Výsledky vyhledávání - "Lenka Sedláková"

Akademický článek

Increased Endogenous Activity of the Renin-Angiotensin System Reduces Infarct Size in the Rats with Early Angiotensin II-dependent Hypertension which Survive the Acute Ischemia/Reperfusion Injury

Autor: Zuzana Husková, Soňa Kikerlová, Janusz Sadowski, Petra Alánová, Lenka Sedláková, František Papoušek, Jan Neckář

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

We investigated the role of the interaction between hypertension and the renin-angiotensin system in the pathophysiology of myocardial ischemia/reperfusion injury. We hypothesized that in the early phase of angiotensin II (ANG II)-dependent hypertens

Externí odkaz: https://doaj.org/article/5ab8a24d04914344942d166753e4185b

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Akademický článek

Renin–angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats

Autor: Lenka Sedláková, Věra Čertíková Chábová, Šárka Doleželová, Petra Škaroupková, Libor Kopkan, Zuzana Husková, Lenka Červenková, Soňa Kikerlová, Ivana Vaněčková, Janusz Sadowski, Elzbieta Kompanowska-Jezierska, Petr Kujal, Herbert J. Kramer, Luděk Červenka

Publikováno v: Clinical and Experimental Hypertension, Vol 39, Iss 2, Pp 183-195 (2017)

Background: Early addition of endothelin (ET) type A (ETA) receptor blockade to complex renin–angiotensin system (RAS) blockade has previously been shown to provide better renoprotection against progression of chronic kidney disease (CKD) in Ren-2

Externí odkaz: https://doaj.org/article/069801b85c634eb1ad2d34b86397326b

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Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats

Autor: František Kolář, Šárka Škutová, Abdul H. Khan, Lenka Sedláková, John R. Falck, David Sedmera, Jaroslav Hrdlička, Veronika Olejnickova, William B. Campbell, Garrett J. Gross, Michaela Cyprová, Alena Kvasilova, Jan Neckář, John D. Imig, Martina Gregorovicova

Publikováno v: Clinical science (London, England : 1979)

Epoxyeicosatrienoic acids (EETs) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3affb38b56533461d73cb4f96c0aa61f
https://doi.org/10.1042/cs20180728

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The effect of different physical forms of starter feed on rumen fermentation indicators and weight gain in calves after weaning

Autor: Lenka Sedláková, Leoš Pavlata, Petr Doležal, Ondřej Šťastník, Hana Dočkalová, Eva Mrkvicová, Štěpánka Křivová

Publikováno v: Acta Veterinaria Brno, Vol 86, Iss 3, Pp 285-291 (2017)

The aim of the study was to determine the effect of different physical forms of starter feed on rumen fermentation indicators of calves after weaning and their weight gain. The experiment was performed with Czech Fleckvieh calves after weaning. The c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1c62448cd7eb51a10e34bad89a6a61
https://doi.org/10.2754/avb201786030285

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Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension

Autor: Soňa Kikerlová, Petra Alánová, Janusz Sadowski, Sung H. Hwang, Elzbieta Kompanowska-Jezierska, Jan Neckář, John R. Falck, John D. Imig, Libor Kopkan, Luděk Červenka, František Kolář, Zdenka Vaňourková, Lenka Sedláková, Bruce D. Hammock, Zuzana Husková

Publikováno v: Journal of hypertension, vol 36, iss 6
J Hypertens

OBJECTIVE: We examined the effects of treatment with soluble epoxide hydrolase inhibitor (sEHi) and epoxyeicosatrienoic acids (EETs) analogue (EET-A), given alone or combined, on blood pressure (BP) and ischemia/reperfusion myocardial injury in rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c429969fe7719e792f109bfdad8962
https://escholarship.org/uc/item/8hj1j00t

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The exaggerated salt-sensitive response in hypertensive transgenic rats (TGR mRen-2) fostered by a normotensive female

Autor: Soňa Kikerlová, Lenka Červenková, Hana Sutovska, Libor Kopkan, Šárka Vacková, Zuzana Husková, Zdenka Vaňourková, Lenka Sedláková, Michal Zeman, Pavel Svitok

Publikováno v: Hypertension research : official journal of the Japanese Society of Hypertension. 42(4)

Suboptimal conditions during prenatal and early postnatal development can increase risk of hypertension later in life. We studied consequences of a changed perinatal environment by initiating the cross-fostering of homozygous Ren-2 transgenic rat (TG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53168822edb14c621815811e870650a2
https://pubmed.ncbi.nlm.nih.gov/30531845

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