Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lenka Trilecová"'
Autor:
Miroslav Machala, Jan Vondráček, Jiří Neča, Jan Topinka, Kateřina Pěnčíková, Alena Milcova, Lenka Trilecová, Miroslav Ciganek, Lenka Pálková
Publikováno v:
Toxicology in Vitro. 29:438-448
Diesel exhaust particles (DEP) and the associated complex mixtures of organic pollutants, such as polycyclic aromatic hydrocarbons (PAHs), or their derivatives, have been suggested to exert deleterious effects on human health. We used a set of define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45598f047495300258600cd949aec575
https://doi.org/10.1016/j.tiv.2014.12.002
https://doi.org/10.1016/j.tiv.2014.12.002
Autor:
Pavel Krčmář, Jan Topinka, Alena Milcova, Zuzana Valovičová, Jan Vondráček, Miroslav Machala, Monika Mesárošová, Jana Schmuczerova, Eva Hrubá, Lenka Trilecová, Alena Gábelová, Soňa Marvanová
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 743:91-98
Differences between tissues in the expression of drug-metabolizing enzymes may substantially contribute to tissue-specificity of chemical carcinogens. To verify this hypothesis, the spontaneously immortalized human keratinocytes HaCaT were used, in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af036679680377c44981935a20baf75
https://doi.org/10.1016/j.mrgentox.2011.12.030
https://doi.org/10.1016/j.mrgentox.2011.12.030
Autor:
Soňa Marvanová, Alena Gábelová, Monika Mesárošová, Jan Topinka, Eva Hrubá, Jan Vondráček, Alena Milcova, Zuzana Valovičová, Lenka Trilecová, Miroslav Machala, Pavel Krčmárˇ, Jana Schmuczerova
Publikováno v:
Environmental and Molecular Mutagenesis. 52:636-645
The goal of this study was to investigate the genotoxicity of 7H-dibenzo[c,g]carbazole (DBC), a ubiquitous environmental pollutant, and its methyl derivatives, 5,9-dimethylDBC (DiMeDBC), a strict hepatocarcinogen, and N-methylDBC (N-MeDBC), a specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65013d09d384abd339663374dd635d72
https://doi.org/10.1002/em.20664
https://doi.org/10.1002/em.20664
Autor:
Barbora Szotáková, Alois Kozubík, Martina Gavelová, Lenka Skálová, Hana Radilova, Martin Bunček, Lenka Trilecová, Pavel Krcmar, Jan Vondráček, Miroslav Machala, Jirina Prochazkova
Publikováno v:
Chemico-Biological Interactions. 180:226-237
In contrast to hepatocytes, there is only limited information about the expression and activities of enzymes participating in metabolic activation of environmental mutagens, including polycyclic aromatic hydrocarbons (PAHs), in liver progenitor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f41050b027d3122f507db719a5d2601
https://doi.org/10.1016/j.cbi.2009.03.011
https://doi.org/10.1016/j.cbi.2009.03.011
Autor:
Alena Milcova, Miroslav Machala, Jan Vondráček, Pavel Krčmářř, Lenka Trilecová, Kateřřina Pěnččíková, Zuzana Novakova, Soňa Marvanová, Jan Topinka
Publikováno v:
Chemical Research in Toxicology. 21:503-512
Monomethylated benz[ a]anthracenes (MeBaAs) are an important group of methylated derivatives of polycyclic aromatic hydrocarbons (PAHs). Although the methyl substitution reportedly affects their mutagenicity and tumor-initiating activity, little is k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc6fc8ef75c4589e012f694624a6922
https://doi.org/10.1021/tx700305x
https://doi.org/10.1021/tx700305x
Autor:
Lenka Pálková, Simona Krčková, Soňa Marvanová, Jan Topinka, Miroslav Ciganek, Miroslav Machala, Jiří Neča, Jan Vondráček, Alena Milcova, Pavel Krčmář, Kateřina Pĕnčíková, Petra Hulinková, Lenka Trilecová
Publikováno v:
Chemical research in toxicology. 24(6)
The methylated benzo[a]pyrenes (MeBaPs) are present at significant levels in the environment, especially in the sediments contaminated by petrogenic PAHs. However, the existing data on their toxic effects in vitro and/or in vivo are still largely inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2437d03e430aa2dae3f18c4a5d8cd55d
https://pubmed.ncbi.nlm.nih.gov/21604763
https://pubmed.ncbi.nlm.nih.gov/21604763
Autor:
Veronika Hanušová, Věra Králová, Ladislava Schroterova, A Pakostová, Lenka Trilecová, Lenka Skálová
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 40(10)
The maximal therapeutic doses of the cytostatic drug doxorubicin (DOX) are strictly limited by the development of systemic toxicity, especially cardiotoxicity. The inhibition of DOX-metabolizing enzymes within cancer cells is possible strategy to imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e38678355c006d0a27cd7b29a09cc52
https://pubmed.ncbi.nlm.nih.gov/20698750
https://pubmed.ncbi.nlm.nih.gov/20698750
Autor:
Andrea Staršíchová, Pavel Krcmar, Lenka Vykopalova, Sona Marvanová, Miroslav Machala, Helena Libalova, Alena Milcova, Eva Hrubá, Jan Vondráček, Karel Souček, Jan Topinka, Lenka Trilecová
Publikováno v:
Toxicology letters. 197(3)
Exposure to polycyclic aromatic hydrocarbons (PAHs) has been positively associated with prostate cancer, but knowledge of the formation of PAH–DNA adducts and related genotoxic events in prostatic cells is limited. In the present study, benzo[ a ]p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c2c30b0e40451c637c427665f2e11c
https://pubmed.ncbi.nlm.nih.gov/20542099
https://pubmed.ncbi.nlm.nih.gov/20542099
Autor:
Jan Vondráček, Jan Topinka, Miroslav Machala, Sona Marvanová, Pavlína Šimečková, Helena Libalova, Eva Hrubá, Karel Souček, Lenka Trilecová, Lenka Vykopalova
Publikováno v:
Toxicology Letters. 180:S37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29c61533d94b51878f2c329de349fb3f
https://doi.org/10.1016/j.toxlet.2008.06.663
https://doi.org/10.1016/j.toxlet.2008.06.663
Autor:
Soňa Marvanová, Jan Vondráček, Kateřřina Pěnččíková, Lenka Trilecová, Pavel Krčmářř, Jan Topinka, Zuzana Nováková, Alena Milcová, Miroslav Machala
Publikováno v:
Chemical Research in Toxicology; Feb2008, Vol. 21 Issue 2, p503-512, 10p