Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lennart Nicke"'
Autor:
Mark D. Ericson, Courtney M. Larson, Katie T. Freeman, Lennart Nicke, Armin Geyer, Carrie Haskell-Luevano
Publikováno v:
ACS Omega. 7:27656-27663
The melanocortin family is involved in many physiological functions, including pigmentation, steroidogenesis, and appetite. The centrally expressed melanocortin-3 and melanocortin-4 receptors (MC3R and MC4R) possess overlapping but distinct roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede43522fcaf6f5fccad13986b63abb2
https://doi.org/10.1021/acsomega.2c03307
https://doi.org/10.1021/acsomega.2c03307
Publikováno v:
Chembiochem
A generalized synthetic strategy is proposed here for the synthesis of asymmetric β‐indoylated amino acids by 8‐aminoquinoline (8AQ)‐directed C(sp3)‐H functionalization of suitably protected precursors. Peptides containing one of the four st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70664880c0d429e0ae2fd5a2d2e204e9
https://doi.org/10.1002/cbic.202000424
https://doi.org/10.1002/cbic.202000424
Publikováno v:
Chemical Science. 10:8634-8641
The 8-aminoquinoline (8AQ) directed C(sp3)-H functionalization was applied in the synthesis of β-arylated tryptophan derivatives. The laborious protecting group reorganization towards α-amino acids compatible for solid phase peptide synthesis (SPPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52a0979a1fbd9b73b40adeafeff295e9
https://doi.org/10.1039/c9sc03440d
https://doi.org/10.1039/c9sc03440d
Autor:
Lennart Nicke, Nicole Reisch, Katrin Koehler, André Schanze, Angela Huebner, Tina Schubert, Armin Geyer
Publikováno v:
Journal of the Endocrine Society
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by different enzyme deficiencies in the steroid hormone synthesis leading to a disturbed cortisol biosynthesis. The medical treatment of CAH includes suboptimal ACTH-suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e773f0b873f83a7734dd6f3f5474500
http://europepmc.org/articles/PMC7209623
http://europepmc.org/articles/PMC7209623
Publikováno v:
Chemical Science
The aminoquinoline-directed C–H activation was used to synthezise unnatural tryptophans for solid phase peptide synthesis for the first time.
The 8-aminoquinoline (8AQ) directed C(sp3)–H functionalization was applied in the synthesis of β-a
The 8-aminoquinoline (8AQ) directed C(sp3)–H functionalization was applied in the synthesis of β-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3873b12de1e249fcbefe411dedcda72
https://pubmed.ncbi.nlm.nih.gov/31803437
https://pubmed.ncbi.nlm.nih.gov/31803437
Publikováno v:
Chemmedchem
We describe two synthetic amino acids with inverted side chain stereochemistry, which induce opposite biological activity. Phe4 is an important part of the activation motif of ghrelin, and in short peptide inverse agonists such as KwFwLL‐NH2, the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82a9ab31226551cabe09a6ccfb619fa
https://pubmed.ncbi.nlm.nih.gov/31442005
https://pubmed.ncbi.nlm.nih.gov/31442005
Autor:
Maren Nattermann, Sebastian Wenk, Pascal Pfister, Hai He, Seung Hwan Lee, Witold Szymanski, Nils Guntermann, Fayin Zhu, Lennart Nickel, Charlotte Wallner, Jan Zarzycki, Nicole Paczia, Nina Gaißert, Giancarlo Franciò, Walter Leitner, Ramon Gonzalez, Tobias J. Erb
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Formate can be envisioned at the core of a carbon-neutral bioeconomy, where it is produced from CO2 by (electro-)chemical means and converted into value-added products by enzymatic cascades or engineered microbes. A key step in expanding syn
Externí odkaz:
https://doaj.org/article/e3ea1543e7bb47f085fc0b1f3974546b
Autor:
Javier Duran, Lennart Nickel, Manuel Estrada, Johannes Backs, Maarten M. G. van den Hoogenhof
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
RNA splicing has been recognized in recent years as a pivotal player in heart development and disease. The Ca2+/calmodulin dependent protein kinase II delta (CaMKIIδ) is a multifunctional Ser/Thr kinase family and generates at least 11 different spl
Externí odkaz:
https://doaj.org/article/6bda3640f8a44476b4eefcee3c4e162b