Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lendl Tan"'
Autor:
Miljan Stupar, Lendl Tan, Edward D. Kerr, Christopher J. De Voss, Brian M. Forde, Benjamin L. Schulz, Nicholas P. West
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The ability of Mycobacterium tuberculosis (Mtb) to persist in the host complicates and prolongs tuberculosis (TB) patient chemotherapy. Here we demonstrate that a neglected two-component system (TCS) of Mtb, TcrXY, is an autoregulated acid-s
Externí odkaz:
https://doaj.org/article/54acaefe3dc54bb8a1d52f6454f667e1
Publikováno v:
Marine Drugs, Vol 22, Iss 7, p 298 (2024)
Tuberculosis remains a significant global health pandemic. There is an urgent need for new anti-tubercular agents to combat the rising incidence of drug resistance and to offer effective and additive therapeutic options. High-throughput screening of
Externí odkaz:
https://doaj.org/article/90debecfbc8e405cb567616a62ee7621
Autor:
Steven J Hancock, Alvin W Lo, Thomas Ve, Christopher J Day, Lendl Tan, Alejandra A Mendez, Minh-Duy Phan, Nguyen Thi Khanh Nhu, Kate M Peters, Amanda C Richards, Brittany A Fleming, Chyden Chang, Dalton H Y Ngu, Brian M Forde, Thomas Haselhorst, Kelvin G K Goh, Scott A Beatson, Michael P Jennings, Matthew A Mulvey, Bostjan Kobe, Mark A Schembri
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010582 (2022)
Extra-intestinal pathogenic Escherichia coli (ExPEC) belong to a critical priority group of antibiotic resistant pathogens. ExPEC establish gut reservoirs that seed infection of the urinary tract and bloodstream, but the mechanisms of gut colonisatio
Externí odkaz:
https://doaj.org/article/8db3f6a677d84c3bb2b4d5630d12441f
Autor:
Mark A. T. Blaskovich, Angela M. Kavanagh, Alysha G. Elliott, Bing Zhang, Soumya Ramu, Maite Amado, Gabrielle J. Lowe, Alexandra O. Hinton, Do Minh Thu Pham, Johannes Zuegg, Neil Beare, Diana Quach, Marc D. Sharp, Joe Pogliano, Ashleigh P. Rogers, Dena Lyras, Lendl Tan, Nicholas P. West, David W. Crawford, Marnie L. Peterson, Matthew Callahan, Michael Thurn
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae. This article highlig
Externí odkaz:
https://doaj.org/article/65481cd7aaae4aba9fec4f20abbf1366
Autor:
Jason J. Paxman, Alvin W. Lo, Matthew J. Sullivan, Santosh Panjikar, Michael Kuiper, Andrew E. Whitten, Geqing Wang, Chi-Hao Luan, Danilo G. Moriel, Lendl Tan, Kate M. Peters, Minh-Duy Phan, Christine L. Gee, Glen C. Ulett, Mark A. Schembri, Begoña Heras
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Autotransporter proteins are localised to the bacterial surface and promote colonisation of host epithelial surfaces. Here, the authors present the crystal structure of autotransporter UpaB and show evidence for distinct binding sites for glycosamino
Externí odkaz:
https://doaj.org/article/84181b0a975c40f082db3fb0320d1436
Publikováno v:
PeerJ, Vol 6, p e5146 (2018)
Homologous alignment cloning (HAC) is a rapid method of molecular cloning that facilitates low-cost, highly efficient cloning of polymerase chain reaction products into any plasmid vector in approximately 2 min. HAC facilitates insert integration due
Externí odkaz:
https://doaj.org/article/e7ab1453902347bcbbeb5ef32d3796a1
Autor:
Danilo G. Moriel, Lendl Tan, Kelvin G. K. Goh, Minh-Duy Phan, Deepak S. Ipe, Alvin W. Lo, Kate M. Peters, Glen C. Ulett, Scott A. Beatson, Mark A. Schembri
Publikováno v:
mSphere, Vol 1, Iss 6 (2016)
ABSTRACT Escherichia coli is a versatile pathogen capable of causing intestinal and extraintestinal infections that result in a huge burden of global human disease. The diversity of E. coli is reflected by its multiple different pathotypes and mosaic
Externí odkaz:
https://doaj.org/article/8f46350c3e904893b09e7efda4a7cb05
Autor:
Danilo G. Moriel, Begoña Heras, Jason J. Paxman, Alvin W. Lo, Lendl Tan, Matthew J. Sullivan, Samantha J. Dando, Scott A. Beatson, Glen C. Ulett, Mark A. Schembri
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Urinary tract infection (UTI) is a disease of extremely high incidence in both community and nosocomial settings. UTIs cause significant morbidity and mortality, with approximately 150 million cases globally per year. Uropathogenic Escherich
Externí odkaz:
https://doaj.org/article/fc01d4caa3354732be0b81f157eb1bd7
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162391 (2016)
Extra-intestinal pathogenic Escherichia coli (ExPEC) are responsible for diverse infections including meningitis, sepsis and urinary tract infections. The alarming rise in anti-microbial resistance amongst ExPEC complicates treatment and has highligh
Externí odkaz:
https://doaj.org/article/38fd54ffa65941dda6c5dfd6269fb4a2
Autor:
Chee Wei Ang, Brendon M. Lee, Colin J. Jackson, Yuehong Wang, Scott G. Franzblau, Amanda F. Francisco, John M. Kelly, Paul V. Bernhardt, Lendl Tan, Nicholas P. West, Melissa L. Sykes, Alexandra O. Hinton, Raghu Bolisetti, Vicky M. Avery, Matthew A. Cooper, Mark A.T. Blaskovich
Publikováno v:
Journal of Medicinal Chemistry. 65:13125-13142
Tuberculosis remains one of the leading causes of death from a single infectious agent, surpassing both AIDS and malaria. In recent years, two bicyclic nitroimidazole drugs, delamanid and pretomanid have been approved to treat this airborne infection