Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lenguyen Huynh"'
Autor:
Steven M. Devine, Zhiliang Xie, Zhongfa Liu, William Blum, Cheryl Kefauver, Michael R. Grever, Kenneth K. Chan, Lenguyen Huynh, Rebecca B. Klisovic, James A. Zwiebel, Guido Marcucci, John C. Byrd
Publikováno v:
Leukemia & Lymphoma. 55:1332-1336
We hypothesized that GTI-2040, a 20-mer oligonucleotide complementary to the R2 subunit mRNA of ribonucleotide reductase, combined with high dose cytarabine (HiDAC) would result in enhanced cytotoxicity by favoring Ara-CTP DNA incorporation. In a pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2540a680cd8a820cdaa82291ed3a6a9
https://doi.org/10.3109/10428194.2013.838764
https://doi.org/10.3109/10428194.2013.838764
Autor:
Ryan Cottrell, Mette Prætorius-Ibba, Muthusamy Thangavel, Timothy Chen, Joy Maria Mitchell, Lenguyen Huynh
Publikováno v:
Cell Cycle. 9:3184-3190
Cells respond to nutrient deprivation a variety of ways. In addition to global downregulation of cap-dependent protein synthesis mediated by the GCN2 and mTORC1 signaling pathways, a catabolic process autophagy is upregulated to provide internal buil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bfc6d60c6a16b31fb2a23bd3c3beff2
https://doi.org/10.4161/cc.9.15.12525
https://doi.org/10.4161/cc.9.15.12525
Autor:
Guido Marcucci, Lenguyen Huynh, Zhiliang Xie, Jiuxia Pang, Rebecca B. Klisovic, John C. Byrd, Cheryl Kefauver, William Blum, Shujun Liu, Zhongfa Liu, Tamara Vukosavljevic, Michael R. Grever, James A. Zwiebel, Kenneth Chan, Steven M. Devine, Xiaohui Wei
Publikováno v:
Clinical Cancer Research. 14:3889-3895
Purpose: Inhibition of ribonucleotide reductase reduces the availability of the endogenous pool of deoxycytidine and may increase cytarabine (AraC) cytotoxicity. We performed a phase I dose escalation trial of AraC combined with GTI-2040, a 20-mer an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90acdf106a03b931c3688c950787074c
https://doi.org/10.1158/1078-0432.ccr-08-0109
https://doi.org/10.1158/1078-0432.ccr-08-0109
Autor:
Rebecca B. Klisovic, Lai-Chu Wu, Lenguyen Huynh, Tamara Vukosavljevic, Ramiro Garzon, Guido Marcucci, Kenneth Chan, William Blum, Esther B. Lehmann, Jianhua Yu, Michael A. Caligiuri, Pierluigi Porcu, Jiuxia Pang, Robert A. Baiocchi, Zhongfa Liu, Shujun Liu, Zhiliang Xie, Danilo Perrotti, John C. Byrd, Mitsui Takeki
Publikováno v:
Blood. 111:2364-2373
Bortezomib reversibly inhibits 26S proteasomal degradation, interferes with NF-kappaB, and exhibits antitumor activity in human malignancies. Zinc finger protein Sp1 transactivates DNMT1 gene in mice and is functionally regulated through protein abun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1468857cd4d163481a80e135f53ca6a
https://doi.org/10.1182/blood-2007-08-110171
https://doi.org/10.1182/blood-2007-08-110171
Autor:
Zhongfa Liu, Jianhua Yu, Rebecca B. Klisovic, Tamara Vukosavljevic, Peter Paschka, Danilo Perrotti, William Blum, Paolo Neviani, Kenneth K. Chan, Lenguyen Huynh, Guido Marcucci, Jiuxia Pang, Shujun Liu
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:953-960
In t(8;21) acute myeloid leukemia (AML), the AML1/ETO fusion protein promotes leukemogenesis by recruiting class I histone deacetylase (HDAC)-containing repressor complex to the promoter of AML1 target genes. Valproic acid (VPA), a commonly used anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7422821c998d826df05b49cdd11d88a3
https://doi.org/10.1124/jpet.106.118406
https://doi.org/10.1124/jpet.106.118406
Autor:
Carl Quinion, Emilia Mahoney, Lapo Alinari, Lenguyen Huynh, Rajeswaran Mani, Christian T. Earl, William H. Towns, Robert A. Baiocchi, Mette Prætorius-Ibba, Kristie A. Blum, David M. Goldenberg, Ching-Shih Chen, Yicheng Mao, John T. Patton, Natarajan Muthusamy, Bo Yu, Xiaoli Zhang, John C. Byrd
Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy with a short median survival despite multimodal therapy. FTY720, an immunosuppressive drug approved for the treatment of multiple sclerosis, promotes MCL cell death concurrent with down-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a1c88c81c88987a9f5fb3dcf9b6678
https://europepmc.org/articles/PMC3568700/
https://europepmc.org/articles/PMC3568700/
Autor:
Lenguyen Huynh, Sharon Golan, Jiuxia Pang, Bo Yu, Yeshayahu Talmon, Natarajan Muthusamy, Chee Guan Koh, Shujun Liu, Xiaojuan Yang, John C. Byrd, Yan Jin, Jintao Yang, Guido Marcucci, Robert J. Lee, L. James Lee, Kenneth K. Chan
Publikováno v:
Molecular pharmaceutics. 7(1)
Therapeutic use of oligodeoxynucleotides (ODNs) that hybridize to and downregulate target mRNAs encoding proteins that contribute to malignant transformation has a sound rationale, but has had an overall limited clinical success in cancer due to insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246815e49839f65ebd303eacd4238575
https://pubmed.ncbi.nlm.nih.gov/19852511
https://pubmed.ncbi.nlm.nih.gov/19852511
Autor:
Rebecca B. Klisovic, Steven M. Devine, Tamara Vukosavljevic, Christoph Plass, Cheryl Kefauver, Kenneth K. Chan, John C. Byrd, Zhongfa Liu, Gerard Lozanski, Anthony Murgo, Lenguyen Huynh, Nyla A. Heerema, Hollie Devine, Bjoern Hackanson, Michael R. Grever, Guido Marcucci, William Blum, Shujun Liu
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 25(25)
Purpose To determine an optimal biologic dose (OBD) of decitabine as a single agent and then the maximum-tolerated dose (MTD) of valproic acid (VA) combined with decitabine in acute myeloid leukemia (AML). Patients and Methods Twenty-five patients (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f653c829ed46001e382122d6adde7f31
https://pubmed.ncbi.nlm.nih.gov/17679729
https://pubmed.ncbi.nlm.nih.gov/17679729
Autor:
Chunhui Liu, Tamara Vukosavljevic, Jamie L. Ford, Christoph Plass, Laura J. Rush, Danilo Perrotti, John C. Byrd, Jianhua Yu, Lenguyen Huynh, Shujun Liu, Guido Marcucci, Marko I. Klisovic, Tiansheng Shen, Susan P. Whitman, Brian Becknell, Kun Sang Chang, Yu Li
Publikováno v:
Cancer research. 65(4)
The translocation t(8;21)(q22;q22) in acute myeloid leukemia (AML) results in the expression of the fusion protein RUNX1/MTG8, which in turn recruits histone deacetylases (HDAC) to silence RUNX1 target genes [e.g., interleukin-3 (IL-3)].We previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48db8950d5d590cb4f16f4c5e2b0caf8
https://pubmed.ncbi.nlm.nih.gov/15735013
https://pubmed.ncbi.nlm.nih.gov/15735013
Autor:
Lapo Alinari, Emilia Mahoney, John T. Patton, Xiaoli Zhang, Lenguyen Huynh, Christian Tyler Earl, Rajeswaran Mani, Yicheng Mao, Bo Yu, William H. Towns, Ching-Shih Chen, David M. Goldenberg, Kristie A. Blum, John C. Byrd, Natarajan Muthusamy, Mette Ibba, Robert A. Baiocchi
Publikováno v:
Blood. 118:600-600
Abstract 600 Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy with a short median survival despite multimodal therapy. FTY720, an immunosuppressive drug approved for the treatment of multiple sclerosis, promotes MCL cell death via down-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b98b7d316b81e739b5dafd1e83727b0c
https://doi.org/10.1182/blood.v118.21.600.600
https://doi.org/10.1182/blood.v118.21.600.600