Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lendell L. Cummins"'
Autor:
Elena Jordana-Lluch, Heather E Carolan, Montserrat Giménez, Rangarajan Sampath, David J Ecker, M Dolores Quesada, Josep M Mòdol, Fernando Arméstar, Lawrence B Blyn, Lendell L Cummins, Vicente Ausina, Elisa Martró
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62108 (2013)
Achieving a rapid microbiological diagnosis is crucial for decreasing morbidity and mortality of patients with a bloodstream infection, as it leads to the administration of an appropriate empiric antimicrobial therapy. Molecular methods may offer a r
Externí odkaz:
https://doaj.org/article/c6faf736f9f94ab7bb80ca75ec953927
Autor:
Michelle A. Toro, David J. Ecker, Rangarajan Sampath, Charles W. Stratton, Mark W. Eshoo, Thomas G. Laffler, Criziel D. Quinn, Lawrence B. Blyn, Lendell L. Cummins, Yi-Wei Tang, Donna Toleno, Colt M. McClain, Megan A. Rounds, Heather E. Carolan
Publikováno v:
Journal of Clinical Microbiology. 51:3535-3541
A prospective study was performed to determine the value of direct molecular testing of whole blood for detecting the presence of culturable and unculturable bacteria and yeasts in patients with suspected bloodstream infections. A total of 464 adult
Autor:
Mark W. Eshoo, Duane J. Knize, Fred Hajjar, Kristin A. Sannes-Lowery, Maria Tobarmosquera, Karl Rudnick, Sheri Manalili, Yun Jiang, Demetrius J. Walcott, James C. Hannis, Jared J. Drader, Feng Li, Christian Massire, Vanessa Harpin, Amy Schink, Jose R. Gutierrez, Brian Libby, Steven A. Hofstadler, Lawrence B. Blyn, Harold B. Levene, David Robbins, Lendell L. Cummins, Rachael Melton, Raymond Ranken, Vivek Samant, Rangarajan Sampath, Michael Pear, David J. Ecker, Thomas A. Hall, Abel Gutierrez, Neill White, Christina Ivy, Joseph A. Ecker
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 11:341-351
We describe a new approach to the sensitive and specific identification of bacteria, viruses, fungi, and protozoa based on broad-range PCR and high-performance mass spectrometry. The Ibis T5000 is based on technology developed for the Department of D
Autor:
Christian Massire, John Mcneil, Neill White, Rachael Melton, Raymond Ranken, Duane J. Knize, Cristina Ivy, Vanessa Zapp, Lendell L. Cummins, Mark W. Eshoo, Vivek Samant, Anjali Desai, Steven A. Hofstadler, Harold B. Levene, David Robbins, Kristin A. Sannes-Lowery, Amy Schink, Sheri Manalili, David J. Ecker, Yun Jiang, Thomas A. Hall, Greg Barrett-Wilt, Demetrius J. Walcott, Jared J. Drader, Emily Moradi, Rangarajan Sampath, James C. Hannis, Brian Libby, Lawrence B. Blyn, Feng Li, Karl Rudnick, Jose R. Gutierrez
Publikováno v:
International Journal of Mass Spectrometry. 242:23-41
In this work, we describe a strategy for the detection and characterization of microorganisms associated with a potential biological warfare attack or a natural outbreak of an emerging infectious disease. This approach, termed TIGER (Triangulation Id
Autor:
Kristin A. Sannes-Lowery, Shuo Chen, Jared J. Drader, Lendell L. Cummins, Steven A. Hofstadler
Publikováno v:
International Journal of Mass Spectrometry. 238:197-206
Ribonucleic acids (RNA) are an attractive target for drug discovery since they play critical roles in cellular functions. Because small structured subdomains are known to mimic the behavior of the entire RNA, it is possible to design RNA drug targets
Autor:
Jared J. Drader, Steven A. Hofstadler, Richard H. Griffey, Kristin A. Sannes-Lowery, Shuo Chen, Lendell L. Cummins, Larry B. Blyn
Publikováno v:
Journal of Natural Products. 66:1186-1190
In this work we describe a high-throughput screening approach based on electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR) that rapidly interrogates the noncovalent interaction between RNA-based drug target
Autor:
Feifei Wang, Christian Massire, Chanyi Lu, Feng Li, Lingyun Shao, Shu Zhang, David J. Ecker, Xiaoping Fan, Shufang Meng, Haijing Li, Wenhong Zhang, Lendell L. Cummins, Jing Wu, Rangarajan Sampath, Lawrence B. Blyn, Sen Wang, Jialin Jin, Yi-Wei Tang
Publikováno v:
Journal of Clinical Microbiology. 49:2719-2721
We used multilocus PCR and electrospray ionization mass spectrometry (PCR/ESI-MS) to determine the genotype and drug resistance profiles for 96 Mycobacterium tuberculosis isolates circulating in regions of high and low tuberculosis (TB) endemicity in
Autor:
Robert Mckay, Stephen Owens, Lendell L. Cummins, Loren Miraglia, Nicholas M. Dean, Henri Sasmor
Publikováno v:
Journal of Biological Chemistry. 274:1715-1722
The use of antisense oligonucleotides to inhibit the expression of targeted mRNA sequences is becoming increasingly commonplace. Although effective, the most widely used oligonucleotide modification (phosphorothioate) has some limitations. In previou
Publikováno v:
Biotechnology and Bioengineering. 61:169-177
Capillary electrophoresis has been applied to monitor model reactions in solution-phase combinatorial chemistry. In particular, the simultaneous alkylation reactions of secondary amines with a series of benzyl halides has been investigated. Reactant
Autor:
Rigo Herrmann, Lendell L. Cummins, Becky D. Haly, Haoyun An, Hans Gaus, P. Dan Cook, Richard H. Griffey
Publikováno v:
Tetrahedron. 54:4067-4076
The rapid deconvolution of combinatorial libraries prepared via solution-phase simultaneous addition of functionalities is demonstrated using HPLC. Libraries containing 25–216 members are screened for biological activity, and active libraries are f