Potentiation of Anticancer Drugs: Effects of Pentoxifylline on Neoplastic Cells

Autor: Viera Bohacova, Albert Breier, Jan Sedlak, Zdena Sulova, Lenka Gibalová, Miroslav Barancik

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 13; Issue 1; Pages: 369-382
International Journal of Molecular Sciences, Vol 13, Iss 1, Pp 369-382 (2011)

The drug efflux activity of P-glycoprotein (P-gp, a product of the mdr1 gene, ABCB1 member of ABC transporter family) represents a mechanism by which tumor cells escape death induced by chemotherapeutics. In this study, we investigated the mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a4a84668d2bd0b6cca97d07533080c
https://doi.org/10.3390/ijms13010369

Expression of P-glycoprotein in L1210 cells is linked with rise in sensitivity to Ca2+

Autor: Uhrík B, Jozef Orlický, Mário Šereš, Roderik Fiala, Lenka Gibalová, Albert Breier, Zdena Sulova, Ima Dovinova

Publikováno v: Biochemical and Biophysical Research Communications. 335:777-784

L1210/VCR cell line (R) was obtained by adaptation of the L1210 mouse leukaemia cells (S) to vincristine and showed P-glycoprotein (P-gp) mediated multidrug resistance (MDR). R cells were observed to be more sensitive to high external calcium as pare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2553a04b37cedf4908ff861c6cdacf87
https://doi.org/10.1016/j.bbrc.2005.07.144

New insight into p-glycoprotein as a drug target

Autor: Zdenka Sulová, Albert Breier, Miroslav Barancik, Lenka Gibalová, Mário Šereš

Publikováno v: Anti-cancer agents in medicinal chemistry. 13(1)

Multidrug resistance (MDR) of cancer tissue is a phenomenon in which cancer cells exhibit reduced sensitivity to a large group of unrelated drugs with different mechanisms of pharmacological activity. Mechanisms that reduce cell sensitivity to damage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17a4550c83e618f084adb073d587f8f
https://pubmed.ncbi.nlm.nih.gov/22931413

The presence of P-glycoprotein in L1210 cells directly induces down-regulation of cell surface saccharide targets of concanavalin A

Autor: Zdena, Sulová, Peter, Ditte, Tatiana, Kurucová, Eva, Poláková, Kristína, Rogozanová, Lenka, Gibalová, Mário, Seres, Lucia, Skvarková, Ján, Sedlák, Jaromír, Pastorek, Albert, Breier

Publikováno v: Anticancer research. 30(9)

Overexpression of P-glycoprotein (P-gp), a plasma membrane drug transporter (ABCB1, a member of the ABC transporter family), is the most prevalent cause of multidrug resistance in cancer tissues. Lectin concanavalin A (ConA) induces massive cell deat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a5aafd5369fa50bf9943a9f2696629e
https://pubmed.ncbi.nlm.nih.gov/20944151

Vincristine-induced overexpression of P-glycoprotein in L1210 cells is associated with remodeling of cell surface saccharides

Autor: Uhrík B, Jan Sedlak, Annamária Kovárová, Zuzana Vajčnerová, Eva Poláková, Albert Breier, Danica Mislovičová, Lenka Gibalová, Zdenka Sulová, Lucia Tylková

Publikováno v: Journal of proteome research. 8(2)

Multidrug resistance of murine leukemic cell line L1210/VCR (R), obtained by adaptation of parental L1210 cells (S) on vincristine, is associated with overexpression of P glycoprotein (P-gp, the ATP-dependent drug efflux pump). Previously, we found t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eb04e0e0f9097455d717060d3741b4
https://pubmed.ncbi.nlm.nih.gov/19099507