Výsledky vyhledávání - "Lennart Holterman"

Akademický článek

Direct Amplification and Cloning of Up to 5-kb Lentivirus Genomes from Serum

Autor: Lennart Holterman, James I. Mullins, Joost J. Haaijman, Jonathan L. Heeney

Publikováno v: BioTechniques, Vol 21, Iss 2, Pp 312-319 (1996)

To produce large cDNA strands from biological samples containing limited numbers of template molecules, it may be necessary to minimize both nonspecific primer attachment in first-strand synthesis and secondary structure in RNA molecules. Failure to

Externí odkaz: https://doaj.org/article/84edcdee957c48d597198612e6e75959

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Differential Antigen Requirements for Protection against Systemic and Intranasal Vaccinia Virus Challenges in Mice

Autor: Genoveffa Franchini, Ayush Giri, Menzo J. E. Havenga, Jaap Goudsmit, Lennart Holterman, Colleen Devoy, Lauren E. Grandpre, Matthew Denholtz, Dan H. Barouch, Bonnie A. Ewald, David R. Kaufman, Michael S. Seaman, Jean-Michel Heraud

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2008, 82 (14), pp.6829-6837. ⟨10.1128/jvi.00353-08⟩
Journal of virology, 82(14), 6829-6837. American Society for Microbiology

The development of a subunit vaccine for smallpox represents a potential strategy to avoid the safety concerns associated with replication-competent vaccinia virus. Preclinical studies to date with subunit smallpox vaccine candidates, however, have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822d4a9c1037bbf51295938910706bc7
https://doi.org/10.1128/jvi.00353-08

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Serum-free transient protein production system based on adenoviral vector and PER.C6 technology: high yield and preserved bioactivity

Autor: R. van der Vlugt, Lennart Holterman, Jaap Goudsmit, Menzo J. E. Havenga, Martin H. Koldijk, Jorn Kaspers, Guus Hateboer, E. Heemskerk, Ronald Vogels, Shirley Smits, I. Melis, K. Brouwer, Govert Johan Schouten

Publikováno v: Biotechnology and Bioengineering
Biotechnology and bioengineering, 100(2), 273-283. Wiley-VCH Verlag

Stable E1 transformed cells, like PER.C6, are able to grow at scale and to high cell densities. E1‐deleted adenoviruses replicate to high titer in PER.C6 cells whereas subsequent deletion of E2A from the vector results in absence of replication in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3a32e83ef4ce79caf18ab0d9255a46
https://doi.org/10.1002/bit.21757

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Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D

Autor: Dan H. Barouch, Keith G. Mansfield, Bonnie A. Ewald, Anna R. Thorner, Peter Abbink, Kara L. O'Brien, Angela Carville, Ronald Vogels, Shirley Smits, Angelique A. C. Lemckert, Lennart Holterman, Irma Damen, Jaap Goudsmit, Diana M. Lynch, Matthew Denholtz, Menzo J. E. Havenga

Publikováno v: Journal of virology, 81(9), 4654-4663. American Society for Microbiology

Recombinant adenovirus serotype 5 (rAd5) vector-based vaccines are currently being developed for both human immunodeficiency virus type 1 and other pathogens. The potential limitations associated with rAd5 vectors, however, have led to the constructi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d8bc90b67b1322a40e299ff905fd88
https://doi.org/10.1128/jvi.02696-06

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Increased immunogenicity of recombinant Ad35-based malaria vaccine through formulation with aluminium phosphate adjuvant

Autor: Menzo J. E. Havenga, J.M. Klap, Jaap Goudsmit, Katarina Radosevic, Olga J.A.E Ophorst, Gert Gillissen, Lennart Holterman, Ratna Mintardjo, Mark J.M. van Ooij, Arjen Companjen, Jeroen Sijtsma

Publikováno v: Vaccine, 25(35), 6501-6510. Elsevier BV

Previously, we have shown the potency of recombinant Adenovirus serotype 35 viral vaccines (rAd35) to induce strong immune response against the circumsporozoite protein (CS) of the plasmodium parasite. To further optimize immunogenicity of Ad35-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f8ff63565ff5387d72985a5182a3b9
https://doi.org/10.1016/j.vaccine.2007.06.019

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Novel replication-incompetent adenoviral B-group vectors: high vector stability and yield in PER.C6 cells

Publikováno v: Journal of general virology, 87(Part 8), 2135-2143. Society for General Microbiology

Adenoviral vectors based on adenovirus type 35 (rAd35) have the advantage of low natural vector immunity and induce strong, insert-specific T- and B-cell responses, making them prime-candidate vaccine carriers. However, severe vector-genome instabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ab29129c85d052e2d58b210d898735
https://doi.org/10.1099/vir.0.81956-0

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Generation of a novel replication-incompetent adenoviral vector derived from human adenovirus type 49: manufacture on PER.C6 cells, tropism and immunogenicity

Autor: Ben Berkhout, Angelique A. C. Lemckert, Jos M. Grimbergen, Ronald Vogels, Paul H.A. Quax, Shirley Smits, Eric Hartkoorn, Dan H. Barouch, Lennart Holterman, Menzo J. E. Havenga, Jaap Goudsmit

Publikováno v: Journal of general virology, 87(10), 2891-2899. Society for General Microbiology

Recombinant adenoviral vectors based on type 5 (rAd5) show great promise as a vaccine carrier. However, neutralizing activity against Ad5 is prevalent and high-titred among human populations, and significantly dampens Ad5-based vaccine modalities. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8510507dad6bd2c859b47c982a0fd7a
https://doi.org/10.1099/vir.0.82079-0

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Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family

Autor: Timothy T. Stedman, Clemens H. M. Kocken, Alan W. Thomas, Sanjeev Krishna, Thierry Joët, Lennart Holterman, Annemarie van der Wel

Publikováno v: Biochemical Journal. 368:923-929

Chemotherapy of apicomplexan parasites is limited by emerging drug resistance or lack of novel targets. PfHT1, the Plasmodium falciparum hexose transporter 1, is a promising new drug target because asexual-stage malarial parasites depend wholly on gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b6413b3be588fffb3e359f68f04053
https://doi.org/10.1042/bj20021189

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Specific passage of simian immunodeficiency virus from end-stage disease results in accelerated progression to AIDS in rhesus macaques

Autor: Lennart Holterman, Jonathan L. Heeney, Jaap Goudsmit, Henk Niphuis, Peter ten Haaft, Gary B. Baskin

Publikováno v: Journal of general virology, 80(12), 3089-3097. Society for General Microbiology

To determine whether passage of late-stage variants of simian immunodeficiency virus (SIV) would lead to a more virulent infection and rapid disease progression, a study was designed to examine the effects of selective transmission of SIV from late-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b57743927db0dd896eb71535353495
https://doi.org/10.1099/0022-1317-80-12-3089

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