Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lenka Koudelková"'
Autor:
Lenka Koudelková, Markéta Pelantová, Zuzana Brůhová, Martin Sztacho, Vojtěch Pavlík, Dalibor Pánek, Jakub Gemperle, Pavel Talacko, Jan Brábek, Daniel Rösel
Publikováno v:
eLife, Vol 12 (2023)
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state. The tr
Externí odkaz:
https://doaj.org/article/3b1c7c87d3bb4e7db96521db2ea11862
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 264-289 (2019)
Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes.
Externí odkaz:
https://doaj.org/article/a8150fc97bc04d568eba1811cd1a86f5
Autor:
Lenka Koudelková, Zuzana Brůhová, Martin Sztacho, Vojtěch Pavlík, Dalibor Pánek, Jakub Gemperle, Jan Brábek, Daniel Rösel
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state. The tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8307b96f9c387523d586edb3269e8be4
https://doi.org/10.1101/2022.08.23.504940
https://doi.org/10.1101/2022.08.23.504940
Autor:
Lenka Koudelková, Daniel Rösel, Jakub Gemperle, Michal Dibus, Jan Brábek, Keziban Unsal-Kacmaz
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 264-289 (2019)
Gemperle, J, Dibus, M, Koudelkova, L, Rosel, D & Brabek, J 2019, ' The interaction of p130Cas with PKN3 promotes malignant growth ', Molecular Oncology, vol. 13, no. 2, pp. 264-289 . https://doi.org/10.1002/1878-0261.12401
Molecular Oncology
Gemperle, J, Dibus, M, Koudelkova, L, Rosel, D & Brabek, J 2019, ' The interaction of p130Cas with PKN3 promotes malignant growth ', Molecular Oncology, vol. 13, no. 2, pp. 264-289 . https://doi.org/10.1002/1878-0261.12401
Molecular Oncology
Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e162bd30a9b9601271224aed2e07a794
https://doaj.org/article/a8150fc97bc04d568eba1811cd1a86f5
https://doaj.org/article/a8150fc97bc04d568eba1811cd1a86f5
Publikováno v:
The international journal of biochemistrycell biology. 131
Cells have developed a unique set of molecular mechanisms that allows them to probe mechanical properties of the surrounding environment. These systems are based on deformable primary mechanosensors coupled to tension transmitting proteins and enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b47924afdf39c3eea86d96980ba71af
https://pubmed.ncbi.nlm.nih.gov/33359015
https://pubmed.ncbi.nlm.nih.gov/33359015
Autor:
Larisa M. Ryzhova, Daniel Rösel, Lenka Koudelková, Jan Brábek, Radoslav Janostiak, Steven K. Hanks, Ondřej Tolde, Weifeng Luo, Michal Dibus
The tyrosine kinase Src acts as a key regulator of cell motility by phosphorylating multiple protein substrates that control cytoskeletal and adhesion dynamics. In an earlier phosphotyrosine proteomics study, we identified a novel Rho-GTPase activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894a6a06d0aafe5b2167234eb0d3d1a1
https://europepmc.org/articles/PMC5536916/
https://europepmc.org/articles/PMC5536916/
Autor:
Daniel Rösel, Andreea Csilla Pataki, Kurt I. Anderson, Jan Brábek, Max Nobis, Jakub Gemperle, Lenka Koudelková, Ondřej Tolde, Vojtech Pavlik
Publikováno v:
Cell Chemical Biology. 26:255-268.e4
Src kinase plays an important role in a multitude of fundamental cellular processes and is often found deregulated in tumors. Active Src adopts an open conformation, whereas inactive Src is characterized by a very compact structure stabilized by inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fdf2f47ddc755ec18e60825e9c6c0e
https://doi.org/10.1016/j.chembiol.2018.10.024
https://doi.org/10.1016/j.chembiol.2018.10.024