: Juan-Carlos Carrillo, Lenny Kamelia, Julija Romanuka, Olaf Kral, Allison Isola, Helena Niemelä, Anna Steneholm

Publikováno v: Regulatory Toxicology and Pharmacology. 132:105193

The carcinogenicity and developmental toxicity of unrefined mineral oil is related to its 3-7 ring polycyclic aromatic compounds (PAC) content. Therefore, refining operations focus on the targeted removal PAC from mineral oil that may contain aromati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c712f03ff9a540f233713f5c09a0b7
https://doi.org/10.1016/j.yrtph.2022.105193

Assessment of the in vitro developmental toxicity of diethylstilbestrol and estradiol in the zebrafish embryotoxicity test

Autor: Aziza Hussein Bakheit Adam, Lenny Kamelia, Jochem Louisse, Ivonne M.C.M. Rietjens, Laura H.J. de Haan

Publikováno v: Toxicology in Vitro 72 (2021)
Toxicology in Vitro, 72

The present study investigated the developmental toxicity of diethylstilbestrol (DES) in the zebrafish embryotoxicity test (ZET). This was done to investigate whether the ZET would better capture the developmental toxicity of DES than the embryonic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c2ef32d2d0f5cf3892850c3e881082
https://pubmed.ncbi.nlm.nih.gov/33429043

Developmental toxicity testing of the fume condensate extracts of bitumen and oxidized asphalt in a series of in vitro alternative assays

Autor: Lenny Kamelia, Peter J. Boogaard, Ivonne M.C.M. Rietjens

Publikováno v: Toxicology in Vitro, 75
Toxicology in Vitro 75 (2021)

The potential developmental toxicity and mode-of-action of fume condensate extracts of bitumen and oxidized asphalt were evaluated in the aryl hydrocarbon receptor (AhR) CALUX assay, the zebrafish embryotoxicity test (ZET), and the mouse embryonic st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f05f5d8d62b4e382d16a7b830a167d
https://doi.org/10.1016/j.tiv.2021.105195