Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Leni van Doorn"'
Autor:
Nikki S. IJzerman, Wills F. Filipe, Peter de Bruijn, Florian E. Buisman, Leni van Doorn, Pascal G. Doornebosch, Jessica J. Holster, Cecile Grootscholten, Dirk J. Grünhagen, Christian P.E. van Bommel, Marjolein Y.V. Homs, Niels F.M. Kok, Cornelis Verhoef, Bas Groot Koerkamp, Koert F.D. Kuhlmann, Ron H.J. Mathijssen, Stijn L.W. Koolen
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114625- (2023)
Background: Floxuridine’s high hepatic extraction ratio and short elimination half-life allows maximum liver exposure with minimal systemic side-effects. This study attempts to quantify the systemic exposure of floxuridine. Methods: Patients underg
Externí odkaz:
https://doaj.org/article/56549eb131c04a128fbca3d683e0aa28
Autor:
Mirjam de With, Leni van Doorn, Demi C. Maasland, Tessa A.M. Mulder, Esther Oomen-de Hoop, Bianca Mostert, Marjolein Y.V. Homs, Samira El Bouazzaoui, Ron H.J. Mathijssen, Ron H.N. van Schaik, Sander Bins
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114232- (2023)
Aim of the study: Occurrence of hand-foot syndrome (HFS) during capecitabine treatment often results in treatment interruptions (26 %) or treatment discontinuation (17 %), and can severely decrease quality of life. In this study, we investigated whet
Externí odkaz:
https://doaj.org/article/22d712ca5f2d4b6f9d5ea8fc0cd5da1f
Autor:
Niels A.D. Guchelaar, Ruben A.G. van Eerden, Stefanie L. Groenland, Leni van Doorn, Ingrid M.E. Desar, Ferry A.L.M. Eskens, Neeltje Steeghs, Nielka P. van Erp, Alwin D.R. Huitema, Ron H.J. Mathijssen, Stijn L.W. Koolen
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113393- (2022)
Introduction: Sorafenib is a tyrosine-kinase inhibitor approved for the treatment of renal cell carcinoma, hepatocellular carcinoma, thyroid carcinoma, and desmoid fibromatosis. As high inter-individual variability exists in exposure, there is a scie
Externí odkaz:
https://doaj.org/article/c31ed120337d415596ddbde434789268
Autor:
Charlène J. van der Zijden, Ben M. Eyck, Ate van der Gaast, Leni van Doorn, Joost J.M.E. Nuyttens, J. Jan B. van Lanschot, Bas P.L. Wijnhoven, Bianca Mostert, Sjoerd M. Lagarde
Publikováno v:
Contemporary Clinical Trials Communications, Vol 28, Iss , Pp 100934- (2022)
Background: FLOT and CROSS are effective neoadjuvant regimens for esophageal cancer patients. Chemotherapy (FLOT) is aimed to have merely a systemic effect whereas neoadjuvant chemoradiotherapy (CROSS) achieves good locoregional response with clinica
Externí odkaz:
https://doaj.org/article/11f5bfb8ec2d439a884eaa7e0d55bd6e
Autor:
Ruben A. G. van Eerden, Leni van Doorn, Femke M. de Man, Niels Heersche, Michail Doukas, Thierry P. P. van den Bosch, Esther Oomen-de Hoop, Peter de Bruijn, Sander Bins, Eman Ibrahim, Suzan Nikkessen, Lena E. Friberg, Stijn L. W. Koolen, Manon C. W. Spaander, Ron H. J. Mathijssen
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Data from previous work suggests that there is no correlation between systemic (plasma) paclitaxel exposure and efficacy in patients treated for esophageal cancer. In this trial, we investigated ATP-binding cassette efflux transporter exp
Externí odkaz:
https://doaj.org/article/2da8bb17075a4bb7a21f579be94bb87f
Autor:
Leni van Doorn, Mandy M. van Rosmalen, Wendy M. van der Deure, Esther Oomen-de Hoop, Robert Porrazzo, Sophie M. Wijngaard, Ingrid A. Boere, Paola Veenstra, Eman Ibrahim, Peter de Bruijn, Lena E. Friberg, Stijn L. W. Koolen, Ron H. J. Mathijssen, Agnes Jager
Publikováno v:
Cancers, Vol 13, Iss 15, p 3915 (2021)
Chemotherapy-induced alopecia (CIA), a side effect with high impact, can be prevented by cooling the scalp during the administration of some cytotoxic drugs. However, the effects of this prolonged scalp cooling on the pharmacokinetics of chemotherapy
Externí odkaz:
https://doaj.org/article/614a1a0671f746f2b22b173b61731ad0
Autor:
Koen G. A. M. Hussaarts, Leni van Doorn, Sander Bins, Dave Sprengers, Peter de Bruijn, Roelof W. F. van Leeuwen, Stijn L. W. Koolen, Teun van Gelder, Ron H. J. Mathijssen
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1, p 46 (2021)
Hepatocellular carcinoma (HCC) recurrence after liver transplantation occurs in approximately 20% of patients. Most of these patients use immunosuppressant drugs. Meanwhile, patients with HCC recurrence are frequently treated with the small molecule
Externí odkaz:
https://doaj.org/article/82d6a47b0b4a48389102ab8874b74d93
Autor:
Leni van Doorn, Marie-Rose B. S. Crombag, Hánah N. Rier, Jeroen L. A. van Vugt, Charlotte van Kesteren, Sander Bins, Ron H. J. Mathijssen, Mark-David Levin, Stijn L. W. Koolen
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1, p 47 (2021)
Changes in body composition are associated with chemotherapy-related toxicities and effectiveness of treatment. It is hypothesized that the pharmacokinetics (PK) of chemotherapeutics may depend on body composition. The effects of body composition on
Externí odkaz:
https://doaj.org/article/44294eeb4ea947efa337cb15104e1388
Autor:
Koen G. A. M. Hussaarts, Leni van Doorn, Karel Eechoute, Jeffrey Damman, Qiang Fu, Nadia van Doorn, Eric D. Eisenmann, Alice A. Gibson, Esther Oomen-de Hoop, Peter de Bruijn, Sharyn D. Baker, Stijn L. W. Koolen, Teun van Gelder, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen, Alex Sparreboom, Sander Bins
Publikováno v:
Pharmaceutics, Vol 12, Iss 9, p 788 (2020)
Prior studies have demonstrated an organic anion transporter 6 (OAT6)-mediated accumulation of sorafenib in keratinocytes. The OAT6 inhibitor probenecid decreases sorafenib uptake in skin and might, therefore, decrease sorafenib-induced cutaneous adv
Externí odkaz:
https://doaj.org/article/69e6321bc030407588a58b71ba48089f
Autor:
Femke M. de Man, Ruben A.G. van Eerden, Esther Oomen-de Hoop, Joris N. Veraart, Nadia van Doorn, Leni van Doorn, Ate van der Gaast, Ron H.J. Mathijssen
Publikováno v:
Cancers, Vol 11, Iss 6, p 826 (2019)
Many patients have advanced esophageal cancer at diagnosis. However, the most optimal treatment has not been identified. Therefore, we evaluated a weekly regimen of carboplatin (area under the curve (AUC)) of 4 and paclitaxel at 100 mg/m2 as an induc
Externí odkaz:
https://doaj.org/article/74f1a1336d6d4a2a8085068586f0ea82