Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Lennart Opitz"'
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105240- (2024)
Summary: Background: Humanized tumour models could be particularly valuable for cancer immunotherapy research, as they may better reflect human-specific aspects of the interfaces between tumour and immune system of human cancer. However, endogenous a
Externí odkaz:
https://doaj.org/article/97362e817bc54a9186814285396df9bd
Autor:
Sereina Deplazes, Andrea Schlegel, Zhuolun Song, Gabriella Allegri, Nicole Rimann, Tanja Scherer, Melanie Willimann, Lennart Opitz, Sharon C. Cunningham, Ian E. Alexander, Anja Kipar, Johannes Häberle, Beat Thöny, Hiu Man Grisch-Chan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 352-367 (2022)
Hydrodynamic tail vein injection (HTV) is the “gold standard” for delivering naked DNA vectors to mouse liver, thereby transfecting predominately perivenous hepatocytes. While HTV corrects metabolic liver defects such as phenylketonuria or cystat
Externí odkaz:
https://doaj.org/article/334928f0d4ad4afba5bcb442c5af482b
Autor:
Harsha V. Renikunta, Katina Lazarow, Yiqi Gong, Praphulla Chandra Shukla, Vanasa Nageswaran, Hector Giral, Adelheid Kratzer, Lennart Opitz, Felix B. Engel, Arash Haghikia, Sarah Costantino, Francesco Paneni, Jens Peter von Kries, Katrin Streckfuss-Bömeke, Ulf Landmesser, Philipp Jakob
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106593- (2023)
Summary: Ischemic cardiomyopathy, driven by loss of cardiomyocytes and inadequate proliferative response, persists to be a major global health problem. Using a functional high-throughput screening, we assessed differential proliferative potential of
Externí odkaz:
https://doaj.org/article/0397c180ca2842079b4aa0e59e2381c0
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The main obstacle to cure HIV-1 is the latent reservoir. Antiretroviral therapy effectively controls viral replication, however, it does not eradicate the latent reservoir. Latent CD4+ T cells are extremely rare in HIV-1 infected patients, making pri
Externí odkaz:
https://doaj.org/article/aff97d86d87a4ae484b3cf27ee546180
Autor:
Alexander Laure, Angelica Rigutto, Michaela B. Kirschner, Lennart Opitz, Linda Grob, Isabelle Opitz, Emanuela Felley-Bosco, Stefanie Hiltbrunner, Alessandra Curioni-Fontecedro
Publikováno v:
Cancers, Vol 15, Iss 10, p 2813 (2023)
Cell lines are extensively used to study cancer biology. However, the use of highly passaged commercial cell lines has to be questioned, as they do not closely resemble the originating tumor. To understand the reliability of preclinical models for Ma
Externí odkaz:
https://doaj.org/article/4d404c809e0b4b83b26f98a5edcdda69
Autor:
Andreas Müller, Patrick Weyerhäuser, Nancy Berte, Fitriasari Jonin, Bogdan Lyubarskyy, Bettina Sprang, Sven Rainer Kantelhardt, Gabriela Salinas, Lennart Opitz, Walter Schulz-Schaeffer, Alf Giese, Ella L. Kim
Publikováno v:
Cells, Vol 12, Iss 9, p 1290 (2023)
Lysosomotropic agent chloroquine was shown to sensitize non-stem glioblastoma cells to radiation in vitro with p53-dependent apoptosis implicated as one of the underlying mechanisms. The in vivo outcomes of chloroquine or its effects on glioblastoma
Externí odkaz:
https://doaj.org/article/386ad53bcbfe46bab387cbef13ee2a67
Autor:
Chaoran Chen, Sarah Ann Nadeau, Ivan Topolsky, Marc Manceau, Jana S. Huisman, Kim Philipp Jablonski, Lara Fuhrmann, David Dreifuss, Katharina Jahn, Christiane Beckmann, Maurice Redondo, Christoph Noppen, Lorenz Risch, Martin Risch, Nadia Wohlwend, Sinem Kas, Thomas Bodmer, Tim Roloff, Madlen Stange, Adrian Egli, Isabella Eckerle, Laurent Kaiser, Rebecca Denes, Mirjam Feldkamp, Ina Nissen, Natascha Santacroce, Elodie Burcklen, Catharine Aquino, Andreia Cabral de Gouvea, Maria Domenica Moccia, Simon Grüter, Timothy Sykes, Lennart Opitz, Griffin White, Laura Neff, Doris Popovic, Andrea Patrignani, Jay Tracy, Ralph Schlapbach, Emmanouil T. Dermitzakis, Keith Harshman, Ioannis Xenarios, Henri Pegeot, Lorenzo Cerutti, Deborah Penet, Anthony Blin, Melyssa Elies, Christian L. Althaus, Christian Beisel, Niko Beerenwinkel, Martin Ackermann, Tanja Stadler
Publikováno v:
Epidemics, Vol 37, Iss , Pp 100480- (2021)
Background: In December 2020, the United Kingdom (UK) reported a SARS-CoV-2 Variant of Concern (VoC) which is now named B.1.1.7. Based on initial data from the UK and later data from other countries, this variant was estimated to have a transmission
Externí odkaz:
https://doaj.org/article/bd41319829ad4201b8f18a7bf5efe47f
Autor:
Veronika Haunerdinger, Maria Domenica Moccia, Lennart Opitz, Stefano Vavassori, Hitendu Dave, Mathias M. Hauri-Hohl
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Thymic epithelial cells (TECs) are essential in supporting the development of mature T cells from hematopoietic progenitor cells and facilitate their lineage-commitment, proliferation, T-cell receptor repertoire selection and maturation. While animal
Externí odkaz:
https://doaj.org/article/5c08c2b556994e40877c0d13dba10de5
Autor:
Seraina Prader, Nicole Ritz, Frédéric Baleydier, Maya C. Andre, Noémie Stähli, Kevin Schmid, Hanna Schmid, Andreas Woerner, Tamara Diesch, Patrick M. Meyer Sauteur, Johannes Trück, Fabienne Gebistorf, Lennart Opitz, Michael P. Killian, Tommaso Marchetti, Stefano Vavassori, Géraldine Blanchard-Rohner, Valerie Mc Lin, Serge Grazioli, Jana Pachlopnik Schmid
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Most children with a SARS-CoV-2 infection are asymptomatic or exhibit mild symptoms. However, a small number of children develop features of substantial inflammation temporarily related to the COVID-19 also called multisystem inflammatory syndrome in
Externí odkaz:
https://doaj.org/article/cbd380dbb52849c9a76aad4a279f95f7
Autor:
Pei Jin Lim, Severin Marfurt, Uschi Lindert, Lennart Opitz, Timothée Ndarugendamwo, Pakeerathan Srikanthan, Martin Poms, Martin Hersberger, Claus-Dieter Langhans, Dorothea Haas, Marianne Rohrbach, Cecilia Giunta
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Osteogenesis imperfecta (OI) is an inherited skeletal dysplasia characterized by low bone density, bone fragility and recurrent fractures. The characterization of its heterogeneous genetic basis has allowed the identification of novel players in bone
Externí odkaz:
https://doaj.org/article/9bee465ed539427a92a499a68432087a