Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lenny Guarente"'
Autor:
Yuancheng Lu, Lindsay E. Wu, James R. Mitchell, Lenny Guarente, David A. Sinclair, Abhirup Das, Michael Bonkowski, Michael B. Schultz
With aging there is a notable decline in capillary density and blood flow contributing to mortality and morbidity. The use of NAD+ boosters to reverse aspects of aging, is in part, through the mechanism of activating sirtuin deacylases (SIRT1–SIRT7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626844c0dd6ab4ddc7f4d3cdde688492
https://europepmc.org/articles/PMC6227600/
https://europepmc.org/articles/PMC6227600/
Autor:
D Shawn, David A. Sinclair, Jaime M. Reyes, Yuancheng Lu, Lenny Guarente, Michael B. Schultz, Michael Bonkowski
Suppressed neuroendocrine signaling is a common trait in many long-lived mouse mutants and mice on calorie restriction. Loss-of-function mutations in the pituitary Pit1 and Prop1 genes in Snell and Ames dwarf mice were the first mutations known to ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1444522567a9e1f739385f4ff0c8ff
https://europepmc.org/articles/PMC6229477/
https://europepmc.org/articles/PMC6229477/
Autor:
Foteini Orfaniotou, Wiebke Möbius, Marina Uecker, Olaf Jahn, Ajit S Dhaunchak, Katja Kuhlmann, Siming Shen, Kalina Dimova, Anke Schardt, Lenny Guarente, Bastian G. Brinkmann, Klaus-Armin Nave, Patrizia Casaccia-Bonnefil, Hauke B. Werner
Publikováno v:
The Journal of Neuroscience. 27:7717-7730
Mice lacking the expression of proteolipid protein (PLP)/DM20 in oligodendrocytes provide a genuine model for spastic paraplegia (SPG-2). Their axons are well myelinated but exhibit impaired axonal transport and progressive degeneration, which is dif
Autor:
Lenny Guarente, David A. Sinclair
Publikováno v:
Scientific American. 294:48-57