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Akademický článek

Modified streptozotocin‐induced diabetic model in rodents

Autor: Anton Lennikov, Farris ElZaridi, Menglu Yang

Publikováno v: Animal Models and Experimental Medicine, Vol 7, Iss 5, Pp 777-780 (2024)

Abstract Streptozotocin (STZ)‐induced type I diabetes mellitus (DM) models have been pivotal in diabetes research due to their ability to mimic the insulin‐dependent hyperglycemia akin to human type I diabetes. However, these models often suffer

Externí odkaz: https://doaj.org/article/638ac017290d4ee7b31d734f34089bb6

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Akademický článek

Preservation of vision by transpalpebral electrical stimulation in mice with inherited retinal degeneration

Autor: Kasim Gunes, Karen Chang, Anton Lennikov, Wai Lydia Tai, Julie Chen, Farris ElZaridi, Kin-Sang Cho, Tor Paaske Utheim, Chen Dong Feng

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

IntroductionThe potential neuroprotective and regenerative properties of electrical stimulation (ES) were studied in rhodopsin knockout mice (Rho−/−), a murine model of inherited retinal degeneration. The study focused on assessing the impact of

Externí odkaz: https://doaj.org/article/0ae625ffcc364309a5b97827f25dc833

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Akademický článek

Optimal transcorneal electrical stimulation parameters for preserving photoreceptors in a mouse model of retinitis pigmentosa

Autor: Sam Enayati, Karen Chang, Anton Lennikov, Menglu Yang, Cherin Lee, Ajay Ashok, Farris Elzaridi, Christina Yen, Kasim Gunes, Jia Xie, Kin-Sang Cho, Tor Paaske Utheim, Dong Feng Chen

Publikováno v: Neural Regeneration Research, Vol 19, Iss 11, Pp 2543-2552 (2024)

Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors, leading to progressive photoreceptor loss. Previous research supports the beneficial effect of electrical stimulation on photoreceptor survival. This study

Externí odkaz: https://doaj.org/article/2c8efc2702d941ef8c1a490a026008cb

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Akademický článek

Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance

Autor: Aya Ushio, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Akihide Shimizu, Abdalla Abdelmaksoud, Michael C. Kelly, Naozumi Ishimaru, Yousuke Takahama

Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 114072- (2024)

Summary: Medullary thymic epithelial cells (mTECs) are essential for the establishment of self-tolerance in T cells. Promiscuous gene expression by a subpopulation of mTECs regulated by the nuclear protein Aire contributes to the display of self-geno

Externí odkaz: https://doaj.org/article/7078fd472f85403aa1d52ace8be585dd

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