Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lenka Markova"'
Autor:
Monika Hreusova, Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Ivan Potočňák, Viktor Brabec, Jana Kasparkova
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2022 (2022)
In this work, gallium(III) complex with cloxyquin (5-chloro-8-quinolinol, HClQ) ligands is shown to effectively inhibit proliferation of rhabdomyosarcoma cells, the frequent, aggressive, and poorly treatable cancer of children. It offers striking sel
Externí odkaz:
https://doaj.org/article/9c53d497024647a2992bcd5d8fe8e554
Autor:
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Аlexey A. Logvinov, Viktor V. Temnov, Nataliya E. Borisova, Tatiana A. Podrugina, Lenka Markova, Pavel Starha, Alexey. A. Nazarov, Viktor Brabec
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2022 (2022)
One concept of improving anticancer effects of conventional platinum-based antitumor drugs consists of conjugating these compounds with other biologically (antitumor) active agents, acting by a different mechanism. Here, we present synthesis, physico
Externí odkaz:
https://doaj.org/article/3ca46adcbf094b3faac19d8bb49e9a33
Autor:
Sarka Jelinkova, Lenka Markova, Martin Pesl, Iveta Valáškova, Eva Makaturová, Lenka Jurikova, Petr Vondracek, Alain Lacampagne, Petr Dvorak, Albano C. Meli, Vladimir Rotrekl
Publikováno v:
Stem Cell Research, Vol 40, Iss , Pp - (2019)
Duchenne muscular dystrophy (DMD) affects 1:3500–5000 newborn boys and manifests with progressive skeletal muscle wasting, respiratory failure and eventual heart failure. Symptoms show different onset from patients' childhood to the second decade o
Externí odkaz:
https://doaj.org/article/cdd3609ab2de48e98c2cf4a95cd1e333
Autor:
Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Marie Svitelova, Jana Kasparkova, Alessandra Barbanente, Paride Papadia, Nicola Margiotta, James D. Hoeschele, Viktor Brabec
Publikováno v:
Inorganic Chemistry Frontiers. 9:3295-3305
Here, we investigated the mechanism of antiproliferative action in cancer cells of new compounds structurally derived from oxaliplatin, namely a pair of enantiomers [Pt(OXA)(1R,2R-DACHEX)] (1) and [Pt(OXA)(1S,2S-DACHEX)] (2) (OXA = oxalate, DACHEX =
Autor:
Viktor Brabec, Natalia Cutillas, Hana Kostrhunova, Jana Kasparkova, Vojtech Novohradsky, José Ruiz, Gloria Vigueras, Alicia Marco, Lenka Markova
Publikováno v:
Inorganic Chemistry Frontiers. 8:4696-4711
Several anticancer chemotherapies, while eliminating the bulk of tumor cells, often fail, as they do not obliterate a small fraction of malignant cancer stem cells (CSCs). Thus, developing chemotherapeutics capable of targeting and abrogating CSCs, i
Publikováno v:
Angewandte Chemie International Edition. 59:21157-21162
HER2-positive breast cancer is an aggressive subtype that typically responds poorly to standard chemotherapy. To design an anticancer drug selective for HER2-expressing breast cancer, a PtIV prodrug with axial oleate and cinnamate ligands was synthes
Autor:
Jakub Cervinka, Alberto Gobbo, Lorenzo Biancalana, Lenka Markova, Vojtech Novohradsky, Massimo Guelfi, Stefano Zacchini, Jana Kasparkova, Viktor Brabec, Fabio Marchetti
While ruthenium arene complexes have been widely investigated for their medicinal potential, studies on homologous compounds containing a tridentate tris(1-pyrazolyl)methane ligand are almost absent in the literature. Ruthenium(II) complex 1 was obta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd17dcb4f17b7dfa42b651c08e935e6
https://hdl.handle.net/11585/897692
https://hdl.handle.net/11585/897692
Autor:
Alba Hernández-García, Lenka Markova, María Dolores Santana, Jitka Pracharova, Viktor Brabec, José Ruiz, Jana Kasparkova
Publikováno v:
SSRN Electronic Journal.
Autor:
Monika Hreusova, Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Ivan Potočňák, Viktor Brabec, Jana Kasparkova
Publikováno v:
Bioinorganic chemistry and applications. 2022
In this work, gallium(III) complex with cloxyquin (5-chloro-8-quinolinol, HClQ) ligands is shown to effectively inhibit proliferation of rhabdomyosarcoma cells, the frequent, aggressive, and poorly treatable cancer of children. It offers striking sel
Autor:
Vojtech, Novohradsky, Lenka, Markova, Hana, Kostrhunova, Jana, Kasparkova, James, Hoeschele, Viktor, Brabec
Publikováno v:
Journal of inorganic biochemistry. 226
The platinum drugs belong to prevailing chemotherapeutics used in the treatment of cancer. At present, however, the search for new anticancer metal-based drugs that operate by the mechanisms distinct from those of the conventional chemotherapeutics i