Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29

Autor: Harriet Crawley-Snowdon, Ji-Chun Yang, Nathan R. Zaccai, Luther J. Davis, Lena Wartosch, Emily K. Herman, Nicholas A. Bright, James S. Swarbrick, Brett M. Collins, Lauren P. Jackson, Matthew N. J. Seaman, J. Paul Luzio, Joel B. Dacks, David Neuhaus, David J. Owen

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

VARP is bound to endosomes and functions as a protein:protein interaction platform. Here, the authors present the NMR structure of the complex between the retromer subunit VPS29 and a VARP Zn-fingernail microdomain that is structurally distinct from

Externí odkaz: https://doaj.org/article/5179c14a82ba4080bfd7a8f14df6270f

Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29

Autor: J. Paul Luzio, Brett M. Collins, Nicholas A. Bright, Joel B. Dacks, James S. Swarbrick, Lena Wartosch, Harriet Crawley-Snowdon, Ji-Chun Yang, Luther J. Davis, Nathan R. Zaccai, Lauren P. Jackson, David J. Owen, Matthew N.J. Seaman, David Neuhaus, Emily K. Herman

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

Funder: Discovery Grants from the Natural Sciences and Engineering Research Council of Canada (RES0043758, RES0046091)
VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35ae705b081e2551f54a714b8279d2c
http://link.springer.com/article/10.1038/s41467-020-18773-2

Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway

Autor: Michael D.J. Parkinson, Luther J. Davis, Andrew A. Peden, J. Paul Luzio, Lena Wartosch, Nicholas A. Bright, Judith Mantell, James R. Edgar

Publikováno v: Davis, L J, Bright, N A, Edgar, J R, Parkinson, M D J, Wartosch, L, Mantell, J M, Pedan, A A & Luzio, J P 2021, ' Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway ', Journal of Cell Science, vol. 134, no. 10, jcs255463 . https://doi.org/10.1242/jcs.255463
Journal of Cell Science
article-version (VoR) Version of Record

To provide insights into the kiss-and-run and full fusion events resulting in endocytic delivery to lysosomes, we investigated conditions causing increased tethering and pore formation between late endocytic organelles in HeLa cells. Knockout of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a83b6f9f1fc8c7e1f1f0a750cf1e98
https://hdl.handle.net/1983/42c57471-e32d-4a11-a5b1-16a7d167d1cc

The Lysosome and Intracellular Signalling

Autor: Geoffrey G, Hesketh, Lena, Wartosch, Luther J, Davis, Nicholas A, Bright, J Paul, Luzio

Publikováno v: Progress in molecular and subcellular biology. 57

In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d3a59c9b031eb3b514f99b1c0b55c271
https://pubmed.ncbi.nlm.nih.gov/30097775

The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C

Autor: Anita K, Ho, Jane L, Wagstaff, Paul T, Manna, Lena, Wartosch, Seema, Qamar, Elspeth F, Garman, Stefan M V, Freund, Rhys C, Roberts

Publikováno v: BMC Biology

Background Mutations in Lipopolysaccharide-induced tumour necrosis factor-α factor (LITAF) cause the autosomal dominant inherited peripheral neuropathy, Charcot-Marie-Tooth disease type 1C (CMT1C). LITAF encodes a 17 kDa protein containing an N-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::15e79749af59ee8fa339c4af51274bc0
https://doi.org/10.1186/s12915-016-0332-8