Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Lennart, Randau"'
Autor:
José Vicente Gomes-Filho, Ruth Breuer, Hector Gabriel Morales-Filloy, Nadiia Pozhydaieva, Andreas Borst, Nicole Paczia, Jörg Soppa, Katharina Höfer, Andres Jäschke, Lennart Randau
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract NAD is a coenzyme central to metabolism that also serves as a 5′-terminal cap for bacterial and eukaryotic transcripts. Thermal degradation of NAD can generate nicotinamide and ADP-ribose (ADPR). Here, we use LC-MS/MS and NAD captureSeq to
Externí odkaz:
https://doaj.org/article/b2bd0d8d07d04d60867ee100d9ab99d3
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Nudix hydrolases comprise a large and ubiquitous protein superfamily that catalyzes the hydrolysis of a nucleoside diphosphate linked to another moiety X (Nudix). Sulfolobus acidocaldarius possesses four Nudix domain-containing proteins (SACI_RS00730
Externí odkaz:
https://doaj.org/article/7d4ee431321741ecb332433e4d08db26
Autor:
Sherif Ismail, Dirk Flemming, Matthias Thoms, José Vicente Gomes-Filho, Lennart Randau, Roland Beckmann, Ed Hurt
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110640- (2022)
Summary: Synthesis of ribosomes begins in the nucleolus with formation of the 90S pre-ribosome, during which the pre-40S and pre-60S pathways diverge by pre-rRNA cleavage. However, it remains unclear how, after this uncoupling, the earliest pre-60S s
Externí odkaz:
https://doaj.org/article/27375245d6574290b05c0e5634e7188e
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Post-transcriptional modifications fulfill many important roles during ribosomal RNA maturation in all three domains of life. Ribose 2'-O-methylations constitute the most abundant chemical rRNA modification and are, for example, involved in RNA foldi
Externí odkaz:
https://doaj.org/article/e6b9f8b4a159400f810e3f0e870967ef
Autor:
Hanna Müller-Esparza, Manuel Osorio-Valeriano, Niklas Steube, Martin Thanbichler, Lennart Randau
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
CRISPR-Cas systems employ ribonucleoprotein complexes to identify nucleic acid targets with complementarity to bound CRISPR RNAs. Analyses of the high diversification of these effector complexes suggest that they can exhibit a wide spectrum of target
Externí odkaz:
https://doaj.org/article/2e3fb407e04e4be5833904ba74460ee7
Publikováno v:
BIOspektrum. 28:370-373
Class 1 CRISPR-Cas systems are prevalent among prokaryotes and are characterized by effector complexes that consist of multiple Cas protein subunits. Type I systems recruit the DNA nuclease Cas3 for target DNA degradation. Type IV systems exhibit CRI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9e4a4205c2f0332cff555e2947bae0
https://doi.org/10.1007/s12268-022-1775-9
https://doi.org/10.1007/s12268-022-1775-9
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT L7Ae is a universal archaeal protein that recognizes and stabilizes kink-turn (k-turn) motifs in RNA substrates. These structural motifs are widespread in nature and are found in many functional RNA species, including ribosomal RNAs. Synthet
Externí odkaz:
https://doaj.org/article/4e4ee348cfd74aa99185d8ed52239309
Publikováno v:
Nucleic Acids Research
Phages and other mobile genetic elements express anti-CRISPR proteins (Acrs) to protect their genomes from destruction by CRISPR–Cas systems. Acrs usually block the ability of CRISPR–Cas systems to bind or cleave their nucleic acid substrates. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d287a11e0cfcd18d18110b5b5dc66d6
https://doi.org/10.1093/nar/gkab092
https://doi.org/10.1093/nar/gkab092
Autor:
Xiaohan Guo, Mariana Sanchez-Londono, Vicente Gomes-Filho, Rogelio Hernández-Tamayo, Selina Rust, Leah Immelmann, Pascal Schäfer, Julia Wiegel, Peter Graumann, Lennart Randau
Many bacteria contain Class I CRISPR-Cas systems and utilize multi-subunit ribonucleoprotein complexes to interfere with mobile genetic elements. The activities of these complexes are described in detail for Type I effector complexes, showing CRISPR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3a28cd462c98a33ae8cfb895799473b
https://doi.org/10.21203/rs.3.rs-1138708/v1
https://doi.org/10.21203/rs.3.rs-1138708/v1
Autor:
Xiaohan Guo, Mariana Sanchez-Londono, José Vicente Gomes-Filho, Rogelio Hernandez-Tamayo, Selina Rust, Leah M. Immelmann, Pascal Schäfer, Julia Wiegel, Peter L. Graumann, Lennart Randau
Publikováno v:
Nature microbiology. 7(11)
Bacterial Type IV CRISPR-Cas systems are thought to rely on multi-subunit ribonucleoprotein complexes to interfere with mobile genetic elements, but the substrate requirements and potential DNA nuclease activities for many systems within this type ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5d9b3bf5dbd14fd64ec236af2c88f0
https://pubmed.ncbi.nlm.nih.gov/36175516
https://pubmed.ncbi.nlm.nih.gov/36175516