Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Lendl, Tan"'
Autor:
Miljan Stupar, Lendl Tan, Edward D. Kerr, Christopher J. De Voss, Brian M. Forde, Benjamin L. Schulz, Nicholas P. West
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The ability of Mycobacterium tuberculosis (Mtb) to persist in the host complicates and prolongs tuberculosis (TB) patient chemotherapy. Here we demonstrate that a neglected two-component system (TCS) of Mtb, TcrXY, is an autoregulated acid-s
Externí odkaz:
https://doaj.org/article/54acaefe3dc54bb8a1d52f6454f667e1
Publikováno v:
Marine Drugs, Vol 22, Iss 7, p 298 (2024)
Tuberculosis remains a significant global health pandemic. There is an urgent need for new anti-tubercular agents to combat the rising incidence of drug resistance and to offer effective and additive therapeutic options. High-throughput screening of
Externí odkaz:
https://doaj.org/article/90debecfbc8e405cb567616a62ee7621
Autor:
Mark A. T. Blaskovich, Angela M. Kavanagh, Alysha G. Elliott, Bing Zhang, Soumya Ramu, Maite Amado, Gabrielle J. Lowe, Alexandra O. Hinton, Do Minh Thu Pham, Johannes Zuegg, Neil Beare, Diana Quach, Marc D. Sharp, Joe Pogliano, Ashleigh P. Rogers, Dena Lyras, Lendl Tan, Nicholas P. West, David W. Crawford, Marnie L. Peterson, Matthew Callahan, Michael Thurn
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae. This article highlig
Externí odkaz:
https://doaj.org/article/65481cd7aaae4aba9fec4f20abbf1366
Autor:
Steven J Hancock, Alvin W Lo, Thomas Ve, Christopher J Day, Lendl Tan, Alejandra A Mendez, Minh-Duy Phan, Nguyen Thi Khanh Nhu, Kate M Peters, Amanda C Richards, Brittany A Fleming, Chyden Chang, Dalton H Y Ngu, Brian M Forde, Thomas Haselhorst, Kelvin G K Goh, Scott A Beatson, Michael P Jennings, Matthew A Mulvey, Bostjan Kobe, Mark A Schembri
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010582 (2022)
Extra-intestinal pathogenic Escherichia coli (ExPEC) belong to a critical priority group of antibiotic resistant pathogens. ExPEC establish gut reservoirs that seed infection of the urinary tract and bloodstream, but the mechanisms of gut colonisatio
Externí odkaz:
https://doaj.org/article/8db3f6a677d84c3bb2b4d5630d12441f
Autor:
Jason J. Paxman, Alvin W. Lo, Matthew J. Sullivan, Santosh Panjikar, Michael Kuiper, Andrew E. Whitten, Geqing Wang, Chi-Hao Luan, Danilo G. Moriel, Lendl Tan, Kate M. Peters, Minh-Duy Phan, Christine L. Gee, Glen C. Ulett, Mark A. Schembri, Begoña Heras
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Autotransporter proteins are localised to the bacterial surface and promote colonisation of host epithelial surfaces. Here, the authors present the crystal structure of autotransporter UpaB and show evidence for distinct binding sites for glycosamino
Externí odkaz:
https://doaj.org/article/84181b0a975c40f082db3fb0320d1436
Autor:
Chee Wei Ang, Brendon M. Lee, Colin J. Jackson, Yuehong Wang, Scott G. Franzblau, Amanda F. Francisco, John M. Kelly, Paul V. Bernhardt, Lendl Tan, Nicholas P. West, Melissa L. Sykes, Alexandra O. Hinton, Raghu Bolisetti, Vicky M. Avery, Matthew A. Cooper, Mark A.T. Blaskovich
Publikováno v:
Journal of Medicinal Chemistry. 65:13125-13142
Tuberculosis remains one of the leading causes of death from a single infectious agent, surpassing both AIDS and malaria. In recent years, two bicyclic nitroimidazole drugs, delamanid and pretomanid have been approved to treat this airborne infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48815ad0d1eeea35672ca673f74e283c
https://doi.org/10.1021/acs.jmedchem.2c00972
https://doi.org/10.1021/acs.jmedchem.2c00972
Autor:
Miljan Stupar, Lendl Tan, Edward Kerr, Christopher De Voss, Brian Forde, Benjamin Schulz, Nicholas P. West
The ability of Mycobacterium tuberculosis (Mtb) to persist in the host complicates and prolongs tuberculosis (TB) patient chemotherapy. Here we demonstrate that a neglected two-component system (TCS) of Mtb, TcrXY, is an autoregulated acid-sensing TC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f1c3f06dfae1682986490426443ffbe
https://doi.org/10.21203/rs.3.rs-2847166/v1
https://doi.org/10.21203/rs.3.rs-2847166/v1
Publikováno v:
Molecular Microbiology. 117:973-985
Intracellular bacterial pathogens such as Mycobacterium tuberculosis are remarkably adept at surviving within a host, employing a variety of mechanisms to counteract host defenses and establish a protected niche. Constant surveying of the environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc97491ec05d360459731b02fe40ba4
https://doi.org/10.1111/mmi.14899
https://doi.org/10.1111/mmi.14899
Autor:
Begoña Heras, Samantha J. Dando, Mark A. Schembri, Jason J. Paxman, Glen C. Ulett, Matthew J. Sullivan, Scott A. Beatson, Lendl Tan, Danilo Gomes Moriel, Alvin W. Lo
Publikováno v:
mBio, Vol 7, Iss 2, p e02046-15 (2016)
mBio
mBio, Vol 7, Iss 2 (2016)
mBio
mBio, Vol 7, Iss 2 (2016)
Urinary tract infection (UTI) is a disease of extremely high incidence in both community and nosocomial settings. UTIs cause significant morbidity and mortality, with approximately 150 million cases globally per year. Uropathogenic Escherichia coli (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8464f5f21fcf23435927153b67e0e2cb