Cell and context-dependent sorting of neuropathy-associated protein NDRG1 – insights from canine tissues and primary Schwann cell cultures

Autor: Fredrik S. Skedsmo, Michael A. Tranulis, Arild Espenes, Kristian Prydz, Kaspar Matiasek, Gjermund Gunnes, Lene C. Hermansen, Karin H. Jäderlund

Publikováno v: BMC Veterinary Research, Vol 15, Iss 1, Pp 1-17 (2019)

Abstract Background Mutations in the N-myc downstream-regulated gene 1 (NDRG1) can cause degenerative polyneuropathy in humans, dogs, and rodents. In humans, this motor and sensory neuropathy is known as Charcot-Marie-Tooth disease type 4D, and it is

Externí odkaz: https://doaj.org/article/14e0e190d6c9413eb626928187d1c447

Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D

Autor: Mette Berendt, Øyvind Stigen, Susan Skogtvedt Røed, Marit Hallvardsdotter Stafsnes, G. Diane Shelton, Karin Hultin Jäderlund, Inge Bjerkås, Zdenka Bartosova, Cecilia Rohdin, Lene C. Hermansen, Per Bruheim, Michael A. Tranulis, Kaspar Matiasek, Lars Moe, Arild Espenes, Fredrik Strebel Skedsmo, Merete Fredholm, Gjermund Gunnes

Publikováno v: Skedsmo, F S, Espenes, A, Tranulis, M A, Matiasek, K, Gunnes, G, Bjerkås, I, Moe, L, Røed, S S, Berendt, M, Fredholm, M, Rohdin, C, Shelton, G D, Bruheim, P, Stafsnes, M H, Bartosova, Z, Hermansen, L C, Stigen, Ø & Jäderlund, K H 2021, ' Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D ', Neuromuscular Disorders, vol. 31, no. 1, pp. 56-68 . https://doi.org/10.1016/j.nmd.2020.11.010
Neuromuscular Disorders

Mutations in the N-myc downstream-regulated gene 1 (NDRG1) cause degenerative polyneuropathy in ways that are poorly understood. We have investigated Alaskan Malamute dogs with neuropathy caused by a missense mutation in NDRG1. In affected animals, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3e1ea3056ea1bb21230ebe90899781
https://curis.ku.dk/ws/files/255355957/PIIS0960896620306751.pdf

Paraptosis-like cell death induced by yessotoxin

Autor: Lene C. Hermansen, Arild Espenes, Mónica Suárez Korsnes, Dyveke Lem Hetland

Publikováno v: Toxicology in Vitro. 25:1764-1770

This study shows that BC3H1 myoblast cell lines exposed to 100 nM yessotoxin (YTX) undergo a form of programmed cell death distinct from apoptosis and with features resembling paraptosis. Morphologically, cells treated with YTX reveal extensive cytop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754c17305d7a77b05151229b97ab4225
https://doi.org/10.1016/j.tiv.2011.09.005

Demographics of Giardia infections in Bergen, Norway, subsequent to a waterborne outbreak

Autor: Nina Langeland, Bjørn Gjerde, Torunn Forberg, Lene C. Hermansen, Lucy J. Robertson

Publikováno v: Scandinavian journal of infectious diseases. 40(2)

Young women have previously been reported as the predominant group infected during a waterborne giardiasis outbreak, due to elevated water consumption. Here, the demographics of those subsequently infected are described, and young women again predomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a665c0ae85454ba82d82dae4f495a938
https://pubmed.ncbi.nlm.nih.gov/17852919