Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.

Autor: Krister Bamberg, Ulrika Johansson, Karl Edman, Lena William-Olsson, Susanna Myhre, Anders Gunnarsson, Stefan Geschwindner, Anna Aagaard, Anna Björnson Granqvist, Frédéric Jaisser, Yufeng Huang, Kenneth L Granberg, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0193380 (2018)

Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart failure, but their use is limited due to the compound class-inherent hyperka

Externí odkaz: https://doaj.org/article/837696cf2e364f56bb14da55aad00b11

Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis

Autor: Daniel Lindén, Lena William-Olsson, Magdalena Rhedin, Anna-Karin Asztély, John C. Clapham, Sandra Schreyer

Publikováno v: Journal of Lipid Research, Vol 45, Iss 7, Pp 1279-1288 (2004)

Glycerol-3-phosphate acyltransferase (GPAT) catalyses the first committed step in glycerolipid biosynthesis. The mitochondrial isoform (mtGPAT) is mainly expressed in liver, where it is highly regulated, indicating that mtGPAT may have a unique role

Externí odkaz: https://doaj.org/article/1ab501f64cb840eeb6834a6084b53302

High-protein diet accelerates diabetes and kidney disease in the BTBRob/ob mouse

Autor: Anna Björnson Granqvist, Jose Miguel Sanchez, Giovanni Pellegrini, Kelly L. Hudkins, Anette Ericsson, Ulrika Dahlqvist, Magnus Söderberg, Tajana Tesan Tomic, Charles E. Alpers, Lena William-Olsson, Pernilla Tonelius, Ann-Katrin Andersson

Publikováno v: American Journal of Physiology-Renal Physiology. 318:F763-F771

There is a need for improved animal models that better translate to human kidney disease to predict outcome of pharmacological effects in the patient. The diabetic BTBR ob/ob mouse model mimics key features of early diabetic nephropathy in humans, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33e299cb7da011959db08b9d87b8ac1f
https://doi.org/10.1152/ajprenal.00484.2019

Direct Drug Delivery to Kidney via the Renal Artery

Autor: Camilla Enggaard, Ulrika Dahlqvist, Jane Stubbe, Anna Björnson Granqvist, Magnus Söderberg, Alex-Xianghua Zhou, Tajana Tesan Tomic, Lena William-Olsson, Anette Ericsson

Publikováno v: Dahlqvist, U, Tomic, T T, Söderberg, M, Stubbe, J, Enggaard, C, Ericsson, A & Zhou, A-X 2021, ' Direct Drug Delivery to Kidney via the Renal Artery ', Journal of Visualized Experiments, vol. 170, e61932 . https://doi.org/10.3791/61932

There is a need for directed injections to enable increased and specific renal exposure for efficient evaluation of drug targets in the renal research field. Accumulation of drugs in certain organs may give rise to adverse and unwanted effects, depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b775e51d215091f9b7648d94835b0bc
https://doi.org/10.3791/61932-v

P0658MATRIX AND FLOW MODULATE GENE EXPRESSION IN A 3D VASCULARISED TUBULE MODEL

Autor: Babak Alaei, Annette Bak, Sanlin Robinson, Maryam Clausen, Julie Williams, Pernille Laerkegaard Hansen, Graham Belfield, Ryan Hicks, Kimberly A. Homan, Lena William-Olsson, Jennifer A. Lewis

Publikováno v: Nephrology Dialysis Transplantation. 35

Background and Aims Questions abound regarding the translation of in vitro 2D cell culture systems to the human setting. This is especially true of the kidney in which there is a complex hierarchical structure and a multitude of cell types. While it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ce266b748e48af6068ec061a4d87de7
https://doi.org/10.1093/ndt/gfaa142.p0658