Výsledky vyhledávání - "Lendon N. Pridgen"

An Efficient Synthesis of 2-Ethyl-7-chloro-4-methylthieno[4,3,2-e,f][3]benzazepine (SK&F 106686)viaBromomethylation of 2-Ethyl-5-chlorobenzo[b]thiophene

Autor: Ann Marie Tickner, K. Huang, Robert John Mills, S. Shilcrat, Lendon N. Pridgen

Publikováno v: Synthetic Communications. 28:3479-3489

The synthesis of 2-ethyl-3-bromoethyl-5-chlorobenzo[b]thiophene (6) is described using a unique phase transfer catalyzed bromoethylation of 2-ethyl-5-chlorobenzo[b]thiophene (5). Compound 6 was converted in six steps and in 55% overall yield to the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43b29397aa2f055b5bacf4936b630652
https://doi.org/10.1080/00397919808004456

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A stereospecific synthesis of both enantiomers of 2-(1′-amino-2′-methylpropyl) imidazole, a key synthon in the synthesis of SB 203386; a potent protease inhibitor

Autor: Mohamed K. Mokhallalati, Michael A. McGuire, Lendon N. Pridgen

Publikováno v: Tetrahedron Letters. 38:1275-1278

Two methods for the asymmetric synthesis of both enantiomers of 2-(1′-amino-2′-methylpropyl)imidazole ( 2 ) have been developed by adding nucleophilic organometallics to nonracemic 2-oxazolidinones employing 2-phenylglycinol as the source of chir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::853d3f0b21cde7414c28b92030e761cc
https://doi.org/10.1016/s0040-4039(97)00070-1

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Enantioselective synthesis of α-amino acetals (aldehydes) via nucleophilic 1,2-addition to chiral 1,3-oxazolidines

Autor: K.Raman Muralidharan, Mohamed K. Mokhallalati, Lendon N. Pridgen

Publikováno v: Tetrahedron Letters. 35:7489-7492

A general procedure for the diastereoselective addition of Grignard reagents to chiral 2-(4,4,6,6-tetramethyl-1,3-dioxan-2-yl)-4-substituted-1,3-oxazolidines 4 is described. Chemical yields and diastereoselectivities are generally excellent (91–100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::310157c23bf4179525a6d9939d8f4e60
https://doi.org/10.1016/s0040-4039(00)78325-0

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A single-pot synthesis of 1,1,2-trisubstituted 1,2-dihydronaphthalenes in high enantiomeric purity

Autor: Lendon N. Pridgen, K.Raman Muralidharan, Mohamed K. Mokhallalati

Publikováno v: Tetrahedron Letters. 35:4267-4270

A diastereoselective addition of Grignard reagents to nonracemic 2-(1-naphthyl)-4-(4R)-phenyl-1,3-oxazolidines ( 1 ) followed by electrophilic trapping of the azaenolate is described. This tandem addition was performed in a single flask producing 1,1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3af3b6730b20c130ce035fa12362532
https://doi.org/10.1016/s0040-4039(00)73330-2

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Heteroarylation of 6-Aryl-2,3-dihydroimidazo[2,1-b]thiazole withN-(Ethoxycarbonyl)heteroaromatic Salts

Autor: David B. Staiger, Lendon N. Pridgen, Michael Anthony Mcguire, Louisa Lam Davis, Drake S. Eggleston, Ivan Lantos, S. C. Shilcrat, Lee Webb

Publikováno v: Journal of Heterocyclic Chemistry. 30:1663-1671

The ethyl chloroformate salts of a variety of benzo-fused six membered π-deficient heteroaromatics, including quinoline, isoquinoline, 4-chloroquinoline, 3-bromoquinoline, phthalazine, and quinazoline, reacted with 6-aryl-2,3-dihydroimidazo[2,1-b]th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1368b2982588106121b22344666a526a
https://doi.org/10.1002/jhet.5570300634

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Chelation control in metal-assisted aldol addition reactions of .alpha.-N-halogenated imide enolates leading to predominantly anti stereoselectivity. An example of a stereocontrolled Darzens reaction

Autor: Susan Shilcrat, Drake S. Eggleston, Ahmed F. Abdel-Magid, Ivan Lantos, Lendon N. Pridgen

Publikováno v: The Journal of Organic Chemistry. 58:5107-5117

The aldol reaction of enantiopure N-(haloacetyl)-2-oxazolidinone enolates with aromatic aldehydes was studied for conditions that would induce the reaction to yield predominantly anti adducts. It was found herein that the inherent steric and stereoel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04f8b55e21343c2f5fd9450825d7a7ed
https://doi.org/10.1021/jo00071a020

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Lead Tetraacetate Cleavage of Chiral Phenylglycinol Derived Secondary Amines Without Racemization

Autor: Mohamed K. Mokhallalati, Lendon N. Pridgen

Publikováno v: Synthetic Communications. 23:2055-2064

Diastereomerically enriched N-(1,1-disubstituted methyl)(2 ‘-hydroxyl’-phenylethyl) amines were oxidatively converted to enantiomerically enriched primary disubstituted methylamines in excellent yields without racemization, using an improved lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4345f6b9989daf3c7de094b27086fff7
https://doi.org/10.1080/00397919308009866

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An efficient enantiomeric three step synthesis of β-amino acids (esters)

Autor: M.‐J. Wu, Lendon N. Pridgen, Mohamed K. Mokhallalati

Publikováno v: Tetrahedron Letters. 34:47-50

Ethyl tributylstannylacetate was reacted with (R)-2-aryl or alkyl-1,3-oxazolidines 6 under very specific (ZnCl2/Et2O·BF3, 0.5 equiv each) Lewis Acid catalysed conditions to yield (1R, 1′R)-N-2′-hydroxy-1′-phenylethyl-1-aryl or alkyl-2-carboeth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ff59bdf6ff9d3e5b0e00ec9edf2aaf8
https://doi.org/10.1016/s0040-4039(00)60054-0

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