A synthetic peptide mimic kills Candida albicans and synergistically prevents infection.

Autor: Schaefer S; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, NSW, Australia.; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, NSW, Australia.; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Vij R; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Sprague JL; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Austermeier S; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Dinh H; ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, North Ryde, NSW, Australia., Judzewitsch PR; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, NSW, Australia., Müller-Loennies S; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, Borstel, Germany., Lopes Silva T; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Seemann E; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany., Qualmann B; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany., Hertweck C; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany.; Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany., Scherlach K; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Gutsmann T; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany., Cain AK; ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, North Ryde, NSW, Australia., Corrigan N; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, NSW, Australia., Gresnigt MS; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany.; Junior Research Group Adaptive Pathogenicity Strategies, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Boyer C; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW, Australia. cboyer@unsw.edu.au.; Australian Centre for NanoMedicine, UNSW, Sydney, NSW, Australia. cboyer@unsw.edu.au., Lenardon MD; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, NSW, Australia. m.lenardon@unsw.edu.au., Brunke S; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany. sascha.brunke@leibniz-hki.de.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 09; Vol. 15 (1), pp. 6818. Date of Electronic Publication: 2024 Aug 09.

Mimicking Charged Host-Defense Peptides to Tune the Antifungal Activity and Biocompatibility of Amphiphilic Polymers.

Autor: Schaefer S; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, New South Wales 2052, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, New South Wales 2052, Australia.; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales 2052, Australia., Melodia D; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, New South Wales 2052, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, New South Wales 2052, Australia., Pracey C; Nuclear Magnetic Resonance Facility, Mark Wainwright Analytical Centre, UNSW, Sydney, New South Wales 2052, Australia., Corrigan N; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, New South Wales 2052, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, New South Wales 2052, Australia., Lenardon MD; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales 2052, Australia., Boyer C; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, New South Wales 2052, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, New South Wales 2052, Australia.

Publikováno v: Biomacromolecules [Biomacromolecules] 2024 Feb 12; Vol. 25 (2), pp. 871-889. Date of Electronic Publication: 2024 Jan 02.

Human gut bifidobacteria inhibit the growth of the opportunistic fungal pathogen Candida albicans.

Autor: Ricci L; Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom.; CIBIO - Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, 38123, Italy., Mackie J; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom., Donachie GE; Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom., Chapuis A; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom., Mezerová K; Department of Microbiology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, 77515, Czech Republic., Lenardon MD; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom.; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Brown AJP; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom.; MRC Centre for Medical Mycology, University of Exeter, Exeter, EX4 4QD, United Kingdom., Duncan SH; Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom., Walker AW; Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom.

Publikováno v: FEMS microbiology ecology [FEMS Microbiol Ecol] 2022 Sep 19; Vol. 98 (10).

Rational Design of an Antifungal Polyacrylamide Library with Reduced Host-Cell Toxicity.

Autor: Schaefer S; School of Chemical Engineering, UNSW, Sydney, New South Wales 2052, Australia.; Australian Centre for Nanomedicine, UNSW, Sydney, New South Wales 2052, Australia.; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, 07745 Jena, Germany., Pham TTP; School of Chemical Engineering, UNSW, Sydney, New South Wales 2052, Australia.; Australian Centre for Nanomedicine, UNSW, Sydney, New South Wales 2052, Australia., Brunke S; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, 07745 Jena, Germany., Hube B; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, 07745 Jena, Germany.; Institute of Microbiology, Friedrich Schiller University, 07743 Jena, Germany., Jung K; School of Chemical Engineering, UNSW, Sydney, New South Wales 2052, Australia.; Australian Centre for Nanomedicine, UNSW, Sydney, New South Wales 2052, Australia., Lenardon MD; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, New South Wales 2052, Australia., Boyer C; School of Chemical Engineering, UNSW, Sydney, New South Wales 2052, Australia.; Australian Centre for Nanomedicine, UNSW, Sydney, New South Wales 2052, Australia.

Publikováno v: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Jun 16; Vol. 13 (23), pp. 27430-27444. Date of Electronic Publication: 2021 Jun 01.

The Viscoelastic Properties of the Fungal Cell Wall Allow Traffic of AmBisome as Intact Liposome Vesicles.

Autor: Walker L; Aberdeen Fungal Group, Institute of Medical Sciences, Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Foresterhill, Aberdeen, United Kingdom., Sood P; Aberdeen Fungal Group, Institute of Medical Sciences, Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Foresterhill, Aberdeen, United Kingdom., Lenardon MD; Aberdeen Fungal Group, Institute of Medical Sciences, Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Foresterhill, Aberdeen, United Kingdom.; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Milne G; Aberdeen Fungal Group, Institute of Medical Sciences, Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Foresterhill, Aberdeen, United Kingdom., Olson J; Gilead Sciences Inc., San Dimas, California, USA., Jensen G; Gilead Sciences Inc., San Dimas, California, USA., Wolf J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Casadevall A; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Adler-Moore J; Cal Poly Pomona, Pomona, California, USA., Gow NAR; Aberdeen Fungal Group, Institute of Medical Sciences, Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Foresterhill, Aberdeen, United Kingdom n.gow@abdn.ac.uk.

Publikováno v: MBio [mBio] 2018 Feb 06; Vol. 9 (1). Date of Electronic Publication: 2018 Feb 06.