Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lena Wartosch"'
Autor:
Harriet Crawley-Snowdon, Ji-Chun Yang, Nathan R. Zaccai, Luther J. Davis, Lena Wartosch, Emily K. Herman, Nicholas A. Bright, James S. Swarbrick, Brett M. Collins, Lauren P. Jackson, Matthew N. J. Seaman, J. Paul Luzio, Joel B. Dacks, David Neuhaus, David J. Owen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
VARP is bound to endosomes and functions as a protein:protein interaction platform. Here, the authors present the NMR structure of the complex between the retromer subunit VPS29 and a VARP Zn-fingernail microdomain that is structurally distinct from
Externí odkaz:
https://doaj.org/article/5179c14a82ba4080bfd7a8f14df6270f
Publikováno v:
Bone. 168:116639
After the discovery of abundant v-ATPase complexes in the osteoclast ruffled membrane it was obvious that in parallel a negative counter-ion needs to be transported across this membrane to allow for efficient transport of protons into the resorption
Autor:
J. Paul Luzio, Brett M. Collins, Nicholas A. Bright, Joel B. Dacks, James S. Swarbrick, Lena Wartosch, Harriet Crawley-Snowdon, Ji-Chun Yang, Luther J. Davis, Nathan R. Zaccai, Lauren P. Jackson, David J. Owen, Matthew N.J. Seaman, David Neuhaus, Emily K. Herman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Funder: Discovery Grants from the Natural Sciences and Engineering Research Council of Canada (RES0043758, RES0046091)
VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-r
VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-r
Autor:
Michael D.J. Parkinson, Luther J. Davis, Andrew A. Peden, J. Paul Luzio, Lena Wartosch, Nicholas A. Bright, Judith Mantell, James R. Edgar
Publikováno v:
Davis, L J, Bright, N A, Edgar, J R, Parkinson, M D J, Wartosch, L, Mantell, J M, Pedan, A A & Luzio, J P 2021, ' Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway ', Journal of Cell Science, vol. 134, no. 10, jcs255463 . https://doi.org/10.1242/jcs.255463
Journal of Cell Science
article-version (VoR) Version of Record
Journal of Cell Science
article-version (VoR) Version of Record
To provide insights into the kiss-and-run and full fusion events resulting in endocytic delivery to lysosomes, we investigated conditions causing increased tethering and pore formation between late endocytic organelles in HeLa cells. Knockout of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a83b6f9f1fc8c7e1f1f0a750cf1e98
https://hdl.handle.net/1983/42c57471-e32d-4a11-a5b1-16a7d167d1cc
https://hdl.handle.net/1983/42c57471-e32d-4a11-a5b1-16a7d167d1cc
Autor:
Lena Wartosch, Karen Schindler, Melina Schuh, Jennifer R. Gruhn, Eva R. Hoffmann, Rajiv C. McCoy, Jinchuan Xing
Publikováno v:
Prenatal Diagnosis. 41
Autor:
Andrea Ballabio, Aleksey Shatunov, Lena E Nikolaeva, Elena Pavlova, J. Paul Luzio, Alena I Moskvina, Timothy M. Cox, Lena Wartosch, Karen Tylee, Nicholas A. Bright, Heather J. Church
Publikováno v:
Human Molecular Genetics
A rare lysosomal disease resembling a mucopolysaccharidosis with unusual systemic features, including renal disease and platelet dysfunction, caused by the defect in a conserved region of the VPS33A gene on human chromosome 12q24.31, occurs in Yakuts
Publikováno v:
Progress in molecular and subcellular biology. 57
In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The c
Publikováno v:
Endocytosis and Signaling ISBN: 9783319967035
In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b430d589331af0f82f12acf4b873e9
https://doi.org/10.1007/978-3-319-96704-2_6
https://doi.org/10.1007/978-3-319-96704-2_6
Autor:
Anita K, Ho, Jane L, Wagstaff, Paul T, Manna, Lena, Wartosch, Seema, Qamar, Elspeth F, Garman, Stefan M V, Freund, Rhys C, Roberts
Publikováno v:
BMC Biology
Background Mutations in Lipopolysaccharide-induced tumour necrosis factor-α factor (LITAF) cause the autosomal dominant inherited peripheral neuropathy, Charcot-Marie-Tooth disease type 1C (CMT1C). LITAF encodes a 17 kDa protein containing an N-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::15e79749af59ee8fa339c4af51274bc0
https://doi.org/10.1186/s12915-016-0332-8
https://doi.org/10.1186/s12915-016-0332-8
Autor:
M.C. de Vernejoul, Jens C. Fuhrmann, Thomas J. Jentsch, Uwe Kornak, C. Schlack, Chayarop Supanchart, Lena Wartosch, Dieter Felsenberg, Jirko Kühnisch
Publikováno v:
Bone. 58:92-102
Mutations in the 2Cl(-)/1H(+)-exchanger ClC-7 impair osteoclast function and cause different types of osteoclast-rich osteopetrosis. However, it is unknown to what extent ClC-7 function has to be reduced to become rate-limiting for bone resorption. I