Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lene Bonefeld"'
Autor:
David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link
Externí odkaz:
https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
Autor:
Katherine A. Fitzgerald, Bernadette Marrero, Siddharth Balachandran, Dylan G. Ryan, David Olagnier, Mona Motwani, Frank Vincenzo de Paoli, Marie B. Iversen, Yonglun Luo, Camilla Gunderstofte, Chenhe Su, Martin R. Jakobsen, Jacob Thyrsted, Hanne Christine Bertram, Aske M Brandtoft, Nikolaj L. Villadsen, Anne Kruse Hollensen, Christian K. Holm, Suraj Peri, Anne Louise Hansen, Christian Krapp, Victor Bruun, Long Yang, Virginia M. Artegoitia, Mette Nyegaard, Lin Lin, Anders Laustsen, Anne L. Thielke, Luke A. J. O'Neill, Thomas B. Poulsen, Christian Kroun Damgaard, Rongtuan Lin, Lene Bonefeld, Raphaela Goldbach-Mansky
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Olagnier, D, Brandtoft, A M, Gunderstofte, C, Villadsen, N L, Krapp, C, Thielke, A L, Laustsen, A, Peri, S, Hansen, A L, Bonefeld, L, Thyrsted, J, Bruun, V, Iversen, M B, Lin, L, Artegoitia, V M, Su, C, Yang, L, Lin, R, Balachandran, S, Luo, Y, Nyegaard, M, Marrero, B, Goldbach-Mansky, R, Motwani, M, Ryan, D G, Fitzgerald, K A, O'Neill, L A, Hollensen, A K, Damgaard, C K, de Paoli, F V, Bertram, H C, Jakobsen, M R, Poulsen, T B & Holm, C K 2018, ' Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming ', Nature Communications, vol. 9, no. 1, 3506 . https://doi.org/10.1038/s41467-018-05861-7
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Olagnier, D, Brandtoft, A M, Gunderstofte, C, Villadsen, N L, Krapp, C, Thielke, A L, Laustsen, A, Peri, S, Hansen, A L, Bonefeld, L, Thyrsted, J, Bruun, V, Iversen, M B, Lin, L, Artegoitia, V M, Su, C, Yang, L, Lin, R, Balachandran, S, Luo, Y, Nyegaard, M, Marrero, B, Goldbach-Mansky, R, Motwani, M, Ryan, D G, Fitzgerald, K A, O'Neill, L A, Hollensen, A K, Damgaard, C K, de Paoli, F V, Bertram, H C, Jakobsen, M R, Poulsen, T B & Holm, C K 2018, ' Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming ', Nature Communications, vol. 9, no. 1, 3506 . https://doi.org/10.1038/s41467-018-05861-7
The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an important negative regulator of STING and suggest a link be