Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lenka Hromadkova"'
Autor:
Lenka Hromadkova, Chae Kim, Tracy Haldiman, Lihua Peng, Xiongwei Zhu, Mark Cohen, Rohan de Silva, Jiri G. Safar
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-25 (2023)
Abstract Objectives Although accumulation of misfolded tau species has been shown to predict cognitive decline in patients with Alzheimer’s disease (AD) and other tauopathies but with the remarkable diversity of clinical manifestations, neuropathol
Externí odkaz:
https://doaj.org/article/1bf5a23fc0af4be6baee96c7e0437b3f
Publikováno v:
Cells, Vol 11, Iss 19, p 2997 (2022)
Recent findings of diverse populations of prion-like conformers of misfolded tau protein expand the prion concept to Alzheimer’s disease (AD) and monogenic frontotemporal lobar degeneration (FTLD)-MAPT P301L, and suggest that distinct strains of mi
Externí odkaz:
https://doaj.org/article/a987260a036d45a7ae2af6b07d5db184
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Tau accumulation is a prominent feature in a variety of neurodegenerative disorders and remarkable effort has been expended working out the biochemistry and cell biology of this cytoplasmic protein. Tau's wayward properties may derive from germline m
Externí odkaz:
https://doaj.org/article/90a29ee016fd4574ada8253ec57d50c6
Autor:
Sophia Schedin-Weiss, Mitsuhiro Inoue, Lenka Hromadkova, Yasuhiro Teranishi, Natsuko Goto Yamamoto, Birgitta Wiehager, Nenad Bogdanovic, Bengt Winblad, Anna Sandebring-Matton, Susanne Frykman, Lars O. Tjernberg
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-19 (2017)
Abstract Background Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its precursor by the transmembrane protease γ-secretase, are found in Alzheimer disease (AD) brains. Interestingly, monoamine oxidase B (MAO-B) activity i
Externí odkaz:
https://doaj.org/article/e013012247bd498c9c9baac88e3a9855
Autor:
Lenka Hromadkova, Saak Victor Ovsepian
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
In Alzheimer’s disease (AD), tau pathology manifested by the accumulation of intraneuronal tangles and soluble toxic oligomers emerges as a promising therapeutic target. Multiple anti-tau antibodies inhibiting the formation and propagation of cytot
Externí odkaz:
https://doaj.org/article/0e39cd4c7f1540bc9dc7be3a257cc175
Publikováno v:
Prions and Diseases ISBN: 9783031205644
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33c557bcf31bccb8fe07f461aaf03f43
https://doi.org/10.1007/978-3-031-20565-1_7
https://doi.org/10.1007/978-3-031-20565-1_7
Autor:
Jan Klaschka, Martin Vyhnalek, Tomáš Špringer, Jan Laczó, Jiri Homola, Ales Stuchlik, Adéla Hofmannova, Tomas Petrasek, Jakub Hort, Lenka Hromadkova, Zdenka Kristofikova, Erika Gedeonová, Jan Ricny, Karel Vales, Tomas Nikolai
Publikováno v:
Neurochemical Research
The nucleus-encoded 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) regulates cyclophilin D (cypD) in the mitochondrial matrix. CypD regulates opening of mitochondrial permeability transition pores. Both mechanisms may be affected by amyloid
Publikováno v:
Journal of Neuroimmunology. 313:16-24
The presence of natural tau-reactive antibodies was reported in human blood. In this study, we isolated and characterized natural tau-reactive antibodies occurring in IVIG product Flebogamma, plasma of patients with Alzheimer's disease (AD) and older
Autor:
Lenka Hromadkova, Dagmar Bezdekova, Saak V. Ovsepian, Jan Pala, Lars O. Tjernberg, Cyril Höschl, Sophia Schedin-Weiss
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1867(9)
Throughout development, neuronal progenitors undergo complex transformation into polarized nerve cells, warranting the directional flow of information in the neural grid. The majority of neuronal polarization studies have been carried out on rodent-d
Autor:
Saak V. Ovsepian, Lenka Hromadkova
Publikováno v:
Journal of Immunology Research
Journal of Immunology Research, Vol 2019 (2019)
Journal of Immunology Research, Vol 2019 (2019)
In Alzheimer’s disease (AD), tau pathology manifested in the accumulation of intraneuronal tangles and soluble toxic oligomers emerges as a potential therapeutic target. Multiple anti-tau antibodies inhibiting the formation and propagation of cytot