Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lennart Lykke"'
Autor:
Thomas Hoeg-Jensen, Rita Slaaby, Thomas Kruse, Christian Lehn Brand, Jeppe Sturis, Christian Fledelius, Peter Nielsen, Erica Nishimura, Alice Madsen, Lennart Lykke, Kim Halskov, Simona Koscova, Vladaslav Kotek, Anthony Davis, Robert Tromans, Michael Tomsett, Guillem Penuelas-Haro, Daniel J. Leonard, Michael Orchard, Andy Chapman, Gaetano Invernizzi, Eva Johansson, Daniele Granata, Bo Hansen, Thomas Pedersen, Jonas Kildegaard, Karen Pedersen, Hanne Refsgaard, Lene Alirangis, Johannes Fels, Anita Neutzsky-Wulff, Per Sauerberg
The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes. Insulin doses must be adjusted to ensure blood glucose values within normal range, but matching insulin doses to fluct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9f11fc10aa8b4da1245021a1cf15e84
https://doi.org/10.21203/rs.3.rs-2882397/v1
https://doi.org/10.21203/rs.3.rs-2882397/v1
Autor:
Tina M. Tagmose, Karen-Margrethe Pedersen, Lone Pridal, Carsten E. Stidsen, Marie Ø. Pedersen, Zhaosheng Lin, Yuanyuan Zhang, Zhe Wan, Mercedes Ferreras, Helle Naver, Peter K. Nielsen, Zheng Cao, Yi Wang, Lennart Lykke, Josefine L. Christensen, Victoria S. Jensen, Valentina Manfè, Thomas Å. Pedersen, Eva Johansson, Peter Madsen, János T. Kodra, Martin Münzel, Leonardo De Maria, Erica Nishimura, Thomas B. Kjeldsen
Publikováno v:
Journal of Medicinal Chemistry. 65:2633-2645
Here, we describe molecular engineering of monovalent ultra-long acting two-chain insulin-Fc conjugates. Insulin-Fc conjugates were synthesized using trifunctional linkers with one amino reactive group for reaction with a lysine residue of insulin an
Autor:
Sandra-Maria Wienhold, Lennart Lykke, Katrin Reppe, Martin Witzenrath, Peter H. Seeberger, Madhu Emmadi, Marilda P. Lisboa, Claney L. Pereira, Sharavathi Guddehalli Parameswarappa, Naeem Khan
Publikováno v:
Journal of the American Chemical Society. 139:14783-14791
Invasive pneumococcal diseases (IPDs) remain the leading cause of vaccine-preventable childhood death, even though highly effective pneumococcal conjugate vaccines (PCVs) are used in national immunization programs in many developing countries. Licens
Publikováno v:
Lykke, L, Esrich, C R & Jørgensen, K A 2011, ' Catalytic Enantioselective Oxaziridination ', Journal of the American Chemical Society, vol. 133, no. 38, pp. 14932-14935 . https://doi.org/10.1021/ja2064457
The first catalytic enantioselective synthesis of oxaziridines is presented. The oxidation of aryl and alkyl aldimines with m-CPBA under organocatalytic conditions using cinchona alkaloid-derived catalysts furnished optically active oxaziridines in g
Publikováno v:
Monge, D, Jensen, K L, Franke, P T, Lykke, L & Jørgensen, K A 2010, ' Asymmetric One-Pot Sequential Organo-and Gold Catalysis for the Enantioselective Synthesis of Dihydropyrrole Derivatives ', Chemistry: A European Journal, vol. 16, no. 31, pp. 9478-9484 .
A direct asymmetric one-pot synthesis of optically active 2,3-dihy- dropyrroles from propargylated malo- nonitrile and N-Boc-protected (Boc = tert-butoxycarbonyl) imines is present- ed. The approach is based on a bifunc- tional organocatalytic Mannic
Publikováno v:
ChemInform. 45
α,β-Unsaturated aldehydes with conjugated substituents as well as unsaturated alkyl chains give unsatisfactory results.
Publikováno v:
Sibbersen, C, Lykke, L, Gregersen, N, Jørgensen, K A & Johannsen, M 2014, ' A cleavable azide resin for direct click chemistry mediated enrichment of alkyne-labeled proteins ', Chemical Communications, vol. 50, no. 81, pp. 12098-12100 . https://doi.org/10.1039/c4cc05246c
The direct conjugation of a labeled proteome to a cleavable azide resin utilizing the copper-catalyzed azide alkyne cycloaddition is demonstrated. The procedure omits the classical streptavidin- and biotin-based affinity enrichment step and represent
Publikováno v:
Lykke, L, Carlsen, B D, Rambo, R S & Jørgensen, K A 2014, ' Catalytic asymmetric synthesis of 4-nitropyrazolidines: An access to optically active 1,2,3-triamines ', Journal of the American Chemical Society, vol. 136, no. 32, pp. 11296-11299 . https://doi.org/10.1021/ja506694v
The first catalytic enantio- and diastereoselective synthesis of 4-nitropyrazolidines is presented. Asymmetric hydrogen-bonding activation of nitro-olefins facilitated the 1,3-dipolar cycloaddition with hydrazones, affording optically active 4-nitrop
Publikováno v:
Ransborg, L K, Lykke, L, Hammer, N, Næsborg, L & Jørgensen, K A 2014, ' An organocatalytic one-pot cascade incorporating the Achmatowicz reaction affording 3-pyrone derivatives ', Chemical Communications, vol. 50, no. 57, pp. 7604-7606 . https://doi.org/10.1039/C4CC03815K
The development of an organocatalytic one-pot cascade for the annulation of simple starting materials: α,β-unsaturated aldehydes, hydrogen peroxide, β-carbonyl compounds and NBS to furnish optically active 3-pyrones in good yield and with excellen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2813ca419d296fd9efa574fba84c625
https://pure.au.dk/portal/da/publications/an-organocatalytic-onepot-cascade-incorporating-the-achmatowicz-reaction-affording-3pyrone-derivatives(f66f60e1-a895-4314-98c0-857dd353532f).html
https://pure.au.dk/portal/da/publications/an-organocatalytic-onepot-cascade-incorporating-the-achmatowicz-reaction-affording-3pyrone-derivatives(f66f60e1-a895-4314-98c0-857dd353532f).html
Autor:
Kim Soeholm Halskov, Victor X. Chen, Bjørn Dreiø Carlsen, Karl Anker Joergensen, Lennart Lykke
Publikováno v:
ChemInform. 44