Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction

Autor: Valeriia D. Andreeva, Haley Ehlers, Aswin Krishna R. C., Martin Presselt, Lenie J. van den Broek, Sylvestre Bonnet

Publikováno v: Communications Chemistry, Vol 6, Iss 1, Pp 1-22 (2023)

Abstract Cardiovascular diseases are the leading cause of death worldwide and are not typically diagnosed until the disease has manifested. Endothelial dysfunction is an early, reversible precursor in the irreversible development of cardiovascular di

Externí odkaz: https://doaj.org/article/c39cb87c74a841eaa236391ffca88dd7

Skin substitutes are more potent than dermal or epidermal substitutes in stimulating endothelial cell sprouting

Autor: Hanneke N. Monsuur, Ester M. Weijers, Susan Gibbs, Lenie J. van den Broek

Publikováno v: BMC Biomedical Engineering, Vol 1, Iss 1, Pp 1-7 (2019)

Abstract Background Therapy resistant ulcers are wounds that remain open for a long time period and often arise from chronic venous disease, prolonged pressure or diabetes. For healing of chronic wounds, revitalization of the inert wound bed, which i

Externí odkaz: https://doaj.org/article/ff0508988dc44f8885c187489a4de96a

A Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease

Autor: Luuk de Haan, Johnny Suijker, Ruthger van Roey, Nina Berges, Elissaveta Petrova, Karla Queiroz, Wouter Strijker, Thomas Olivier, Oliver Poeschke, Sakshi Garg, Lenie J. van den Broek

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 15, p 8234 (2021)

The recruitment of T cells is a crucial component in the inflammatory cascade of the body. The process involves the transport of T cells through the vascular system and their stable arrest to vessel walls at the site of inflammation, followed by extr

Externí odkaz: https://doaj.org/article/e18822e027634a1a969a3ade896b9357

Supplementary Figures 1-5 from Targeted Radiosensitization of Cells Expressing Truncated DNA Polymerase β

Autor: Conchita Vens, Adrian C. Begg, Lenie J. van den Broek, Manon Verwijs-Janssen, Sari Neijenhuis

Supplementary Figures 1-5 from Targeted Radiosensitization of Cells Expressing Truncated DNA Polymerase β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09aeb53390f64d1aed9d753594786490
https://doi.org/10.1158/0008-5472.22386881

Proof-of-Concept Organ-on-Chip Study:Topical Cinnamaldehyde Exposure of Reconstructed Human Skin with Integrated Neopapillae Cultured under Dynamic Flow

Autor: Irit Vahav, Maria Thon, Lenie J. van den Broek, Sander W. Spiekstra, Beren Atac, Gerd Lindner, Katharina Schimek, Uwe Marx, Susan Gibbs

Publikováno v: Vahav, I, Thon, M, van den Broek, L J, Spiekstra, S W, Atac, B, Lindner, G, Schimek, K, Marx, U & Gibbs, S 2022, ' Proof-of-Concept Organ-on-Chip Study : Topical Cinnamaldehyde Exposure of Reconstructed Human Skin with Integrated Neopapillae Cultured under Dynamic Flow ', Pharmaceutics, vol. 14, no. 8, 1529 . https://doi.org/10.3390/pharmaceutics14081529
Pharmaceutics; Volume 14; Issue 8; Pages: 1529
Vahav, I, Thon, M, van den Broek, L J, Spiekstra, S W, Atac, B, Lindner, G, Schimek, K, Marx, U & Gibbs, S 2022, ' Proof-of-Concept Organ-on-Chip Study : Topical Cinnamaldehyde Exposure of Reconstructed Human Skin with Integrated Neopapillae Cultured under Dynamic Flow ', Pharmaceutics, vol. 14, no. 8, 1529, pp. 1-16 . https://doi.org/10.3390/pharmaceutics14081529
Pharmaceutics, 14(8):1529. MDPI Multidisciplinary Digital Publishing Institute
Pharmaceutics, 14(8):1529, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)

Pharmaceutical and personal care industries require human representative models for testing to ensure the safety of their products. A major route of penetration into our body after substance exposure is via the skin. Our aim was to generate robust cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a762c54fe19cbad354276e7126afaa
https://research.vumc.nl/en/publications/84a66744-3055-42c6-a277-64587f41b155