Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Lenne J M Lemmens"'
1
Switchable Control of Scaffold Protein Activity via Engineered Phosphoregulated Autoinhibition
Autor: Arjan Hazegh Nikroo, Lenne J. M. Lemmens, Tim Wezeman, Christian Ottmann, Maarten Merkx, Luc Brunsveld
Publikováno v: ACS Synthetic Biology, 11(7), 2464-2472. American Chemical Society
Scaffold proteins operate as organizing hubs to enable high-fidelity signaling, fulfilling crucial roles in the regulation of cellular processes. Bottom-up construction of controllable scaffolding platforms is attractive for the implementation of reg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b309dd85f54ecda8bcec0a86d413ecf8
https://doi.org/10.1021/acssynbio.2c00122
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3
Designed asymmetric protein assembly on a symmetric scaffold
Autor: Luc Brunsveld, Lenne J M Lemmens, Job A.L. Roodhuizen, Tom F. A. de Greef, Albert J. Markvoort
Publikováno v: Angewandte Chemie, 132(29). Wiley-VCH Verlag
Angewandte Chemie (International Ed. in English)
Angewandte Chemie. International Edition, 59, 12113-12121
Angewandte Chemie-International Edition, 59(29), 12113-12121. Wiley
Angewandte Chemie
Angewandte Chemie. International Edition, 59, 29, pp. 12113-12121
Cellular signaling is regulated by the assembly of proteins into higher‐order complexes. Bottom‐up creation of synthetic protein assemblies, especially asymmetric complexes, is highly challenging. Presented here is the design and implementation o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c5ceb0cb1e0148da9d7c7eb0caeda4
https://research.tue.nl/en/publications/9f986852-4600-4549-9c9b-b0102deb9638
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4
Modular bioengineered kinase sensorsviascaffold protein-mediated split-luciferase complementation
Autor: Xiaolu Xu, Lenne J M Lemmens, Maarten Merkx, Christian Ottmann, Anniek den Hamer, Luc Brunsveld
Publikováno v: Chemical Science, 11(21), 5532-5536. Royal Society of Chemistry
Phosphorylation is a key regulation event in cellular signaling. Sensing the underlying kinase activity is of crucial importance for its fundamental understanding and for drug development. For this, modular kinase activity sensing concepts are urgent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb970c830c51a1159834aadb2c1dd7f5
https://doi.org/10.1039/d0sc00074d
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5
Conjugated protein domains as engineered scaffold proteins
Autor: Lenne J M Lemmens, Luc Brunsveld, Christian Ottmann
Publikováno v: Bioconjugate Chemistry, 31(6), 1596-1603. American Chemical Society
Bioconjugate Chemistry
Assembly of proteins into higher-order complexes generates specificity and selectivity in cellular signaling. Signaling complex formation is facilitated by scaffold proteins that use modular scaffolding domains, which recruit specific pathway enzymes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d037a8768e0e02dfdd069886503f88
https://research.tue.nl/nl/publications/25d6b3c7-a88f-4ad1-8e37-ecd1bfdc42a7
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6
Protease-activatable scaffold proteins as versatile molecular hubs in synthetic signaling networks
Autor: Maarten Merkx, Simone F A Wouters, Sja Stijn Aper, Luc Brunsveld, Christian Ottmann, Lenne J M Lemmens, Anniek den Hamer
Publikováno v: ACS Synthetic Biology, 7(9), 2216-2225. American Chemical Society
Protease signaling and scaffold-induced control of protein-protein interactions represent two important mechanisms for intracellular signaling. Here we report a generic and modular approach to control the activity of scaffolding proteins by protease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6ac65384945c3297a56d5b8f6fd16d
https://doi.org/10.1021/acssynbio.8b00217
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