Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lenka Hernychova"'
Autor:
Iva Benesova, Rudolf Nenutil, Adam Urminsky, Erika Lattova, Lukas Uhrik, Peter Grell, Filip Zavadil Kokas, Jana Halamkova, Zbynek Zdrahal, Borivoj Vojtesek, Milos V. Novotny, Lenka Hernychova
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Breast cancer is a highly heterogeneous disease. Its intrinsic subtype classification for diagnosis and choice of therapy traditionally relies on the presence of characteristic receptors. Unfortunately, this classification is often not suffi
Externí odkaz:
https://doaj.org/article/94832c75874a4386884dac9683301066
Autor:
Michal Nemergut, Sérgio M. Marques, Lukas Uhrik, Tereza Vanova, Marketa Nezvedova, Darshak Chandulal Gadara, Durga Jha, Jan Tulis, Veronika Novakova, Joan Planas-Iglesias, Antonin Kunka, Anthony Legrand, Hana Hribkova, Veronika Pospisilova, Jiri Sedmik, Jan Raska, Zbynek Prokop, Jiri Damborsky, Dasa Bohaciakova, Zdenek Spacil, Lenka Hernychova, David Bednar, Martin Marek
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-25 (2023)
Abstract Background Apolipoprotein E (ApoE) ε4 genotype is the most prevalent risk factor for late-onset Alzheimer’s Disease (AD). Although ApoE4 differs from its non-pathological ApoE3 isoform only by the C112R mutation, the molecular mechanism o
Externí odkaz:
https://doaj.org/article/3de537d320b7425ab0b3c676809f76bd
Autor:
Małgorzata Lisowska, Fiona Lickiss, Maria Gil-Mir, Anne-Sophie Huart, Zuzanna Trybala, Luke Way, Lenka Hernychova, Adam Krejci, Petr Muller, Radovan Krejcir, Igor Zhukow, Przemyslaw Jurczak, Sylwia Rodziewicz-Motowidło, Kathryn Ball, Borivoj Vojtesek, Ted Hupp, Umesh Kalathiya
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Defining dynamic protein–protein interactions in the ubiquitin conjugation reaction is a challenging research area. Generating peptide aptamers that target components such as ubiquitin itself, E1, E2, or E3 could provide tools to dissect novel feat
Externí odkaz:
https://doaj.org/article/50c9ca635a8b45c68a43022c66190cbb
Autor:
Andrea Schenkmayerova, Gaspar P. Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T. Bornscheuer, Jiri Damborsky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Directed evolution commonly relies on point mutations but InDels frequently occur in evolution. Here the authors report a protein-engineering framework based on InDel mutagenesis and fragment transplantation resulting in greater catalysis and longer
Externí odkaz:
https://doaj.org/article/3c18b7a5373d42f0b49ea5eb1b1dcbad
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101247- (2022)
Summary: The neuroprotective E3-ubiquitin ligase CHIP is linked to healthy aging. Here, we present a protocol using a patient-derived iPSC line with a triplication of the α-synuclein gene to produce gene-edited cells isogenic for CHIP. We describe i
Externí odkaz:
https://doaj.org/article/9a6047e2764240678c08947604e8d494
Autor:
Catarina Dias, Erisa Nita, Jakub Faktor, Ailish C. Tynan, Lenka Hernychova, Borivoj Vojtesek, Jesper Nylandsted, Ted R. Hupp, Tilo Kunath, Kathryn L. Ball
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103921- (2022)
Externí odkaz:
https://doaj.org/article/184f2fb85b014d7dbde811a7e9b3a77b
Autor:
Ruidong Li, Pavlina Zatloukalova, Petr Muller, Maria Gil-Mir, Sachin Kote, Simon Wilkinson, Alain J. Kemp, Lenka Hernychova, Yaxin Wang, Kathryn L. Ball, Kaixiong Tao, Ted Hupp, Borivoj Vojtesek
Publikováno v:
Cellular & Molecular Biology Letters, Vol 25, Iss 1, Pp 1-21 (2020)
Abstract Background The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in the expression of two
Externí odkaz:
https://doaj.org/article/b8f9b11009b24fcab0d358372577dfdf
Autor:
Catarina Dias, Erisa Nita, Jakub Faktor, Ailish C. Tynan, Lenka Hernychova, Borivoj Vojtesek, Jesper Nylandsted, Ted R. Hupp, Tilo Kunath, Kathryn L. Ball
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102878- (2021)
Summary: CHIP is an E3-ubiquitin ligase that contributes to healthy aging and has been characterized as neuroprotective. To elucidate dominant CHIP-dependent changes in protein steady-state levels in a patient-derived human neuronal model, CHIP funct
Externí odkaz:
https://doaj.org/article/01017be915b44be0856d83d5615cd1e0
Autor:
Maria Gómez-Herranz, Jakub Faktor, Marcos Yébenes Mayordomo, Magdalena Pilch, Marta Nekulova, Lenka Hernychova, Kathryn L. Ball, Borivoj Vojtesek, Ted R. Hupp, Sachin Kote
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1090 (2022)
The IFITM restriction factors play a role in cancer cell progression through undefined mechanisms. We investigate new protein–protein interactions for IFITM1/3 in the context of cancer that would shed some light on how IFITM1/3 attenuate the expres
Externí odkaz:
https://doaj.org/article/f6ccedfb34244f7587bb5ef5265a4bb5
Autor:
Martin Stojaspal, Tomas Brom, Tomas Janovic, Ivona Necasova, Pavel Veverka, Lukas Uhrik, Lenka Hernychova, Ctirad Hofr
Congenital dyserythropoietic anemia type I (CDA-I) is a rare hereditary disease characterized by ineffective erythropoiesis and associated mutations in two proteins - Codanin1 and CDIN1. The primary role of Codanin1 is nucleosome assembly regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f9c1c90059bc1e76a3a0ab1307d3f2
https://doi.org/10.1101/2023.05.25.542057
https://doi.org/10.1101/2023.05.25.542057
